(17 nodes) Negative regulation of protein kinase B signaling network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	phlda1	Pleckstrin homology-like domain, family A, member 1. (282 aa)
	sh2b3	SH2B adaptor protein 3. (717 aa)
	ENSFHEP00000032057	Uncharacterized protein. (959 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (474 aa)
	flcn	Folliculin. (564 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	sirt1	Sirtuin 1. (719 aa)
	phlda3	Pleckstrin homology-like domain, family A, member 3. (147 aa)
	LOC105926111	Peptidase S72 domain-containing protein. (916 aa)
	ddit3	DNA-damage-inducible transcript 3. (313 aa)
	otud3	OTU deubiquitinase 3. (358 aa)
	dag1	Dystroglycan 1. (869 aa)
	LOC105920636	Uncharacterized protein. (362 aa)
	tsc2	TSC complex subunit 2. (1700 aa)
	LOC105939100	Growth differentiation factor 11. (356 aa)
	LOC105935574	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	ENSFHEP00000002273	PDZ domain-containing protein. (156 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	PDZ domain-containing protein.	Uncharacterized protein.	0.560
ENSFHEP00000002273	LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	PDZ domain-containing protein.	Uncharacterized protein.	0.586
ENSFHEP00000032057	ENSFHEP00000002273	ENSFHEP00000032057	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.560
LOC105920636	ENSFHEP00000002273	ENSFHEP00000008931	ENSFHEP00000002273	Uncharacterized protein.	PDZ domain-containing protein.	0.586
LOC105926111	dag1	ENSFHEP00000022393	ENSFHEP00000010968	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.969
dag1	LOC105926111	ENSFHEP00000010968	ENSFHEP00000022393	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.969
flcn	tsc2	ENSFHEP00000030845	ENSFHEP00000008712	Folliculin.	TSC complex subunit 2.	0.554
sirt1	tsc2	ENSFHEP00000025372	ENSFHEP00000008712	Sirtuin 1.	TSC complex subunit 2.	0.636
tsc2	flcn	ENSFHEP00000008712	ENSFHEP00000030845	TSC complex subunit 2.	Folliculin.	0.554
tsc2	sirt1	ENSFHEP00000008712	ENSFHEP00000025372	TSC complex subunit 2.	Sirtuin 1.	0.636