(29 nodes) Positive regulation of receptor-mediated endocytosis network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC105928170	SCY domain-containing protein. (110 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (153 aa)
	ENSFHEP00000032057	Uncharacterized protein. (959 aa)
	ENSFHEP00000032510	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (133 aa)
	ENSFHEP00000032605	Uncharacterized protein. (68 aa)
	ENSFHEP00000032624	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (194 aa)
	dab2	DAB adaptor protein 2. (769 aa)
	pick1	Protein interacting with prkca 1. (393 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (674 aa)
	ahi1	Abelson helper integration site 1. (1202 aa)
	ENSFHEP00000002273	PDZ domain-containing protein. (156 aa)
	scyl2	SCY1 like pseudokinase 2. (915 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (312 aa)
	LOC105935574	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	ENSFHEP00000007001	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (253 aa)
	LOC105920636	Uncharacterized protein. (362 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (381 aa)
	ENSFHEP00000011031	Clusterin; Belongs to the clusterin family. (412 aa)
	tbc1d5	TBC1 domain family, member 5. (870 aa)
	ENSFHEP00000013800	Gremlin 1a, DAN family BMP antagonist. (181 aa)
	clu	Clusterin; Belongs to the clusterin family. (460 aa)
	LOC105920339	Clusterin; Belongs to the clusterin family. (464 aa)
	ENSFHEP00000016902	Low density lipoprotein receptor adaptor protein 1a. (221 aa)
	LOC105936474	Vitronectin a. (544 aa)
	LOC105939281	Vitronectin b. (361 aa)
	fmr1	Fragile X mental retardation 1. (604 aa)
	cd63	Tetraspanin. (240 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	PDZ domain-containing protein.	Uncharacterized protein.	0.560
ENSFHEP00000002273	LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	PDZ domain-containing protein.	Uncharacterized protein.	0.586
ENSFHEP00000016902	dab2	ENSFHEP00000016902	ENSFHEP00000032952	Low density lipoprotein receptor adaptor protein 1a.	DAB adaptor protein 2.	0.949
ENSFHEP00000016902	ldlrap1	ENSFHEP00000016902	ENSFHEP00000005912	Low density lipoprotein receptor adaptor protein 1a.	Low density lipoprotein receptor adaptor protein 1b.	0.929
ENSFHEP00000016902	pcsk9	ENSFHEP00000016902	ENSFHEP00000000308	Low density lipoprotein receptor adaptor protein 1a.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.416
ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.560
LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.586
LOC105936474	LOC105939281	ENSFHEP00000018951	ENSFHEP00000019615	Vitronectin a.	Vitronectin b.	0.951
LOC105936474	serpine1	ENSFHEP00000018951	ENSFHEP00000034886	Vitronectin a.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.980
LOC105936474	vegfa	ENSFHEP00000018951	ENSFHEP00000026266	Vitronectin a.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.430
LOC105939281	LOC105936474	ENSFHEP00000019615	ENSFHEP00000018951	Vitronectin b.	Vitronectin a.	0.951
LOC105939281	serpine1	ENSFHEP00000019615	ENSFHEP00000034886	Vitronectin b.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.980
LOC105939281	vegfa	ENSFHEP00000019615	ENSFHEP00000026266	Vitronectin b.	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	0.430
dab2	ENSFHEP00000016902	ENSFHEP00000032952	ENSFHEP00000016902	DAB adaptor protein 2.	Low density lipoprotein receptor adaptor protein 1a.	0.949
dab2	ldlrap1	ENSFHEP00000032952	ENSFHEP00000005912	DAB adaptor protein 2.	Low density lipoprotein receptor adaptor protein 1b.	0.962
ldlrap1	ENSFHEP00000016902	ENSFHEP00000005912	ENSFHEP00000016902	Low density lipoprotein receptor adaptor protein 1b.	Low density lipoprotein receptor adaptor protein 1a.	0.929
ldlrap1	dab2	ENSFHEP00000005912	ENSFHEP00000032952	Low density lipoprotein receptor adaptor protein 1b.	DAB adaptor protein 2.	0.962
ldlrap1	pcsk9	ENSFHEP00000005912	ENSFHEP00000000308	Low density lipoprotein receptor adaptor protein 1b.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.525
pcsk9	ENSFHEP00000016902	ENSFHEP00000000308	ENSFHEP00000016902	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	Low density lipoprotein receptor adaptor protein 1a.	0.416
pcsk9	ldlrap1	ENSFHEP00000000308	ENSFHEP00000005912	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	Low density lipoprotein receptor adaptor protein 1b.	0.525