(78 nodes) Embryonic skeletal system development network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (721 aa)
	LOC105917264	Uncharacterized protein. (859 aa)
	ift140	Intraflagellar transport 140 homolog (Chlamydomonas). (1446 aa)
	mmachc	Metabolism of cobalamin associated C. (263 aa)
	dmrt2	Doublesex and mab-3 related transcription factor 2a. (593 aa)
	MDFI	MyoD family inhibitor. (169 aa)
	mks1	MKS transition zone complex subunit 1. (506 aa)
	ENSFHEP00000019104	Uncharacterized protein. (105 aa)
	alx1	ALX homeobox 1. (315 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	ENSFHEP00000017921	Growth arrest-specific 1b. (243 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	LOC105930806	Nipped-B protein. (2737 aa)
	LOC105935972	Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	LOC105933177	Uncharacterized protein. (254 aa)
	ENSFHEP00000014677	Uncharacterized protein. (104 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	ENSFHEP00000014088	RNA binding motif protein 24b. (215 aa)
	wdr60	WD repeat domain 60. (1055 aa)
	LOC105929184	RNA polymerase I and III subunit D. (115 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	LOC105930366	RNA binding motif protein 24a. (234 aa)
	gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (387 aa)
	ENSFHEP00000010347	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
	ENSFHEP00000009221	Uncharacterized protein. (268 aa)
	gata3	Trans-acting T-cell-specific transcription factor GATA-3. (441 aa)
	mab21l1	Mab-21 3-like protein. (359 aa)
	ednra	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	RING1	Ring finger protein 1. (388 aa)
	LOC105938506	Upper zone of growth plate and cartilage matrix associated b. (138 aa)
	LOC105921308	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (410 aa)
	tbx1	T-box transcription factor TBX1. (498 aa)
	LOC105937522	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	fst	Follistatin a. (349 aa)
	gnptab	Uncharacterized protein. (340 aa)
	sec23a	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (764 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	LOC105926683	RanBP-type and C3HC4-type zinc finger-containing protein 1. (733 aa)
	rad21	RAD21 cohesin complex component a. (639 aa)
	dlx2	Distal-less homeobox 2b. (278 aa)
	ENSFHEP00000001865	Stealth_CR4 domain-containing protein. (141 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
	LOC105928913	FAM20B glycosaminoglycan xylosylkinase. (409 aa)
	hoxc4-2	Homeobox C4a. (268 aa)
	hoxc4	Homeobox C10a. (481 aa)
	hoxc9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (262 aa)
	gdf5	Growth differentiation factor 5. (487 aa)
	ENSFHEP00000023812	Uncharacterized protein. (139 aa)
	SP3	Sp3a transcription factor. (699 aa)
	alcam	Activated leukocyte cell adhesion molecule b. (563 aa)
	hoxd3	Homeobox D3a. (416 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (637 aa)
	pitx2	Homeobox protein. (312 aa)
	nbas	Neuroblastoma amplified sequence. (2131 aa)
	mab21l2	Mab-21 3-like protein. (359 aa)
	LOC105931684	RAD21 cohesin complex component b. (592 aa)
	wdr19	WD repeat domain 19. (1343 aa)
	LOC105939045	Sp3b transcription factor. (648 aa)
	gdf6	Growth differentiation factor 6a. (414 aa)
	rnf2	Ring finger protein 2. (314 aa)
	deaf1	DEAF1 transcription factor. (558 aa)
	LOC105919044	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
	dlx1	Distal-less homeobox 1a. (254 aa)
	LOC105939942	Nipped-B protein. (2440 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2581 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (579 aa)
	sulf1	Sulfatase 1. (1146 aa)
	LOC105919252	Zgc:113363. (207 aa)
	ucma	Upper zone of growth plate and cartilage matrix associated a. (133 aa)
	LOC105922455	Extracellular sulfatase. (921 aa)
	LOC105916516	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
	disp1	Dispatched homolog 1 (Drosophila). (671 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	LOC105935872	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC105935255	RAD21 cohesin complex component like 1. (544 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.491
ENSFHEP00000000835	dlx2	ENSFHEP00000000835	ENSFHEP00000003050	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 2b.	0.430
ENSFHEP00000000835	dlx3	ENSFHEP00000000835	ENSFHEP00000017641	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.424
ENSFHEP00000000835	dlx5	ENSFHEP00000000835	ENSFHEP00000014533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 5a.	0.420
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000000835	fst	ENSFHEP00000000835	ENSFHEP00000004871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin a.	0.448
ENSFHEP00000000835	pdgfrb	ENSFHEP00000000835	ENSFHEP00000012823	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.949
ENSFHEP00000000835	pitx2	ENSFHEP00000000835	ENSFHEP00000025683	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein.	0.410
ENSFHEP00000000835	shh	ENSFHEP00000000835	ENSFHEP00000014527	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.617
ENSFHEP00000001865	gnptab	ENSFHEP00000001865	ENSFHEP00000004869	Stealth_CR4 domain-containing protein.	Uncharacterized protein.	0.933
ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
ENSFHEP00000003392	ENSFHEP00000023812	ENSFHEP00000003392	ENSFHEP00000023812	Heart and neural crest derivatives expressed 2.	Uncharacterized protein.	0.401
ENSFHEP00000003392	disp1	ENSFHEP00000003392	ENSFHEP00000032766	Heart and neural crest derivatives expressed 2.	Dispatched homolog 1 (Drosophila).	0.512
ENSFHEP00000003392	dlx2	ENSFHEP00000003392	ENSFHEP00000003050	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 2b.	0.506
ENSFHEP00000003392	dlx5	ENSFHEP00000003392	ENSFHEP00000014533	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 5a.	0.424
ENSFHEP00000003392	gata3	ENSFHEP00000003392	ENSFHEP00000007630	Heart and neural crest derivatives expressed 2.	Trans-acting T-cell-specific transcription factor GATA-3.	0.452
ENSFHEP00000003392	shh	ENSFHEP00000003392	ENSFHEP00000014527	Heart and neural crest derivatives expressed 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.464
ENSFHEP00000009221	ENSFHEP00000017921	ENSFHEP00000009221	ENSFHEP00000017921	Uncharacterized protein.	Growth arrest-specific 1b.	0.905
ENSFHEP00000009221	shh	ENSFHEP00000009221	ENSFHEP00000014527	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.949
ENSFHEP00000010347	LOC105916516	ENSFHEP00000010347	ENSFHEP00000032621	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.610