(127 nodes) Skeletal system morphogenesis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105940353	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (352 aa)
	hoxc9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
	hoxc4	Homeobox C10a. (481 aa)
	hoxc4-2	Homeobox C4a. (268 aa)
	LOC105928913	FAM20B glycosaminoglycan xylosylkinase. (409 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
	LOC105939829	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSFHEP00000001865	Stealth_CR4 domain-containing protein. (141 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC105915540	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (732 aa)
	sox5	SRY-box transcription factor 5. (759 aa)
	dlx2	Distal-less homeobox 2b. (278 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	rad21	RAD21 cohesin complex component a. (639 aa)
	LOC105926683	RanBP-type and C3HC4-type zinc finger-containing protein 1. (733 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
	tcf15	Transcription factor 15. (179 aa)
	gnptab	Uncharacterized protein. (340 aa)
	fst	Follistatin a. (349 aa)
	sp5	Uncharacterized protein. (375 aa)
	tbx1	T-box transcription factor TBX1. (498 aa)
	rab33b	RAB33B, member RAS oncogene family a. (240 aa)
	mef2d	Myocyte enhancer factor 2d. (583 aa)
	RING1	Ring finger protein 1. (388 aa)
	anxa6	Annexin. (672 aa)
	mab21l1	Mab-21 3-like protein. (359 aa)
	ryk	Receptor like tyrosine kinase. (653 aa)
	gata3	Trans-acting T-cell-specific transcription factor GATA-3. (441 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (883 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	pkd1	Polycystic kidney disease 1a. (4308 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	LOC105935786	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (809 aa)
	kat2a	K(lysine) acetyltransferase 2A. (729 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	ENSFHEP00000011770	Si:ch211-246m6.4. (188 aa)
	ENSFHEP00000011863	Transmembrane protein 119b. (281 aa)
	LOC105930366	RNA binding motif protein 24a. (234 aa)
	LOC105918704	Ras-related protein Rap-1A. (184 aa)
	kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (792 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	sgpl1	Sphingosine-1-phosphate lyase 1. (565 aa)
	LOC105929184	RNA polymerase I and III subunit D. (115 aa)
	wdr60	WD repeat domain 60. (1055 aa)
	ENSFHEP00000014088	RNA binding motif protein 24b. (215 aa)
	edar	Ectodysplasin A receptor. (521 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	ENSFHEP00000014677	Uncharacterized protein. (104 aa)
	LOC105933177	Uncharacterized protein. (254 aa)
	ENSFHEP00000015248	Uncharacterized protein. (235 aa)
	LOC105935972	Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC105930806	Nipped-B protein. (2737 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (740 aa)
	rflnb	Refilin B. (204 aa)
	alx1	ALX homeobox 1. (315 aa)
	LOC105931924	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	MDFI	MyoD family inhibitor. (169 aa)
	ENSFHEP00000019886	Uncharacterized protein. (184 aa)
	LOC105922161	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (422 aa)
	LOC105933101	Fras1 related extracellular matrix 1b. (1295 aa)
	rab23	RAB23, member RAS oncogene family. (235 aa)
	mmachc	Metabolism of cobalamin associated C. (263 aa)
	LOC105940347	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (434 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1446 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (721 aa)
	frem1	Fras1 related extracellular matrix 1a. (2167 aa)
	zfand5	Zinc finger, AN1-type domain 5a. (205 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (433 aa)
	trip11	Thyroid hormone receptor interactor 11. (1975 aa)
	foxn3	Checkpoint suppressor 1. (482 aa)
	ENSFHEP00000023812	Uncharacterized protein. (139 aa)
	LOC105935262	RAP1A, member of RAS oncogene family a. (185 aa)
	alcam	Activated leukocyte cell adhesion molecule b. (563 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (499 aa)
	hoxd3	Homeobox D3a. (416 aa)
	hhip	Hedgehog interacting protein. (739 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1050 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (637 aa)
	pitx2	Homeobox protein. (312 aa)
	nbas	Neuroblastoma amplified sequence. (2131 aa)
	mab21l2	Mab-21 3-like protein. (359 aa)
	LOC105931684	RAD21 cohesin complex component b. (592 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	rnf2	Ring finger protein 2. (314 aa)
	glg1	Golgi glycoprotein 1b. (994 aa)
	ENSFHEP00000026670	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (127 aa)
	LOC105935060	MADS-box domain-containing protein. (497 aa)
	lrp6	Low density lipoprotein receptor-related protein 6. (784 aa)
	ENSFHEP00000027841	Uncharacterized protein. (221 aa)
	pex7	Peroxisomal biogenesis factor 7. (324 aa)
	ENSFHEP00000028182	Bromo domain-containing protein. (84 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	LOC105919044	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
	LOC105938432	Cysteine-serine-rich nuclear protein 1b. (570 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1600 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (927 aa)
	dlx1	Distal-less homeobox 1a. (254 aa)
	LOC105923080	Uncharacterized protein. (321 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	scx	Scleraxis bHLH transcription factor a. (215 aa)
	LOC105939942	Nipped-B protein. (2440 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2581 aa)
	LOC105935996	Uncharacterized protein. (185 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (579 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
	LOC105919252	Zgc:113363. (207 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	LOC105930240	Cysteine-serine-rich nuclear protein 1a. (576 aa)
	ankrd11	Ankyrin repeat domain 11. (2834 aa)
	LOC105916516	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	disp1	Dispatched homolog 1 (Drosophila). (671 aa)
	ENSFHEP00000033024	Uncharacterized protein. (61 aa)
	LOC105926254	HMG box domain-containing protein. (779 aa)
	LOC105916278	SRY-box transcription factor 6. (775 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	LOC105935872	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (706 aa)
	p2rx7	Purinergic receptor P2X, ligand-gated ion channel, 7. (615 aa)
	LOC105935255	RAD21 cohesin complex component like 1. (544 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	gja1	ENSFHEP00000030344	ENSFHEP00000011745	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.698
ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.491
ENSFHEP00000000835	ENSFHEP00000019886	ENSFHEP00000000835	ENSFHEP00000019886	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.602
ENSFHEP00000000835	ENSFHEP00000026670	ENSFHEP00000000835	ENSFHEP00000026670	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.602
ENSFHEP00000000835	ENSFHEP00000033024	ENSFHEP00000000835	ENSFHEP00000033024	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.602
ENSFHEP00000000835	LOC105931924	ENSFHEP00000000835	ENSFHEP00000018900	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.587
ENSFHEP00000000835	LOC105939829	ENSFHEP00000000835	ENSFHEP00000001369	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.588
ENSFHEP00000000835	dlx2	ENSFHEP00000000835	ENSFHEP00000003050	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 2b.	0.430
ENSFHEP00000000835	dlx3	ENSFHEP00000000835	ENSFHEP00000017641	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.424
ENSFHEP00000000835	dlx5	ENSFHEP00000000835	ENSFHEP00000014533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 5a.	0.420
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000000835	fgf4	ENSFHEP00000000835	ENSFHEP00000033511	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.625
ENSFHEP00000000835	fst	ENSFHEP00000000835	ENSFHEP00000004871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin a.	0.448
ENSFHEP00000000835	msx1	ENSFHEP00000000835	ENSFHEP00000003058	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Muscle segment homeobox 1a.	0.513
ENSFHEP00000000835	pdgfrb	ENSFHEP00000000835	ENSFHEP00000012823	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.949
ENSFHEP00000000835	pitx2	ENSFHEP00000000835	ENSFHEP00000025683	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein.	0.410
ENSFHEP00000000835	shh	ENSFHEP00000000835	ENSFHEP00000014527	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.617
ENSFHEP00000001865	gnptab	ENSFHEP00000001865	ENSFHEP00000004869	Stealth_CR4 domain-containing protein.	Uncharacterized protein.	0.933
ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
ENSFHEP00000003392	ENSFHEP00000023812	ENSFHEP00000003392	ENSFHEP00000023812	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.401