(77 nodes) Morphogenesis of a branching epithelium network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000012835	EF-hand domain-containing protein. (73 aa)
	LOC105921341	MH2 domain-containing protein. (222 aa)
	ENSFHEP00000034755	MH1 domain-containing protein. (154 aa)
	LOC105931906	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (301 aa)
	wt1	WT1 transcription factor b. (423 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
	gbx2	Gastrulation brain homeobox 2. (348 aa)
	LOC105930774	Mothers against decapentaplegic homolog. (393 aa)
	LOC105932547	Sprouty RTK signaling antagonist 2. (347 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	LOC105915787	Integrin linked kinase. (452 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (357 aa)
	fem1b	Fem-1 homolog b (C. elegans). (627 aa)
	LOC105925696	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (465 aa)
	LOC105923645	Endothelin 1. (218 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1600 aa)
	ENSFHEP00000027841	Uncharacterized protein. (221 aa)
	lrp6	Low density lipoprotein receptor-related protein 6. (784 aa)
	LOC105928217	Suppressor of cytokine signaling 3. (215 aa)
	LOC105936197	Suppressor of cytokine signaling 3a. (196 aa)
	ENSFHEP00000026218	Uncharacterized protein. (251 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	hhip	Hedgehog interacting protein. (739 aa)
	tcf21	Transcription factor 21. (175 aa)
	lef1	Lymphoid enhancer-binding factor 1. (424 aa)
	LOC105935688	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
	nfatc4	Nuclear factor of activated T cells 4. (897 aa)
	LOC105926065	Colony stimulating factor 1b (macrophage). (299 aa)
	LOC105926111	Peptidase S72 domain-containing protein. (916 aa)
	AR	Androgen receptor. (752 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC105931285	Androgen receptor. (683 aa)
	tmem59l	Transmembrane protein 59-like. (340 aa)
	LOC105929601	WT1 transcription factor a. (430 aa)
	il10	Interleukin 10. (268 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC105938701	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2023 aa)
	mks1	MKS transition zone complex subunit 1. (506 aa)
	ENSFHEP00000019104	Uncharacterized protein. (105 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	bmp4	Bone morphogenetic protein 4. (399 aa)
	ENSFHEP00000016311	Musculin (activated B-cell factor-1). (149 aa)
	LOC105930872	SRY-box transcription factor 9a. (494 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	srf	Serum response factor b. (599 aa)
	sars1	Seryl-tRNA synthetase. (514 aa)
	LOC105919313	Uncharacterized protein. (194 aa)
	LOC105920529	Mothers against decapentaplegic homolog. (520 aa)
	dag1	Dystroglycan 1. (869 aa)
	LOC105920824	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	nrarp	NOTCH regulated ankyrin repeat protein a. (112 aa)
	btbd7	BTB (POZ) domain containing 7. (1114 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	pkd1	Polycystic kidney disease 1a. (4308 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	LOC105918838	Uncharacterized protein. (417 aa)
	ENSFHEP00000007869	SH2 domain-containing protein. (192 aa)
	ENSFHEP00000007274	MANSC domain-containing protein. (199 aa)
	LOC105936190	SRY-box transcription factor 9b. (476 aa)
	ednra	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	timeless	Timeless circadian clock. (1259 aa)
	SOX10	SRY-box transcription factor 10. (504 aa)
	ctsz	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (303 aa)
	ENSFHEP00000006232	Uncharacterized protein. (509 aa)
	LOC105921308	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (410 aa)
	LOC105939150	Bone morphogenetic protein 16. (476 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	sox10	SRY-box transcription factor 10. (452 aa)
	LOC105932234	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (271 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (887 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
	LOC105919668	Transmembrane p24 trafficking protein 2. (116 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (163 aa)
	LOC105940274	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (673 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	LOC105931285	ENSFHEP00000022152	ENSFHEP00000021977	Androgen receptor.	Androgen receptor.	0.948
AR	med1	ENSFHEP00000022152	ENSFHEP00000014059	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.689
AR	nkx3-1	ENSFHEP00000022152	ENSFHEP00000032519	Androgen receptor.	NK3 homeobox 1.	0.564
ENSFHEP00000006232	LOC105926111	ENSFHEP00000006232	ENSFHEP00000022393	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.773
ENSFHEP00000006232	dag1	ENSFHEP00000006232	ENSFHEP00000010968	Uncharacterized protein.	Dystroglycan 1.	0.773
ENSFHEP00000007274	hhip	ENSFHEP00000007274	ENSFHEP00000025527	MANSC domain-containing protein.	Hedgehog interacting protein.	0.407
ENSFHEP00000007869	LOC105928217	ENSFHEP00000007869	ENSFHEP00000027219	SH2 domain-containing protein.	Suppressor of cytokine signaling 3.	0.757
ENSFHEP00000007869	il10	ENSFHEP00000007869	ENSFHEP00000019709	SH2 domain-containing protein.	Interleukin 10.	0.402
ENSFHEP00000012835	nfatc4	ENSFHEP00000012835	ENSFHEP00000023571	EF-hand domain-containing protein.	Nuclear factor of activated T cells 4.	0.917
ENSFHEP00000027841	LOC105923386	ENSFHEP00000027841	ENSFHEP00000002289	Uncharacterized protein.	Secreted frizzled-related protein 2 like.	0.418
ENSFHEP00000027841	lrp5	ENSFHEP00000027841	ENSFHEP00000029110	Uncharacterized protein.	Low density lipoprotein receptor-related protein 5.	0.906
ENSFHEP00000027841	sfrp2	ENSFHEP00000027841	ENSFHEP00000022060	Uncharacterized protein.	Secreted frizzled-related protein 2.	0.418
ENSFHEP00000027841	wnt6	ENSFHEP00000027841	ENSFHEP00000005563	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.935
ENSFHEP00000034755	LOC105920529	ENSFHEP00000034755	ENSFHEP00000011523	MH1 domain-containing protein.	Mothers against decapentaplegic homolog.	0.715
ENSFHEP00000034755	LOC105921341	ENSFHEP00000034755	ENSFHEP00000034764	MH1 domain-containing protein.	MH2 domain-containing protein.	0.927
ENSFHEP00000034755	LOC105933078	ENSFHEP00000034755	ENSFHEP00000019375	MH1 domain-containing protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.751
ENSFHEP00000034755	LOC105939150	ENSFHEP00000034755	ENSFHEP00000005655	MH1 domain-containing protein.	Bone morphogenetic protein 16.	0.757
ENSFHEP00000034755	LOC105940274	ENSFHEP00000034755	ENSFHEP00000000824	MH1 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.699
ENSFHEP00000034755	TGFBR2	ENSFHEP00000034755	ENSFHEP00000008661	MH1 domain-containing protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.839
ENSFHEP00000034755	bmp2	ENSFHEP00000034755	ENSFHEP00000018050	MH1 domain-containing protein.	Bone morphogenetic protein 2b.	0.757