(22 nodes) Erythrocyte development network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105922122	Phospholipase A(2). (153 aa)
	sh2b3	SH2B adaptor protein 3. (717 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)
	LOC105933755	5-aminolevulinate synthase. (554 aa)
	epo	Erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (204 aa)
	LOC105920540	Uncharacterized protein. (271 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (565 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (156 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	ercc2	TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1100 aa)
	LOC105926861	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	srf	Serum response factor b. (599 aa)
	ENSFHEP00000009411	Uncharacterized protein. (139 aa)
	melk	Non-specific serine/threonine protein kinase. (680 aa)
	maea	Macrophage erythroblast attacher. (396 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (245 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	lyar	Ly1 antibody reactive. (333 aa)
	ENSFHEP00000001827	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1447 aa)
	LOC105919611	GATA binding protein 1a. (424 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009411	lyar	ENSFHEP00000009411	ENSFHEP00000003419	Uncharacterized protein.	Ly1 antibody reactive.	0.826
ENSFHEP00000009411	med1	ENSFHEP00000009411	ENSFHEP00000014059	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.976
ENSFHEP00000022320	LOC105919611	ENSFHEP00000022320	ENSFHEP00000001731	BHLH domain-containing protein.	GATA binding protein 1a.	0.844
ENSFHEP00000022320	LOC105920540	ENSFHEP00000022320	ENSFHEP00000028444	BHLH domain-containing protein.	Uncharacterized protein.	0.844
ENSFHEP00000022320	lmo2	ENSFHEP00000022320	ENSFHEP00000026291	BHLH domain-containing protein.	LIM domain only 2 (rhombotin-like 1).	0.984
LOC105919611	ENSFHEP00000022320	ENSFHEP00000001731	ENSFHEP00000022320	GATA binding protein 1a.	BHLH domain-containing protein.	0.844
LOC105919611	LOC105924010	ENSFHEP00000001731	ENSFHEP00000004618	GATA binding protein 1a.	Uncharacterized protein.	0.669
LOC105919611	LOC105933755	ENSFHEP00000001731	ENSFHEP00000030596	GATA binding protein 1a.	5-aminolevulinate synthase.	0.664
LOC105919611	LOC105935913	ENSFHEP00000001731	ENSFHEP00000032272	GATA binding protein 1a.	T-cell acute lymphocytic leukemia protein 1.	0.844
LOC105919611	bdh2	ENSFHEP00000001731	ENSFHEP00000006640	GATA binding protein 1a.	3-hydroxybutyrate dehydrogenase, type 2.	0.436
LOC105919611	lmo2	ENSFHEP00000001731	ENSFHEP00000026291	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.964
LOC105919611	med1	ENSFHEP00000001731	ENSFHEP00000014059	GATA binding protein 1a.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.418
LOC105919611	srf	ENSFHEP00000001731	ENSFHEP00000013718	GATA binding protein 1a.	Serum response factor b.	0.669
LOC105920540	ENSFHEP00000022320	ENSFHEP00000028444	ENSFHEP00000022320	Uncharacterized protein.	BHLH domain-containing protein.	0.844
LOC105920540	LOC105924010	ENSFHEP00000028444	ENSFHEP00000004618	Uncharacterized protein.	Uncharacterized protein.	0.669
LOC105920540	LOC105933755	ENSFHEP00000028444	ENSFHEP00000030596	Uncharacterized protein.	5-aminolevulinate synthase.	0.433
LOC105920540	LOC105935913	ENSFHEP00000028444	ENSFHEP00000032272	Uncharacterized protein.	T-cell acute lymphocytic leukemia protein 1.	0.844
LOC105920540	bdh2	ENSFHEP00000028444	ENSFHEP00000006640	Uncharacterized protein.	3-hydroxybutyrate dehydrogenase, type 2.	0.436
LOC105920540	lmo2	ENSFHEP00000028444	ENSFHEP00000026291	Uncharacterized protein.	LIM domain only 2 (rhombotin-like 1).	0.964
LOC105920540	med1	ENSFHEP00000028444	ENSFHEP00000014059	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.418