(27 nodes) Embryonic viscerocranium morphogenesis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000001865	Stealth_CR4 domain-containing protein. (141 aa)
	dlx2	Distal-less homeobox 2b. (278 aa)
	rad21	RAD21 cohesin complex component a. (639 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	gnptab	Uncharacterized protein. (340 aa)
	fst	Follistatin a. (349 aa)
	tbx1	T-box transcription factor TBX1. (498 aa)
	LOC105929184	RNA polymerase I and III subunit D. (115 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	ENSFHEP00000014677	Uncharacterized protein. (104 aa)
	LOC105933177	Uncharacterized protein. (254 aa)
	LOC105930806	Nipped-B protein. (2737 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	mmachc	Metabolism of cobalamin associated C. (263 aa)
	alcam	Activated leukocyte cell adhesion molecule b. (563 aa)
	pitx2	Homeobox protein. (312 aa)
	nbas	Neuroblastoma amplified sequence. (2131 aa)
	LOC105931684	RAD21 cohesin complex component b. (592 aa)
	LOC105919044	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
	dlx1	Distal-less homeobox 1a. (254 aa)
	LOC105939942	Nipped-B protein. (2440 aa)
	LOC105916516	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	LOC105935872	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC105935255	RAD21 cohesin complex component like 1. (544 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000001865	gnptab	ENSFHEP00000001865	ENSFHEP00000004869	Stealth_CR4 domain-containing protein.	Uncharacterized protein.	0.933
ENSFHEP00000003392	dlx2	ENSFHEP00000003392	ENSFHEP00000003050	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 2b.	0.506
ENSFHEP00000003392	dlx5	ENSFHEP00000003392	ENSFHEP00000014533	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 5a.	0.424
ENSFHEP00000003392	shh	ENSFHEP00000003392	ENSFHEP00000014527	Heart and neural crest derivatives expressed 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.464
ENSFHEP00000014677	LOC105931684	ENSFHEP00000014677	ENSFHEP00000025985	Uncharacterized protein.	RAD21 cohesin complex component b.	0.888
ENSFHEP00000014677	LOC105935255	ENSFHEP00000014677	ENSFHEP00000034985	Uncharacterized protein.	RAD21 cohesin complex component like 1.	0.888
ENSFHEP00000014677	LOC105939942	ENSFHEP00000014677	ENSFHEP00000030843	Uncharacterized protein.	Nipped-B protein.	0.900
ENSFHEP00000014677	rad21	ENSFHEP00000014677	ENSFHEP00000003337	Uncharacterized protein.	RAD21 cohesin complex component a.	0.888
LOC105916516	LOC105935872	ENSFHEP00000032621	ENSFHEP00000033555	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.953
LOC105916516	shh	ENSFHEP00000032621	ENSFHEP00000014527	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.555
LOC105916516	wnt4	ENSFHEP00000032621	ENSFHEP00000017971	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.714
LOC105930806	LOC105931684	ENSFHEP00000017356	ENSFHEP00000025985	Nipped-B protein.	RAD21 cohesin complex component b.	0.888
LOC105930806	LOC105935255	ENSFHEP00000017356	ENSFHEP00000034985	Nipped-B protein.	RAD21 cohesin complex component like 1.	0.888
LOC105930806	rad21	ENSFHEP00000017356	ENSFHEP00000003337	Nipped-B protein.	RAD21 cohesin complex component a.	0.888
LOC105931684	ENSFHEP00000014677	ENSFHEP00000025985	ENSFHEP00000014677	RAD21 cohesin complex component b.	Uncharacterized protein.	0.888
LOC105931684	LOC105930806	ENSFHEP00000025985	ENSFHEP00000017356	RAD21 cohesin complex component b.	Nipped-B protein.	0.888
LOC105931684	LOC105935255	ENSFHEP00000025985	ENSFHEP00000034985	RAD21 cohesin complex component b.	RAD21 cohesin complex component like 1.	0.970
LOC105931684	LOC105939942	ENSFHEP00000025985	ENSFHEP00000030843	RAD21 cohesin complex component b.	Nipped-B protein.	0.888
LOC105931684	rad21	ENSFHEP00000025985	ENSFHEP00000003337	RAD21 cohesin complex component b.	RAD21 cohesin complex component a.	0.965
LOC105935255	ENSFHEP00000014677	ENSFHEP00000034985	ENSFHEP00000014677	RAD21 cohesin complex component like 1.	Uncharacterized protein.	0.888