(27 nodes) Stem cell proliferation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	mecom	MDS1 and EVI1 complex locus. (1258 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (190 aa)
	bysl	Bystin-like. (443 aa)
	znrf3	Zinc and ring finger 3. (889 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (660 aa)
	lig4	DNA ligase. (1006 aa)
	brca2	BRCA2 DNA repair associated. (2841 aa)
	ENSFHEP00000013647	Uncharacterized protein. (100 aa)
	kdf1	Keratinocyte differentiation factor 1a. (394 aa)
	ETV6	ETS variant 6. (470 aa)
	trim71	Tripartite motif containing 71, E3 ubiquitin protein ligase. (830 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (578 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	cep120	Centrosomal protein 120. (839 aa)
	ENSFHEP00000019886	Uncharacterized protein. (184 aa)
	ism1	Isthmin 1. (451 aa)
	ercc2	TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
	nf1	Neurofibromin 1b. (2547 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	rnf43	RING-type domain-containing protein. (811 aa)
	ENSFHEP00000026670	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (127 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	arih2	RBR-type E3 ubiquitin transferase. (293 aa)
	ENSFHEP00000033024	Uncharacterized protein. (61 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105923386	rnf43	ENSFHEP00000002289	ENSFHEP00000026352	Secreted frizzled-related protein 2 like.	RING-type domain-containing protein.	0.563
LOC105923386	znrf3	ENSFHEP00000002289	ENSFHEP00000004230	Secreted frizzled-related protein 2 like.	Zinc and ring finger 3.	0.512
LOC105933078	fgf2	ENSFHEP00000019375	ENSFHEP00000031514	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.590
brca2	ercc2	ENSFHEP00000010259	ENSFHEP00000022071	BRCA2 DNA repair associated.	TFIIH basal transcription factor complex helicase XPD subunit.	0.824
brca2	lig4	ENSFHEP00000010259	ENSFHEP00000006360	BRCA2 DNA repair associated.	DNA ligase.	0.638
brca2	nf1	ENSFHEP00000010259	ENSFHEP00000022529	BRCA2 DNA repair associated.	Neurofibromin 1b.	0.572
brca2	xrcc5	ENSFHEP00000010259	ENSFHEP00000025953	BRCA2 DNA repair associated.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.605
ercc2	brca2	ENSFHEP00000022071	ENSFHEP00000010259	TFIIH basal transcription factor complex helicase XPD subunit.	BRCA2 DNA repair associated.	0.824
ercc2	lig4	ENSFHEP00000022071	ENSFHEP00000006360	TFIIH basal transcription factor complex helicase XPD subunit.	DNA ligase.	0.688
ercc2	xrcc5	ENSFHEP00000022071	ENSFHEP00000025953	TFIIH basal transcription factor complex helicase XPD subunit.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.592
fgf2	LOC105933078	ENSFHEP00000031514	ENSFHEP00000019375	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.590
lig4	brca2	ENSFHEP00000006360	ENSFHEP00000010259	DNA ligase.	BRCA2 DNA repair associated.	0.638
lig4	ercc2	ENSFHEP00000006360	ENSFHEP00000022071	DNA ligase.	TFIIH basal transcription factor complex helicase XPD subunit.	0.688
lig4	xrcc5	ENSFHEP00000006360	ENSFHEP00000025953	DNA ligase.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.993
mettl3	ythdf2	ENSFHEP00000015535	ENSFHEP00000005795	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.604
nf1	brca2	ENSFHEP00000022529	ENSFHEP00000010259	Neurofibromin 1b.	BRCA2 DNA repair associated.	0.572
rnf43	LOC105923386	ENSFHEP00000026352	ENSFHEP00000002289	RING-type domain-containing protein.	Secreted frizzled-related protein 2 like.	0.563
rnf43	sfrp2	ENSFHEP00000026352	ENSFHEP00000022060	RING-type domain-containing protein.	Secreted frizzled-related protein 2.	0.563
rnf43	znrf3	ENSFHEP00000026352	ENSFHEP00000004230	RING-type domain-containing protein.	Zinc and ring finger 3.	0.812
sfrp2	rnf43	ENSFHEP00000022060	ENSFHEP00000026352	Secreted frizzled-related protein 2.	RING-type domain-containing protein.	0.563