(22 nodes) Definitive hemopoiesis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000031731	BHLH domain-containing protein. (97 aa)
	sae1	SUMO1 activating enzyme subunit 1. (384 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (515 aa)
	LOC105937167	Ubiquitin-like domain-containing protein. (133 aa)
	gar1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (214 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1040 aa)
	LOC105939042	Small ubiquitin like modifier 3. (158 aa)
	ENSFHEP00000008666	BHLH domain-containing protein. (105 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	adar	Adenosine deaminase RNA specific. (1356 aa)
	rps24	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (139 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	LOC105933585	Small ubiquitin-related modifier. (96 aa)
	SP3	Sp3a transcription factor. (699 aa)
	LOC105939045	Sp3b transcription factor. (648 aa)
	kri1	KRI1 homolog. (787 aa)
	LOC105916074	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	LOC105934952	Microfibril associated protein 5. (179 aa)
	cbfb	Core-binding factor subunit beta. (174 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000008666	cbfb	ENSFHEP00000008666	ENSFHEP00000031734	BHLH domain-containing protein.	Core-binding factor subunit beta.	0.705
ENSFHEP00000022320	cbfb	ENSFHEP00000022320	ENSFHEP00000031734	BHLH domain-containing protein.	Core-binding factor subunit beta.	0.716
ENSFHEP00000031731	cbfb	ENSFHEP00000031731	ENSFHEP00000031734	BHLH domain-containing protein.	Core-binding factor subunit beta.	0.705
LOC105916074	LOC105933585	ENSFHEP00000027147	ENSFHEP00000023052	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.987
LOC105916074	LOC105937167	ENSFHEP00000027147	ENSFHEP00000006742	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.976
LOC105916074	LOC105939042	ENSFHEP00000027147	ENSFHEP00000008597	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin like modifier 3.	0.988
LOC105916074	adar	ENSFHEP00000027147	ENSFHEP00000019192	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Adenosine deaminase RNA specific.	0.443
LOC105916074	sae1	ENSFHEP00000027147	ENSFHEP00000001537	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	SUMO1 activating enzyme subunit 1.	0.975
LOC105916074	sumo1	ENSFHEP00000027147	ENSFHEP00000015878	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.998
LOC105916074	sumo2	ENSFHEP00000027147	ENSFHEP00000002112	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Small ubiquitin-related modifier.	0.988
LOC105916074	ube2i	ENSFHEP00000027147	ENSFHEP00000021039	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.	0.947
LOC105933585	LOC105916074	ENSFHEP00000023052	ENSFHEP00000027147	Small ubiquitin-related modifier.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.987
LOC105933585	LOC105939042	ENSFHEP00000023052	ENSFHEP00000008597	Small ubiquitin-related modifier.	Small ubiquitin like modifier 3.	0.900
LOC105933585	sae1	ENSFHEP00000023052	ENSFHEP00000001537	Small ubiquitin-related modifier.	SUMO1 activating enzyme subunit 1.	0.965
LOC105933585	sumo1	ENSFHEP00000023052	ENSFHEP00000015878	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.828
LOC105933585	sumo2	ENSFHEP00000023052	ENSFHEP00000002112	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.900
LOC105933585	ube2i	ENSFHEP00000023052	ENSFHEP00000021039	Small ubiquitin-related modifier.	Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family.	0.985
LOC105935913	cbfb	ENSFHEP00000032272	ENSFHEP00000031734	T-cell acute lymphocytic leukemia protein 1.	Core-binding factor subunit beta.	0.716
LOC105937167	LOC105916074	ENSFHEP00000006742	ENSFHEP00000027147	Ubiquitin-like domain-containing protein.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.976
LOC105937167	sae1	ENSFHEP00000006742	ENSFHEP00000001537	Ubiquitin-like domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.958