6 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105925555	Sestrin 2. (558 aa)
	LOC105925715	Si:zfos-80g12.1. (371 aa)
	sesn1	Sestrin 1. (548 aa)
	ENSFHEP00000009643	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (384 aa)
	ENSFHEP00000032875	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (395 aa)
	ubr2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1679 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009643	ENSFHEP00000032875	ENSFHEP00000009643	ENSFHEP00000032875	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.916
ENSFHEP00000032875	ENSFHEP00000009643	ENSFHEP00000032875	ENSFHEP00000009643	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.916
LOC105925555	LOC105925715	ENSFHEP00000025442	ENSFHEP00000030078	Sestrin 2.	Si:zfos-80g12.1.	0.951
LOC105925555	sesn1	ENSFHEP00000025442	ENSFHEP00000021298	Sestrin 2.	Sestrin 1.	0.954
LOC105925715	LOC105925555	ENSFHEP00000030078	ENSFHEP00000025442	Si:zfos-80g12.1.	Sestrin 2.	0.951
LOC105925715	sesn1	ENSFHEP00000030078	ENSFHEP00000021298	Si:zfos-80g12.1.	Sestrin 1.	0.947
sesn1	LOC105925555	ENSFHEP00000021298	ENSFHEP00000025442	Sestrin 1.	Sestrin 2.	0.954
sesn1	LOC105925715	ENSFHEP00000021298	ENSFHEP00000030078	Sestrin 1.	Si:zfos-80g12.1.	0.947