(14 nodes) Hematopoietic stem cell differentiation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	meox1	Homeobox protein MOX-1. (265 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	srf	Serum response factor b. (599 aa)
	ercc2	TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
	ENSFHEP00000022320	BHLH domain-containing protein. (129 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	ufl1	UFM1-specific ligase 1. (795 aa)
	ENSFHEP00000024754	FEV transcription factor, ETS family member. (160 aa)
	LOC105930009	Notch receptor 1a. (2479 aa)
	LOC105935913	T-cell acute lymphocytic leukemia protein 1. (478 aa)
	sh2b3	SH2B adaptor protein 3. (717 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (1040 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (124 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000024754	LOC105924010	ENSFHEP00000024754	ENSFHEP00000004618	FEV transcription factor, ETS family member.	Uncharacterized protein.	0.556
ENSFHEP00000024754	srf	ENSFHEP00000024754	ENSFHEP00000013718	FEV transcription factor, ETS family member.	Serum response factor b.	0.556
LOC105924010	ENSFHEP00000024754	ENSFHEP00000004618	ENSFHEP00000024754	Uncharacterized protein.	FEV transcription factor, ETS family member.	0.556
LOC105924010	srf	ENSFHEP00000004618	ENSFHEP00000013718	Uncharacterized protein.	Serum response factor b.	0.933
ercc2	xrcc5	ENSFHEP00000022071	ENSFHEP00000025953	TFIIH basal transcription factor complex helicase XPD subunit.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.592
srf	ENSFHEP00000024754	ENSFHEP00000013718	ENSFHEP00000024754	Serum response factor b.	FEV transcription factor, ETS family member.	0.556
srf	LOC105924010	ENSFHEP00000013718	ENSFHEP00000004618	Serum response factor b.	Uncharacterized protein.	0.933
xrcc5	ercc2	ENSFHEP00000025953	ENSFHEP00000022071	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	TFIIH basal transcription factor complex helicase XPD subunit.	0.592