(44 nodes) Neuron fate commitment network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	ENSFHEP00000034755	MH1 domain-containing protein. (154 aa)
	LOC105921341	MH2 domain-containing protein. (222 aa)
	lhx4	LIM homeobox 4. (389 aa)
	hoxc4	Homeobox C10a. (481 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
	LOC105932327	ISL LIM homeobox 2a. (359 aa)
	lhx9	LIM homeobox 9. (399 aa)
	ENSFHEP00000002908	TPR_REGION domain-containing protein. (142 aa)
	foxg1	Forkhead box G1a. (343 aa)
	LOC105936233	Homeobox domain-containing protein. (315 aa)
	LOC105925932	Hairy and enhancer of split-related protein HELT. (258 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1040 aa)
	LOC105916909	Atonal bHLH transcription factor 1b. (190 aa)
	LOC105920529	Mothers against decapentaplegic homolog. (520 aa)
	foxn4	Forkhead box N4. (517 aa)
	gsx1	GS homeobox 1. (243 aa)
	olig2	Oligodendrocyte lineage transcription factor 2. (272 aa)
	LOC105915881	Fork-head domain-containing protein. (390 aa)
	LOC105915854	Uncharacterized protein. (336 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	ENSFHEP00000016045	Atonal bHLH transcription factor 1c. (197 aa)
	gsx2	GS homeobox 2. (239 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	olig3	Oligodendrocyte transcription factor 3. (239 aa)
	axin1	Axin 1. (851 aa)
	lhx2	LIM/homeobox protein Lhx2. (417 aa)
	LOC105919700	Peptidylprolyl isomerase. (407 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	LOC105917284	Homeobox domain-containing protein. (273 aa)
	zc4h2	Zinc finger, C4H2 domain containing. (224 aa)
	gdf5	Growth differentiation factor 5. (487 aa)
	LHX3	LIM homeobox 3. (400 aa)
	LOC105924100	Uncharacterized protein. (585 aa)
	ENSFHEP00000024850	Fork-head domain-containing protein. (298 aa)
	gdf6	Growth differentiation factor 6a. (414 aa)
	ENSFHEP00000028195	Gastrulation brain homeobox 1. (200 aa)
	ISL2	ISL LIM homeobox 2b. (360 aa)
	LOC105919375	ISL LIM homeobox 1. (298 aa)
	atoh1	Atonal bHLH transcription factor 1a. (352 aa)
	ENSFHEP00000030100	Oligodendrocyte transcription factor 1. (276 aa)
	mnx1	Motor neuron and pancreas homeobox protein 1. (320 aa)
	thrb	Thyroid hormone receptor beta. (395 aa)
	LOC105930774	Mothers against decapentaplegic homolog. (393 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000000835	dlx3	ENSFHEP00000000835	ENSFHEP00000017641	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.424
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000000835	shh	ENSFHEP00000000835	ENSFHEP00000014527	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.617
ENSFHEP00000024850	ENSFHEP00000034755	ENSFHEP00000024850	ENSFHEP00000034755	Fork-head domain-containing protein.	MH1 domain-containing protein.	0.597
ENSFHEP00000024850	LOC105915881	ENSFHEP00000024850	ENSFHEP00000014069	Fork-head domain-containing protein.	Fork-head domain-containing protein.	0.904
ENSFHEP00000024850	LOC105920529	ENSFHEP00000024850	ENSFHEP00000011523	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.597
ENSFHEP00000024850	LOC105921341	ENSFHEP00000024850	ENSFHEP00000034764	Fork-head domain-containing protein.	MH2 domain-containing protein.	0.597
ENSFHEP00000024850	LOC105930774	ENSFHEP00000024850	ENSFHEP00000032911	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.597
ENSFHEP00000024850	fgf3	ENSFHEP00000024850	ENSFHEP00000033502	Fork-head domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.523
ENSFHEP00000024850	foxg1	ENSFHEP00000024850	ENSFHEP00000004315	Fork-head domain-containing protein.	Forkhead box G1a.	0.902
ENSFHEP00000030100	atoh1	ENSFHEP00000030100	ENSFHEP00000028572	Oligodendrocyte transcription factor 1.	Atonal bHLH transcription factor 1a.	0.453
ENSFHEP00000034755	ENSFHEP00000024850	ENSFHEP00000034755	ENSFHEP00000024850	MH1 domain-containing protein.	Fork-head domain-containing protein.	0.597
ENSFHEP00000034755	LOC105915881	ENSFHEP00000034755	ENSFHEP00000014069	MH1 domain-containing protein.	Fork-head domain-containing protein.	0.597
ENSFHEP00000034755	LOC105920529	ENSFHEP00000034755	ENSFHEP00000011523	MH1 domain-containing protein.	Mothers against decapentaplegic homolog.	0.715
ENSFHEP00000034755	LOC105921341	ENSFHEP00000034755	ENSFHEP00000034764	MH1 domain-containing protein.	MH2 domain-containing protein.	0.927
ENSFHEP00000034755	foxg1	ENSFHEP00000034755	ENSFHEP00000004315	MH1 domain-containing protein.	Forkhead box G1a.	0.597
ISL2	LHX3	ENSFHEP00000028248	ENSFHEP00000023037	ISL LIM homeobox 2b.	LIM homeobox 3.	0.863
ISL2	lhx4	ENSFHEP00000028248	ENSFHEP00000023878	ISL LIM homeobox 2b.	LIM homeobox 4.	0.855
ISL2	mnx1	ENSFHEP00000028248	ENSFHEP00000030589	ISL LIM homeobox 2b.	Motor neuron and pancreas homeobox protein 1.	0.414
LHX3	ISL2	ENSFHEP00000023037	ENSFHEP00000028248	LIM homeobox 3.	ISL LIM homeobox 2b.	0.863