(21 nodes) Negative regulation of smoothened signaling pathway network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	mgrn1	Mahogunin, ring finger 1b. (548 aa)
	ptch2	Patched 2. (1299 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	gpc3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (541 aa)
	MOSMO	Modulator of smoothened. (167 aa)
	LOC105929235	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (334 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	kif7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1227 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	rb1	Retinoblastoma-associated protein. (913 aa)
	IFT122	Intraflagellar transport 122. (1079 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (449 aa)
	LOC105939479	GLIS family zinc finger 2. (496 aa)
	rest	RE1-silencing transcription factor. (906 aa)
	LOC105932051	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	gpr161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (528 aa)
	LOC105935432	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	glis2	GLIS family zinc finger 2b. (486 aa)
	ulk3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (469 aa)
	rfx4	Transcription factor RFX4. (737 aa)
	hhip	Hedgehog interacting protein. (739 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSFHEP00000009221	ptch2	ENSFHEP00000009221	ENSFHEP00000020070	Uncharacterized protein.	Patched 2.	0.964
ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	Growth arrest-specific 1b.	Uncharacterized protein.	0.905
ENSFHEP00000017921	ptch2	ENSFHEP00000017921	ENSFHEP00000020070	Growth arrest-specific 1b.	Patched 2.	0.936
IFT122	gpr161	ENSFHEP00000000622	ENSFHEP00000029512	Intraflagellar transport 122.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.746
IFT122	kif7	ENSFHEP00000000622	ENSFHEP00000004114	Intraflagellar transport 122.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.421
LOC105929235	LOC105935432	ENSFHEP00000009491	ENSFHEP00000029026	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.901
LOC105929235	gpr161	ENSFHEP00000009491	ENSFHEP00000029512	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.764
LOC105929235	kif7	ENSFHEP00000009491	ENSFHEP00000004114	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.606
LOC105929235	prkacb	ENSFHEP00000009491	ENSFHEP00000003191	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.902
LOC105932051	LOC105935432	ENSFHEP00000029760	ENSFHEP00000029026	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.901
LOC105932051	gpr161	ENSFHEP00000029760	ENSFHEP00000029512	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.764
LOC105932051	kif7	ENSFHEP00000029760	ENSFHEP00000004114	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.606
LOC105932051	prkacb	ENSFHEP00000029760	ENSFHEP00000003191	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.902
LOC105935432	LOC105929235	ENSFHEP00000029026	ENSFHEP00000009491	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	0.901
LOC105935432	LOC105932051	ENSFHEP00000029026	ENSFHEP00000029760	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.901
LOC105935432	gpr161	ENSFHEP00000029026	ENSFHEP00000029512	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	0.789
LOC105935432	kif7	ENSFHEP00000029026	ENSFHEP00000004114	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.606
LOC105935432	prkacb	ENSFHEP00000029026	ENSFHEP00000003191	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.953
gpr161	IFT122	ENSFHEP00000029512	ENSFHEP00000000622	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family.	Intraflagellar transport 122.	0.746