(51 nodes) Protein homotetramerization network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	crtc1	CREB regulated transcription coactivator 1b. (607 aa)
	LOC105925259	4-trimethylaminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (518 aa)
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (313 aa)
	ENSFHEP00000015728	SHMT domain-containing protein. (48 aa)
	LOC105928603	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
	LOC105928604	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	sycp1	Synaptonemal complex protein 1. (960 aa)
	trpa1	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family. (1104 aa)
	crtc3	CREB regulated transcription coactivator 3. (698 aa)
	samhd1	SAM domain and HD domain 1. (568 aa)
	tk1	Thymidine kinase. (236 aa)
	LOC105929101	Enah/Vasp-like b. (357 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (512 aa)
	ENSFHEP00000019366	TORC_N domain-containing protein. (80 aa)
	LOC105928945	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
	cryz	Crystallin, zeta (quinone reductase). (328 aa)
	ENSFHEP00000021849	SHMT domain-containing protein. (169 aa)
	ssbp1	Single-stranded DNA-binding protein, mitochondrial. (147 aa)
	LOC105928640	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (299 aa)
	ENSFHEP00000024465	TORC_N domain-containing protein. (71 aa)
	usp16	Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. (842 aa)
	ENSFHEP00000025239	tRNA-histidine guanylyltransferase 1-like. (157 aa)
	LOC105927771	Acetyl-CoA carboxylase alpha. (2337 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (367 aa)
	LOC105920246	ATP synthase inhibitory factor subunit 1b. (107 aa)
	cby1	Chibby homolog 1 (Drosophila). (125 aa)
	LOC105939926	Inward rectifier potassium channel 4. (423 aa)
	ENSFHEP00000030739	SHMT domain-containing protein. (88 aa)
	vasp	Vasodilator stimulated phosphoprotein b. (405 aa)
	trpv5	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family. (728 aa)
	acot13	Acyl-CoA thioesterase 13. (142 aa)
	acacb	Acetyl-CoA carboxylase beta. (2298 aa)
	LOC105919968	Potassium inwardly-rectifying channel, subfamily J, member 12a. (441 aa)
	enah	ENAH actin regulator. (854 aa)
	LOC105916055	SHMT domain-containing protein. (483 aa)
	ENSFHEP00000026271	LSDAT_euk domain-containing protein. (233 aa)
	ENSFHEP00000026205	Ion_trans domain-containing protein. (268 aa)
	ENSFHEP00000026146	LSDAT_euk domain-containing protein. (189 aa)
	ENSFHEP00000026093	Ion_trans domain-containing protein. (320 aa)
	upb1	Ureidopropionase, beta. (399 aa)
	ENSFHEP00000005073	CREB regulated transcription coactivator 1a. (322 aa)
	LOC105920115	Polycystic kidney disease 2-like 1. (806 aa)
	LOC105927671	Enah/Vasp-like. (698 aa)
	tdo2	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (404 aa)
	ENSFHEP00000007693	Uncharacterized protein. (233 aa)
	hsd17b10	Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	LOC105916057	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
	kcnj2	Potassium inwardly-rectifying channel, subfamily J, member 2a. (427 aa)
	ENSFHEP00000011171	Potassium inwardly-rectifying channel, subfamily J, member 2b. (431 aa)
	gnmt	Uncharacterized protein. (403 aa)
	LOC105915946	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (461 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP4	LOC105928604	ENSFHEP00000014121	ENSFHEP00000016079	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.599
AQP4	LOC105928945	ENSFHEP00000014121	ENSFHEP00000020874	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Major intrinsic protein of lens fiber a; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.599
ENSFHEP00000007693	ENSFHEP00000026093	ENSFHEP00000007693	ENSFHEP00000026093	Uncharacterized protein.	Ion_trans domain-containing protein.	0.951
ENSFHEP00000007693	ENSFHEP00000026146	ENSFHEP00000007693	ENSFHEP00000026146	Uncharacterized protein.	LSDAT_euk domain-containing protein.	0.956
ENSFHEP00000007693	ENSFHEP00000026205	ENSFHEP00000007693	ENSFHEP00000026205	Uncharacterized protein.	Ion_trans domain-containing protein.	0.951
ENSFHEP00000007693	ENSFHEP00000026271	ENSFHEP00000007693	ENSFHEP00000026271	Uncharacterized protein.	LSDAT_euk domain-containing protein.	0.804
ENSFHEP00000007693	trpa1	ENSFHEP00000007693	ENSFHEP00000016308	Uncharacterized protein.	Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.	0.785
ENSFHEP00000007693	trpv5	ENSFHEP00000007693	ENSFHEP00000029796	Uncharacterized protein.	Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.	0.798
ENSFHEP00000015728	LOC105915946	ENSFHEP00000015728	ENSFHEP00000012554	SHMT domain-containing protein.	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family.	0.571
ENSFHEP00000015728	LOC105925259	ENSFHEP00000015728	ENSFHEP00000013580	SHMT domain-containing protein.	4-trimethylaminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.571
ENSFHEP00000015728	gnmt	ENSFHEP00000015728	ENSFHEP00000011961	SHMT domain-containing protein.	Uncharacterized protein.	0.912
ENSFHEP00000015728	tk1	ENSFHEP00000015728	ENSFHEP00000017289	SHMT domain-containing protein.	Thymidine kinase.	0.447
ENSFHEP00000021849	LOC105915946	ENSFHEP00000021849	ENSFHEP00000012554	SHMT domain-containing protein.	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family.	0.571
ENSFHEP00000021849	LOC105916055	ENSFHEP00000021849	ENSFHEP00000027456	SHMT domain-containing protein.	SHMT domain-containing protein.	0.902
ENSFHEP00000021849	LOC105916057	ENSFHEP00000021849	ENSFHEP00000009641	SHMT domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.902
ENSFHEP00000021849	LOC105925259	ENSFHEP00000021849	ENSFHEP00000013580	SHMT domain-containing protein.	4-trimethylaminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.571
ENSFHEP00000021849	LOC105928640	ENSFHEP00000021849	ENSFHEP00000023227	SHMT domain-containing protein.	Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.	0.637
ENSFHEP00000021849	gnmt	ENSFHEP00000021849	ENSFHEP00000011961	SHMT domain-containing protein.	Uncharacterized protein.	0.958
ENSFHEP00000021849	shmt1	ENSFHEP00000021849	ENSFHEP00000019297	SHMT domain-containing protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.901
ENSFHEP00000021849	tk1	ENSFHEP00000021849	ENSFHEP00000017289	SHMT domain-containing protein.	Thymidine kinase.	0.528