(49 nodes) Positive regulation of mitotic cell cycle network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	cdt1	Chromatin licensing and DNA replication factor 1. (630 aa)
	plrg1	Pleiotropic regulator 1. (445 aa)
	rgcc	Regulator of cell cycle. (127 aa)
	rb1	Retinoblastoma-associated protein. (913 aa)
	LOC105923405	CULLIN_2 domain-containing protein; Belongs to the cullin family. (528 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1250 aa)
	mtbp	Mdm2-binding protein. (878 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	anapc7	Anaphase promoting complex subunit 7. (580 aa)
	ENSFHEP00000005885	PHD-type domain-containing protein. (351 aa)
	LOC105937222	F-box only protein 5. (431 aa)
	ENSFHEP00000006280	Uncharacterized protein. (171 aa)
	CDC25B	M-phase inducer phosphatase 1. (572 aa)
	LOC105933792	Cullin 4A; Belongs to the cullin family. (653 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	anapc5	Anaphase promoting complex subunit 5. (765 aa)
	ENSFHEP00000009885	Uncharacterized protein. (303 aa)
	brca2	BRCA2 DNA repair associated. (2841 aa)
	CPSF3	CPSF73-100_C domain-containing protein. (369 aa)
	ENSFHEP00000010837	Lactamase_B domain-containing protein. (193 aa)
	AIF1	Allograft inflammatory factor 1. (151 aa)
	mblac1	Metallo-beta-lactamase domain containing 1. (216 aa)
	LOC105918680	ADAM metallopeptidase domain 17b. (476 aa)
	rad51c	RAD51 paralog C. (341 aa)
	ppp1r10	Protein phosphatase 1, regulatory subunit 10. (799 aa)
	ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	ENSFHEP00000017631	Cell division cycle associated 5. (248 aa)
	mad2l1bp	MAD2L1-binding protein. (379 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (116 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (343 aa)
	ENSFHEP00000021531	MBD domain-containing protein. (133 aa)
	stil	Uncharacterized protein. (845 aa)
	LOC105934010	Cyclin D2, b; Belongs to the cyclin family. (367 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	lgmn	Legumain. (436 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
	ENSFHEP00000024947	Uncharacterized protein. (688 aa)
	LOC105927641	ADAM metallopeptidase domain 17a. (865 aa)
	LOC105931481	Cyclin D2, a; Belongs to the cyclin family. (296 aa)
	ENSFHEP00000027531	Uncharacterized protein. (95 aa)
	ENSFHEP00000029520	Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (382 aa)
	LOC105918688	Cleavage and polyadenylation specific factor 3. (686 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (574 aa)
	ttl	Tubulin tyrosine ligase. (362 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (868 aa)
	LOC105919250	MBD domain-containing protein. (881 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	LOC105938762	Storkhead box 1. (1084 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25B	CUL3	ENSFHEP00000007184	ENSFHEP00000016369	M-phase inducer phosphatase 1.	Cullin 3; Belongs to the cullin family.	0.456
CDC25B	ENSFHEP00000027531	ENSFHEP00000007184	ENSFHEP00000027531	M-phase inducer phosphatase 1.	Uncharacterized protein.	0.516
CDC25B	LOC105923405	ENSFHEP00000007184	ENSFHEP00000002068	M-phase inducer phosphatase 1.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.456
CDC25B	LOC105931481	ENSFHEP00000007184	ENSFHEP00000026719	M-phase inducer phosphatase 1.	Cyclin D2, a; Belongs to the cyclin family.	0.818
CDC25B	LOC105934010	ENSFHEP00000007184	ENSFHEP00000022436	M-phase inducer phosphatase 1.	Cyclin D2, b; Belongs to the cyclin family.	0.818
CDC25B	ccnd1	ENSFHEP00000007184	ENSFHEP00000016337	M-phase inducer phosphatase 1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.818
CPSF3	ENSFHEP00000006280	ENSFHEP00000010799	ENSFHEP00000006280	CPSF73-100_C domain-containing protein.	Uncharacterized protein.	0.496
CPSF3	ENSFHEP00000010837	ENSFHEP00000010799	ENSFHEP00000010837	CPSF73-100_C domain-containing protein.	Lactamase_B domain-containing protein.	0.900
CPSF3	LOC105918688	ENSFHEP00000010799	ENSFHEP00000029802	CPSF73-100_C domain-containing protein.	Cleavage and polyadenylation specific factor 3.	0.900
CPSF3	LSM10	ENSFHEP00000010799	ENSFHEP00000021368	CPSF73-100_C domain-containing protein.	LSM10, U7 small nuclear RNA associated.	0.802
CPSF3	cdc23	ENSFHEP00000010799	ENSFHEP00000029805	CPSF73-100_C domain-containing protein.	CDC23 (cell division cycle 23, yeast, homolog).	0.419
CUL3	CDC25B	ENSFHEP00000016369	ENSFHEP00000007184	Cullin 3; Belongs to the cullin family.	M-phase inducer phosphatase 1.	0.456
CUL3	ENSFHEP00000027531	ENSFHEP00000016369	ENSFHEP00000027531	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.454
CUL3	ENSFHEP00000029520	ENSFHEP00000016369	ENSFHEP00000029520	Cullin 3; Belongs to the cullin family.	Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily.	0.443
CUL3	LOC105923405	ENSFHEP00000016369	ENSFHEP00000002068	Cullin 3; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.947
CUL3	LOC105931481	ENSFHEP00000016369	ENSFHEP00000026719	Cullin 3; Belongs to the cullin family.	Cyclin D2, a; Belongs to the cyclin family.	0.716
CUL3	LOC105933792	ENSFHEP00000016369	ENSFHEP00000008575	Cullin 3; Belongs to the cullin family.	Cullin 4A; Belongs to the cullin family.	0.645
CUL3	LOC105934010	ENSFHEP00000016369	ENSFHEP00000022436	Cullin 3; Belongs to the cullin family.	Cyclin D2, b; Belongs to the cyclin family.	0.716
CUL3	LOC105937222	ENSFHEP00000016369	ENSFHEP00000006033	Cullin 3; Belongs to the cullin family.	F-box only protein 5.	0.808
CUL3	ccnd1	ENSFHEP00000016369	ENSFHEP00000016337	Cullin 3; Belongs to the cullin family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.716