(48 nodes) Developmental pigmentation network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (637 aa)
	oca2	Oculocutaneous albinism II. (838 aa)
	ENSFHEP00000027723	RING-type domain-containing protein. (497 aa)
	bloc1s3	Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (196 aa)
	LOC105929187	Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	bloc1s5	Biogenesis of lysosomal organelles complex-1, subunit 5, muted. (153 aa)
	LOC105930247	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (395 aa)
	vps18	VPS18 core subunit of CORVET and HOPS complexes. (982 aa)
	LOC105916225	RAB38c, member of RAS oncogene family. (135 aa)
	ENSFHEP00000034099	Uncharacterized protein. (146 aa)
	LOC105933618	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	dct	Dopachrome tautomerase. (514 aa)
	slc24a5	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (481 aa)
	LOC105915554	Zgc:162171. (226 aa)
	tyrp1	Tyrosinase related protein 1. (524 aa)
	HPS6	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3. (797 aa)
	ap3d1	Adaptor related protein complex 3 subunit delta 1. (1256 aa)
	hps5	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1103 aa)
	rnf41	E3 ubiquitin-protein ligase NRDP1. (318 aa)
	ENSFHEP00000005625	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (278 aa)
	LOC105921308	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (410 aa)
	bcl2l11	Uncharacterized protein. (239 aa)
	ednra	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	ric8b	RIC8 guanine nucleotide exchange factor B. (527 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1040 aa)
	ENSFHEP00000007632	Ankyrin repeat domain 27 (VPS9 domain). (363 aa)
	LOC105939576	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (488 aa)
	mpv17	Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (177 aa)
	ENSFHEP00000009335	Uncharacterized protein. (190 aa)
	psenen	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	meox1	Homeobox protein MOX-1. (265 aa)
	LOC105925877	Tripartite motif containing 33. (1194 aa)
	lrmda	Leucine rich melanocyte differentiation associated. (233 aa)
	dio2	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. (266 aa)
	bcl2	BCL2 apoptosis regulator b. (230 aa)
	dicer1	Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily. (1793 aa)
	LOC105924805	Uncharacterized protein. (626 aa)
	tfap2e	Transcription factor AP-2 epsilon. (416 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (149 aa)
	LOC105917314	Uncharacterized protein. (435 aa)
	rab32	RAB32a, member RAS oncogene family. (213 aa)
	hps1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (676 aa)
	bloc1s6	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (170 aa)
	tyr	Tyrosinase. (571 aa)
	RAB38	RAB38, member RAS oncogene family. (212 aa)
	cd63	Tetraspanin. (240 aa)
	LOC105916672	Tyrosinase-related protein 1b. (533 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000005625	LOC105939576	ENSFHEP00000005625	ENSFHEP00000009181	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.907
ENSFHEP00000005625	psenen	ENSFHEP00000005625	ENSFHEP00000010681	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin enhancer, gamma-secretase subunit.	0.996
ENSFHEP00000007632	LOC105915554	ENSFHEP00000007632	ENSFHEP00000002097	Ankyrin repeat domain 27 (VPS9 domain).	Zgc:162171.	0.684
ENSFHEP00000007632	LOC105916225	ENSFHEP00000007632	ENSFHEP00000033646	Ankyrin repeat domain 27 (VPS9 domain).	RAB38c, member of RAS oncogene family.	0.684
ENSFHEP00000007632	RAB38	ENSFHEP00000007632	ENSFHEP00000022748	Ankyrin repeat domain 27 (VPS9 domain).	RAB38, member RAS oncogene family.	0.684
ENSFHEP00000007632	ap3d1	ENSFHEP00000007632	ENSFHEP00000003225	Ankyrin repeat domain 27 (VPS9 domain).	Adaptor related protein complex 3 subunit delta 1.	0.573
ENSFHEP00000007632	rab32	ENSFHEP00000007632	ENSFHEP00000021331	Ankyrin repeat domain 27 (VPS9 domain).	RAB32a, member RAS oncogene family.	0.684
ENSFHEP00000009335	bcl2l11	ENSFHEP00000009335	ENSFHEP00000006303	Uncharacterized protein.	Uncharacterized protein.	0.993
ENSFHEP00000034099	bloc1s3	ENSFHEP00000034099	ENSFHEP00000029172	Uncharacterized protein.	Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.	0.685
ENSFHEP00000034099	bloc1s6	ENSFHEP00000034099	ENSFHEP00000022433	Uncharacterized protein.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.787
ENSFHEP00000034099	hps5	ENSFHEP00000034099	ENSFHEP00000003807	Uncharacterized protein.	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.522
HPS6	LOC105917314	ENSFHEP00000002966	ENSFHEP00000020709	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Uncharacterized protein.	0.491
HPS6	LOC105924805	ENSFHEP00000002966	ENSFHEP00000017408	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Uncharacterized protein.	0.637
HPS6	RAB38	ENSFHEP00000002966	ENSFHEP00000022748	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	RAB38, member RAS oncogene family.	0.516
HPS6	ap3d1	ENSFHEP00000002966	ENSFHEP00000003225	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Adaptor related protein complex 3 subunit delta 1.	0.572
HPS6	bloc1s3	ENSFHEP00000002966	ENSFHEP00000029172	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.	0.636
HPS6	bloc1s6	ENSFHEP00000002966	ENSFHEP00000022433	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]	0.618
HPS6	dct	ENSFHEP00000002966	ENSFHEP00000034387	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Dopachrome tautomerase.	0.522
HPS6	hps1	ENSFHEP00000002966	ENSFHEP00000022224	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.	0.542
HPS6	hps5	ENSFHEP00000002966	ENSFHEP00000003807	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.	Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.	0.786