(24 nodes) Barbed-end actin filament capping network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	add3	Adducin 3 (gamma) a. (684 aa)
	capg	Capping protein (actin filament), gelsolin-like b. (363 aa)
	twf1	Twinfilin actin-binding protein 1a. (350 aa)
	LOC105927285	Adducin 3 (gamma) b. (620 aa)
	capza1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	twf2	Twinfilin actin-binding protein 2a. (446 aa)
	LOC105939416	Supervillin d. (1490 aa)
	gsn	Gelsolin a. (740 aa)
	LOC105920460	Scinderin like b. (720 aa)
	ENSFHEP00000012057	HP domain-containing protein. (87 aa)
	ENSFHEP00000012048	Uncharacterized protein. (253 aa)
	vill	Villin-like. (843 aa)
	LOC105916477	Supervillin c. (1551 aa)
	ENSFHEP00000006982	Gelsolin-like domain-containing protein. (102 aa)
	LOC105939099	Advillin. (818 aa)
	flii	FLII actin remodeling protein. (1273 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (274 aa)
	add1	Adducin 1 (alpha). (822 aa)
	add2	Adducin 2 (beta). (643 aa)
	LOC105927192	Twinfilin actin-binding protein 2b. (372 aa)
	svil	Supervillin a. (1875 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (316 aa)
	LOC105940068	Scinderin like a. (718 aa)
	ENSFHEP00000027806	HP domain-containing protein. (84 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPZA2	LOC105927192	ENSFHEP00000026870	ENSFHEP00000023379	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 2b.	0.663
CAPZA2	capza1	ENSFHEP00000026870	ENSFHEP00000018011	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.968
CAPZA2	capzb	ENSFHEP00000026870	ENSFHEP00000004080	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.995
CAPZA2	twf1	ENSFHEP00000026870	ENSFHEP00000020994	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 1a.	0.663
CAPZA2	twf2	ENSFHEP00000026870	ENSFHEP00000017265	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 2a.	0.663
ENSFHEP00000006982	LOC105920460	ENSFHEP00000006982	ENSFHEP00000012985	Gelsolin-like domain-containing protein.	Scinderin like b.	0.902
ENSFHEP00000006982	LOC105927192	ENSFHEP00000006982	ENSFHEP00000023379	Gelsolin-like domain-containing protein.	Twinfilin actin-binding protein 2b.	0.478
ENSFHEP00000006982	LOC105940068	ENSFHEP00000006982	ENSFHEP00000027682	Gelsolin-like domain-containing protein.	Scinderin like a.	0.902
ENSFHEP00000006982	gsn	ENSFHEP00000006982	ENSFHEP00000013416	Gelsolin-like domain-containing protein.	Gelsolin a.	0.907
ENSFHEP00000006982	twf1	ENSFHEP00000006982	ENSFHEP00000020994	Gelsolin-like domain-containing protein.	Twinfilin actin-binding protein 1a.	0.478
ENSFHEP00000006982	twf2	ENSFHEP00000006982	ENSFHEP00000017265	Gelsolin-like domain-containing protein.	Twinfilin actin-binding protein 2a.	0.478
ENSFHEP00000012048	LOC105939416	ENSFHEP00000012048	ENSFHEP00000015713	Uncharacterized protein.	Supervillin d.	0.474
LOC105920460	ENSFHEP00000006982	ENSFHEP00000012985	ENSFHEP00000006982	Scinderin like b.	Gelsolin-like domain-containing protein.	0.902
LOC105920460	LOC105927192	ENSFHEP00000012985	ENSFHEP00000023379	Scinderin like b.	Twinfilin actin-binding protein 2b.	0.435
LOC105920460	LOC105939099	ENSFHEP00000012985	ENSFHEP00000006715	Scinderin like b.	Advillin.	0.456
LOC105920460	LOC105940068	ENSFHEP00000012985	ENSFHEP00000027682	Scinderin like b.	Scinderin like a.	0.943
LOC105920460	capg	ENSFHEP00000012985	ENSFHEP00000021800	Scinderin like b.	Capping protein (actin filament), gelsolin-like b.	0.597
LOC105920460	gsn	ENSFHEP00000012985	ENSFHEP00000013416	Scinderin like b.	Gelsolin a.	0.905
LOC105920460	twf1	ENSFHEP00000012985	ENSFHEP00000020994	Scinderin like b.	Twinfilin actin-binding protein 1a.	0.435
LOC105920460	twf2	ENSFHEP00000012985	ENSFHEP00000017265	Scinderin like b.	Twinfilin actin-binding protein 2a.	0.435