39 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AANAT-2	Arylalkylamine N-acetyltransferase 1. (204 aa)
	LOC105937876	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC105935996	Uncharacterized protein. (185 aa)
	LOC105919611	GATA binding protein 1a. (424 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (320 aa)
	rapgef3	Rap guanine nucleotide exchange factor (GEF) 3. (868 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1122 aa)
	LOC105930007	Rap guanine nucleotide exchange factor (GEF) 1b. (1097 aa)
	CYP1C1	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (529 aa)
	LOC105916552	Uncharacterized protein. (2218 aa)
	ENSFHEP00000009991	Uncharacterized protein. (306 aa)
	LOC105929941	N-acetyltransferase domain-containing protein. (222 aa)
	LOC105918962	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (624 aa)
	LOC105921164	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1. (287 aa)
	LOC105938942	Insulin-like growth factor binding protein 5a. (267 aa)
	LOC105918704	Ras-related protein Rap-1A. (184 aa)
	LOC105922967	Insulin-like growth factor binding protein 5a. (249 aa)
	akap7	Uncharacterized protein. (519 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1626 aa)
	HCN2	Hyperpolarization activated cyclic nucleotide-gated potassium channel 2b. (945 aa)
	LOC105931336	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	LOC105926177	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (546 aa)
	LOC105929601	WT1 transcription factor a. (430 aa)
	LOC105928494	Cyclic nucleotide-binding domain-containing protein. (1023 aa)
	LOC105934606	Cyclic nucleotide-binding domain-containing protein. (1056 aa)
	ENSFHEP00000022273	Uncharacterized protein; Belongs to the potassium channel family. (590 aa)
	LOC105937341	Arylalkylamine N-acetyltransferase 2. (207 aa)
	LOC105930685	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1. (619 aa)
	LOC105935262	RAP1A, member of RAS oncogene family a. (185 aa)
	ENSFHEP00000026175	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	aqp1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (294 aa)
	LOC105938486	Cyclic nucleotide-binding domain-containing protein. (1168 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (623 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (834 aa)
	LOC105920540	Uncharacterized protein. (271 aa)
	AANAT	Arylalkylamine N-acetyltransferase 1. (220 aa)
	aqp8	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	wt1	WT1 transcription factor b. (423 aa)
	LOC105930179	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4. (1433 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AANAT	LOC105929941	ENSFHEP00000028876	ENSFHEP00000010107	Arylalkylamine N-acetyltransferase 1.	N-acetyltransferase domain-containing protein.	0.904
AANAT	LOC105937341	ENSFHEP00000028876	ENSFHEP00000022349	Arylalkylamine N-acetyltransferase 1.	Arylalkylamine N-acetyltransferase 2.	0.905
AANAT	kdm1a	ENSFHEP00000028876	ENSFHEP00000028103	Arylalkylamine N-acetyltransferase 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.495
AANAT-2	LOC105929941	ENSFHEP00000028885	ENSFHEP00000010107	Arylalkylamine N-acetyltransferase 1.	N-acetyltransferase domain-containing protein.	0.903
AANAT-2	LOC105937341	ENSFHEP00000028885	ENSFHEP00000022349	Arylalkylamine N-acetyltransferase 1.	Arylalkylamine N-acetyltransferase 2.	0.904
AANAT-2	kdm1a	ENSFHEP00000028885	ENSFHEP00000028103	Arylalkylamine N-acetyltransferase 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.495
ENSFHEP00000009991	LOC105930685	ENSFHEP00000009991	ENSFHEP00000023648	Uncharacterized protein.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.	0.910
ENSFHEP00000022273	LOC105918962	ENSFHEP00000022273	ENSFHEP00000010295	Uncharacterized protein; Belongs to the potassium channel family.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.909
LOC105916552	akap7	ENSFHEP00000008232	ENSFHEP00000017122	Uncharacterized protein.	Uncharacterized protein.	0.616
LOC105916552	rapgef3	ENSFHEP00000008232	ENSFHEP00000005863	Uncharacterized protein.	Rap guanine nucleotide exchange factor (GEF) 3.	0.682
LOC105918704	LOC105930007	ENSFHEP00000012353	ENSFHEP00000007398	Ras-related protein Rap-1A.	Rap guanine nucleotide exchange factor (GEF) 1b.	0.960
LOC105918704	LOC105935262	ENSFHEP00000012353	ENSFHEP00000024043	Ras-related protein Rap-1A.	RAP1A, member of RAS oncogene family a.	0.947
LOC105918704	LOC105935996	ENSFHEP00000012353	ENSFHEP00000030994	Ras-related protein Rap-1A.	Uncharacterized protein.	0.947
LOC105918704	LOC105937876	ENSFHEP00000012353	ENSFHEP00000029146	Ras-related protein Rap-1A.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.580
LOC105918704	pik3cg	ENSFHEP00000012353	ENSFHEP00000006762	Ras-related protein Rap-1A.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.580
LOC105918704	rapgef2	ENSFHEP00000012353	ENSFHEP00000017162	Ras-related protein Rap-1A.	Rap guanine nucleotide exchange factor (GEF) 2.	0.928
LOC105918704	rapgef3	ENSFHEP00000012353	ENSFHEP00000005863	Ras-related protein Rap-1A.	Rap guanine nucleotide exchange factor (GEF) 3.	0.810
LOC105918962	ENSFHEP00000022273	ENSFHEP00000010295	ENSFHEP00000022273	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	Uncharacterized protein; Belongs to the potassium channel family.	0.909
LOC105921164	LOC105930685	ENSFHEP00000011752	ENSFHEP00000023648	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1.	0.899
LOC105929941	AANAT	ENSFHEP00000010107	ENSFHEP00000028876	N-acetyltransferase domain-containing protein.	Arylalkylamine N-acetyltransferase 1.	0.904