(20 nodes) Mesodermal cell differentiation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	itgb4	Integrin beta. (1916 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	hmga2	High mobility group protein HMGI-C. (115 aa)
	LOC105921518	Lysine (K)-specific demethylase 6A, like. (1475 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	ENSFHEP00000027539	Uncharacterized protein. (362 aa)
	LOC105917074	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (329 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)
	lclat1	Lysocardiolipin acyltransferase 1. (381 aa)
	LOC105929484	Mesogenin 1. (144 aa)
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1442 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	LOC105926723	Forkhead box H1. (500 aa)
	LOC105932189	Lysine (K)-specific demethylase 6B, b. (1731 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1059 aa)
	LOC105917077	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	LOC105920554	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1069 aa)
	LOC105940360	Lysine (K)-specific demethylase 6B, a. (2071 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105917074	LOC105923386	ENSFHEP00000027545	ENSFHEP00000002289	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2 like.	0.949
LOC105917074	sfrp2	ENSFHEP00000027545	ENSFHEP00000022060	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.936
LOC105917077	LOC105923386	ENSFHEP00000009794	ENSFHEP00000002289	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2 like.	0.968
LOC105917077	sfrp2	ENSFHEP00000009794	ENSFHEP00000022060	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein 2.	0.949
LOC105920554	itga3	ENSFHEP00000011151	ENSFHEP00000005535	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	0.948
LOC105920554	itgb4	ENSFHEP00000011151	ENSFHEP00000016010	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta.	0.929
LOC105921518	LOC105932189	ENSFHEP00000018141	ENSFHEP00000004378	Lysine (K)-specific demethylase 6A, like.	Lysine (K)-specific demethylase 6B, b.	0.723
LOC105921518	LOC105940360	ENSFHEP00000018141	ENSFHEP00000015446	Lysine (K)-specific demethylase 6A, like.	Lysine (K)-specific demethylase 6B, a.	0.708
LOC105921518	kdm6a	ENSFHEP00000018141	ENSFHEP00000001558	Lysine (K)-specific demethylase 6A, like.	Lysine (K)-specific demethylase 6A.	0.713
LOC105923386	LOC105917074	ENSFHEP00000002289	ENSFHEP00000027545	Secreted frizzled-related protein 2 like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.949
LOC105923386	LOC105917077	ENSFHEP00000002289	ENSFHEP00000009794	Secreted frizzled-related protein 2 like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.968
LOC105932189	LOC105921518	ENSFHEP00000004378	ENSFHEP00000018141	Lysine (K)-specific demethylase 6B, b.	Lysine (K)-specific demethylase 6A, like.	0.723
LOC105932189	LOC105940360	ENSFHEP00000004378	ENSFHEP00000015446	Lysine (K)-specific demethylase 6B, b.	Lysine (K)-specific demethylase 6B, a.	0.716
LOC105932189	kdm6a	ENSFHEP00000004378	ENSFHEP00000001558	Lysine (K)-specific demethylase 6B, b.	Lysine (K)-specific demethylase 6A.	0.720
LOC105940360	LOC105921518	ENSFHEP00000015446	ENSFHEP00000018141	Lysine (K)-specific demethylase 6B, a.	Lysine (K)-specific demethylase 6A, like.	0.708
LOC105940360	LOC105932189	ENSFHEP00000015446	ENSFHEP00000004378	Lysine (K)-specific demethylase 6B, a.	Lysine (K)-specific demethylase 6B, b.	0.716
LOC105940360	kdm6a	ENSFHEP00000015446	ENSFHEP00000001558	Lysine (K)-specific demethylase 6B, a.	Lysine (K)-specific demethylase 6A.	0.708
itga3	LOC105920554	ENSFHEP00000005535	ENSFHEP00000011151	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.948
itga3	itgb4	ENSFHEP00000005535	ENSFHEP00000016010	Integrin, alpha 3b; Belongs to the integrin alpha chain family.	Integrin beta.	0.929
itgb4	LOC105920554	ENSFHEP00000016010	ENSFHEP00000011151	Integrin beta.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.929