(18 nodes) Lung morphogenesis network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	stk40	Serine/threonine-protein kinase 40. (436 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
	LOC105932234	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (271 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	ENSFHEP00000006232	Uncharacterized protein. (509 aa)
	ctsz	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (303 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	dag1	Dystroglycan 1. (869 aa)
	srf	Serum response factor b. (599 aa)
	LOC105938701	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2023 aa)
	hps1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (676 aa)
	LOC105926111	Peptidase S72 domain-containing protein. (916 aa)
	LOC105920957	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	tcf21	Transcription factor 21. (175 aa)
	hhip	Hedgehog interacting protein. (739 aa)
	LOC105935995	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	LOC105932547	Sprouty RTK signaling antagonist 2. (347 aa)
	LOC105931906	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (301 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000006232	LOC105926111	ENSFHEP00000006232	ENSFHEP00000022393	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.773
ENSFHEP00000006232	dag1	ENSFHEP00000006232	ENSFHEP00000010968	Uncharacterized protein.	Dystroglycan 1.	0.773
LOC105924010	srf	ENSFHEP00000004618	ENSFHEP00000013718	Uncharacterized protein.	Serum response factor b.	0.933
LOC105926111	ENSFHEP00000006232	ENSFHEP00000022393	ENSFHEP00000006232	Peptidase S72 domain-containing protein.	Uncharacterized protein.	0.773
LOC105926111	dag1	ENSFHEP00000022393	ENSFHEP00000010968	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.969
LOC105931906	ctsh	ENSFHEP00000033503	ENSFHEP00000001836	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.721
LOC105932234	ctsh	ENSFHEP00000003848	ENSFHEP00000001836	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.721
ctsh	LOC105931906	ENSFHEP00000001836	ENSFHEP00000033503	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.721
ctsh	LOC105932234	ENSFHEP00000001836	ENSFHEP00000003848	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.721
ctsh	ctsz	ENSFHEP00000001836	ENSFHEP00000006513	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.721
ctsz	ctsh	ENSFHEP00000006513	ENSFHEP00000001836	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.721
dag1	ENSFHEP00000006232	ENSFHEP00000010968	ENSFHEP00000006232	Dystroglycan 1.	Uncharacterized protein.	0.773
dag1	LOC105926111	ENSFHEP00000010968	ENSFHEP00000022393	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.969
srf	LOC105924010	ENSFHEP00000013718	ENSFHEP00000004618	Serum response factor b.	Uncharacterized protein.	0.933