(64 nodes) Retina morphogenesis in camera-type eye network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	bhlhe23	Basic helix-loop-helix family, member e23. (227 aa)
	ENSFHEP00000001856	Ig-like domain-containing protein. (240 aa)
	sdk1	Uncharacterized protein. (1472 aa)
	crb1	Crumbs cell polarity complex component 1. (1328 aa)
	LOC105936808	Retinal homeobox gene 1. (332 aa)
	RING1	Ring finger protein 1. (388 aa)
	ENSFHEP00000006781	Reticulon 4 interacting protein 1. (355 aa)
	ENSFHEP00000009379	Uncharacterized protein. (1078 aa)
	vax1	Ventral anterior homeobox 1. (285 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (381 aa)
	LOC105918108	Uncharacterized protein. (263 aa)
	impg2	Interphotoreceptor matrix proteoglycan 2a. (348 aa)
	LOC105917049	Uncharacterized protein. (1411 aa)
	tspan12	Tetraspanin. (309 aa)
	LOC105938950	Forkhead box Q2. (220 aa)
	tatdn1	TatD DNase domain containing 1. (314 aa)
	med24	Mediator complex subunit 24. (989 aa)
	foxn4	Forkhead box N4. (517 aa)
	ENSFHEP00000013221	Forkhead box C1. (225 aa)
	bbs4	Bardet-Biedl syndrome 4. (544 aa)
	ENSFHEP00000014492	RP1 axonemal microtubule associated. (239 aa)
	ENSFHEP00000014699	Uncharacterized protein. (673 aa)
	ttc8	Tetratricopeptide repeat domain 8. (505 aa)
	fat3	FAT atypical cadherin 3a. (4516 aa)
	LOC105930785	T-box transcription factor 5a. (524 aa)
	ENSFHEP00000016962	RPGRIP1 like. (885 aa)
	vax2	Ventral anterior homeobox 2. (304 aa)
	ENSFHEP00000019204	Uncharacterized protein. (177 aa)
	LOC105917348	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	gdf5	Growth differentiation factor 5. (487 aa)
	rorb	RAR-related orphan receptor B. (479 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	naglu	N-acetylglucosaminidase, alpha. (783 aa)
	LOC105924100	Uncharacterized protein. (585 aa)
	alcam	Activated leukocyte cell adhesion molecule b. (563 aa)
	lhx1	LIM homeobox 1a. (407 aa)
	FOXC1	Forkhead box C1. (439 aa)
	atoh7	Atonal bHLH transcription factor 7. (143 aa)
	med27	Mediator complex subunit 27. (311 aa)
	ENSFHEP00000025589	Uncharacterized protein. (280 aa)
	ENSFHEP00000025615	Uncharacterized protein. (255 aa)
	gdf6	Growth differentiation factor 6a. (414 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	rnf2	Ring finger protein 2. (314 aa)
	fjx1	Four-jointed box protein 1. (427 aa)
	poc1b	POC1 centriolar protein B. (491 aa)
	ush1c	Usher syndrome 1C. (499 aa)
	LOC105915352	Crumbs cell polarity complex component 2b. (1448 aa)
	rp2	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (370 aa)
	RS1	Retinoschisin 1. (180 aa)
	LOC105932008	Sidekick cell adhesion molecule 2a. (2136 aa)
	LOC105919044	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	LOC105928020	Uncharacterized protein. (1537 aa)
	ENSFHEP00000031212	Immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 3. (525 aa)
	LOC105940364	Uncharacterized protein. (232 aa)
	LOC105928019	Immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 2. (1164 aa)
	LOC105922684	FAT atypical cadherin 3b. (4367 aa)
	thrb	Thyroid hormone receptor beta. (395 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	LOC105932512	Sidekick cell adhesion molecule 2b. (2181 aa)
	ahi1	Abelson helper integration site 1. (1202 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH2	fjx1	ENSFHEP00000030344	ENSFHEP00000026842	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Four-jointed box protein 1.	0.605
CDH2	ush1c	ENSFHEP00000030344	ENSFHEP00000027704	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Usher syndrome 1C.	0.485
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000001856	sdk1	ENSFHEP00000001856	ENSFHEP00000001859	Ig-like domain-containing protein.	Uncharacterized protein.	0.930
ENSFHEP00000006781	med24	ENSFHEP00000006781	ENSFHEP00000011111	Reticulon 4 interacting protein 1.	Mediator complex subunit 24.	0.509
ENSFHEP00000014492	ttc8	ENSFHEP00000014492	ENSFHEP00000015739	RP1 axonemal microtubule associated.	Tetratricopeptide repeat domain 8.	0.416
ENSFHEP00000014699	LOC105917348	ENSFHEP00000014699	ENSFHEP00000019674	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.710
ENSFHEP00000014699	mpp5	ENSFHEP00000014699	ENSFHEP00000022897	Uncharacterized protein.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.710
ENSFHEP00000016962	ahi1	ENSFHEP00000016962	ENSFHEP00000000782	RPGRIP1 like.	Abelson helper integration site 1.	0.647
ENSFHEP00000016962	bbs4	ENSFHEP00000016962	ENSFHEP00000013627	RPGRIP1 like.	Bardet-Biedl syndrome 4.	0.512
ENSFHEP00000019204	LOC105940364	ENSFHEP00000019204	ENSFHEP00000031252	Uncharacterized protein.	Uncharacterized protein.	0.416
ENSFHEP00000019204	ahi1	ENSFHEP00000019204	ENSFHEP00000000782	Uncharacterized protein.	Abelson helper integration site 1.	0.455
ENSFHEP00000025589	ENSFHEP00000025615	ENSFHEP00000025589	ENSFHEP00000025615	Uncharacterized protein.	Uncharacterized protein.	0.812
ENSFHEP00000025615	ENSFHEP00000025589	ENSFHEP00000025615	ENSFHEP00000025589	Uncharacterized protein.	Uncharacterized protein.	0.812
LOC105915352	LOC105917348	ENSFHEP00000028044	ENSFHEP00000019674	Crumbs cell polarity complex component 2b.	Uncharacterized protein; Belongs to the MAGUK family.	0.710
LOC105915352	mpp5	ENSFHEP00000028044	ENSFHEP00000022897	Crumbs cell polarity complex component 2b.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.710
LOC105917049	LOC105917348	ENSFHEP00000010655	ENSFHEP00000019674	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.710
LOC105917049	mpp5	ENSFHEP00000010655	ENSFHEP00000022897	Uncharacterized protein.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.710
LOC105917348	ENSFHEP00000014699	ENSFHEP00000019674	ENSFHEP00000014699	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.710
LOC105917348	LOC105915352	ENSFHEP00000019674	ENSFHEP00000028044	Uncharacterized protein; Belongs to the MAGUK family.	Crumbs cell polarity complex component 2b.	0.710