(41 nodes) Actin filament capping network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105940068	Scinderin like a. (718 aa)
	LOC105935352	Spectrin beta chain; Belongs to the spectrin family. (2168 aa)
	ENSFHEP00000005405	Si:zfos-1837d3.1. (198 aa)
	svil	Supervillin a. (1875 aa)
	ENSFHEP00000024927	Uncharacterized protein. (412 aa)
	add2	Adducin 2 (beta). (643 aa)
	LOC105920460	Scinderin like b. (720 aa)
	gsn	Gelsolin a. (740 aa)
	lmod1	Leiomodin 1b (smooth muscle). (670 aa)
	LOC105939416	Supervillin d. (1490 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2118 aa)
	LMOD3	Leiomodin 3. (633 aa)
	ENSFHEP00000005904	EFhand_Ca_insen domain-containing protein. (453 aa)
	LOC105939099	Advillin. (818 aa)
	ENSFHEP00000006982	Gelsolin-like domain-containing protein. (102 aa)
	LOC105936506	Uncharacterized protein. (110 aa)
	LOC105916477	Supervillin c. (1551 aa)
	SPTBN1-2	Spectrin beta, non-erythrocytic 1. (893 aa)
	add3	Adducin 3 (gamma) a. (684 aa)
	vill	Villin-like. (843 aa)
	twf2	Twinfilin actin-binding protein 2a. (446 aa)
	capza1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	LOC105927285	Adducin 3 (gamma) b. (620 aa)
	sptbn4	Spectrin beta chain; Belongs to the spectrin family. (2450 aa)
	tmod4	Tropomodulin 4 (muscle). (309 aa)
	twf1	Twinfilin actin-binding protein 1a. (350 aa)
	capg	Capping protein (actin filament), gelsolin-like b. (363 aa)
	ENSFHEP00000012048	Uncharacterized protein. (253 aa)
	ENSFHEP00000012057	HP domain-containing protein. (87 aa)
	ENSFHEP00000012245	Tropomodulin 1. (301 aa)
	lmod2	Leiomodin 2 (cardiac) b. (568 aa)
	LOC105916020	Alpha-fodrin Xen alpha. (1799 aa)
	flii	FLII actin remodeling protein. (1273 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (274 aa)
	add1	Adducin 1 (alpha). (822 aa)
	LOC105929365	Spectrin beta chain; Belongs to the spectrin family. (2380 aa)
	LOC105927192	Twinfilin actin-binding protein 2b. (372 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (316 aa)
	tmod3	Tropomodulin 2. (439 aa)
	ENSFHEP00000028317	Uncharacterized protein. (671 aa)
	ENSFHEP00000027806	HP domain-containing protein. (84 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPZA2	LOC105927192	ENSFHEP00000026870	ENSFHEP00000023379	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 2b.	0.663
CAPZA2	capza1	ENSFHEP00000026870	ENSFHEP00000018011	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.968
CAPZA2	capzb	ENSFHEP00000026870	ENSFHEP00000004080	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.995
CAPZA2	twf1	ENSFHEP00000026870	ENSFHEP00000020994	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 1a.	0.663
CAPZA2	twf2	ENSFHEP00000026870	ENSFHEP00000017265	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Twinfilin actin-binding protein 2a.	0.663
ENSFHEP00000005405	ENSFHEP00000005904	ENSFHEP00000005405	ENSFHEP00000005904	Si:zfos-1837d3.1.	EFhand_Ca_insen domain-containing protein.	0.869
ENSFHEP00000005405	ENSFHEP00000024927	ENSFHEP00000005405	ENSFHEP00000024927	Si:zfos-1837d3.1.	Uncharacterized protein.	0.869
ENSFHEP00000005405	ENSFHEP00000028317	ENSFHEP00000005405	ENSFHEP00000028317	Si:zfos-1837d3.1.	Uncharacterized protein.	0.938
ENSFHEP00000005405	SPTBN1	ENSFHEP00000005405	ENSFHEP00000005460	Si:zfos-1837d3.1.	Spectrin beta chain; Belongs to the spectrin family.	0.937
ENSFHEP00000005904	ENSFHEP00000005405	ENSFHEP00000005904	ENSFHEP00000005405	EFhand_Ca_insen domain-containing protein.	Si:zfos-1837d3.1.	0.869
ENSFHEP00000005904	ENSFHEP00000024927	ENSFHEP00000005904	ENSFHEP00000024927	EFhand_Ca_insen domain-containing protein.	Uncharacterized protein.	0.915
ENSFHEP00000005904	ENSFHEP00000028317	ENSFHEP00000005904	ENSFHEP00000028317	EFhand_Ca_insen domain-containing protein.	Uncharacterized protein.	0.954
ENSFHEP00000005904	LOC105916020	ENSFHEP00000005904	ENSFHEP00000028365	EFhand_Ca_insen domain-containing protein.	Alpha-fodrin Xen alpha.	0.869
ENSFHEP00000005904	LOC105929365	ENSFHEP00000005904	ENSFHEP00000022926	EFhand_Ca_insen domain-containing protein.	Spectrin beta chain; Belongs to the spectrin family.	0.948
ENSFHEP00000005904	LOC105935352	ENSFHEP00000005904	ENSFHEP00000032353	EFhand_Ca_insen domain-containing protein.	Spectrin beta chain; Belongs to the spectrin family.	0.869
ENSFHEP00000005904	SPTBN1	ENSFHEP00000005904	ENSFHEP00000005460	EFhand_Ca_insen domain-containing protein.	Spectrin beta chain; Belongs to the spectrin family.	0.869
ENSFHEP00000005904	SPTBN1-2	ENSFHEP00000005904	ENSFHEP00000011057	EFhand_Ca_insen domain-containing protein.	Spectrin beta, non-erythrocytic 1.	0.869
ENSFHEP00000005904	sptbn4	ENSFHEP00000005904	ENSFHEP00000018136	EFhand_Ca_insen domain-containing protein.	Spectrin beta chain; Belongs to the spectrin family.	0.869
ENSFHEP00000006982	LOC105920460	ENSFHEP00000006982	ENSFHEP00000012985	Gelsolin-like domain-containing protein.	Scinderin like b.	0.902
ENSFHEP00000006982	LOC105927192	ENSFHEP00000006982	ENSFHEP00000023379	Gelsolin-like domain-containing protein.	Twinfilin actin-binding protein 2b.	0.478