(86 nodes) Epithelial tube formation network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sall4	Spalt-like transcription factor 4. (1083 aa)
	ENSFHEP00000000835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (259 aa)
	dvl2	Dishevelled segment polarity protein 2. (766 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (163 aa)
	LOC105919668	Transmembrane p24 trafficking protein 2. (116 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1442 aa)
	LOC105923386	Secreted frizzled-related protein 2 like. (342 aa)
	hnf1b	Hepatocyte nuclear factor 1-beta-B. (566 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	ENSFHEP00000003392	Heart and neural crest derivatives expressed 2. (235 aa)
	abl2	Tyrosine-protein kinase. (1188 aa)
	hectd1	HECT domain containing 1. (2561 aa)
	LOC105933918	Phosphatase and Actin regulator 4A. (1247 aa)
	fst	Follistatin a. (349 aa)
	irx3	Iroquois homeobox 3a. (431 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	LOC105932862	Phosphatase and actin regulator. (607 aa)
	ENSFHEP00000007274	MANSC domain-containing protein. (199 aa)
	tctn1	DUF1619 domain-containing protein. (611 aa)
	ENSFHEP00000007623	Uncharacterized protein. (243 aa)
	gata3	Trans-acting T-cell-specific transcription factor GATA-3. (441 aa)
	LOC105919467	TSC complex subunit 1. (1034 aa)
	pax5	Paired box 5. (391 aa)
	tsc2	TSC complex subunit 2. (1700 aa)
	ENSFHEP00000009082	Uncharacterized protein. (168 aa)
	cep290	Centrosomal protein 290. (2429 aa)
	LOC105929235	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (334 aa)
	LOC105917680	Vang-like protein. (525 aa)
	ENSFHEP00000009699	Uncharacterized protein. (209 aa)
	PAX2	Paired box 2b. (338 aa)
	tcap	Titin-cap (telethonin). (179 aa)
	glmn	Glomulin, FKBP associated protein a. (611 aa)
	LOC105927446	TSC complex subunit 1b. (1254 aa)
	bbs4	Bardet-Biedl syndrome 4. (544 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1075 aa)
	ENSFHEP00000013692	Phosphatase and actin regulator. (133 aa)
	ENSFHEP00000013800	Gremlin 1a, DAN family BMP antagonist. (181 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	LOC105917512	Phosphatase and actin regulator. (882 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	hs2st1	Heparan sulfate 2-O-sulfotransferase 1a. (359 aa)
	dvl3	Dishevelled segment polarity protein 3a. (668 aa)
	scrib	Scribble planar cell polarity protein. (1730 aa)
	dlx3	Distal-less homeobox 3b. (281 aa)
	bmp2	Bone morphogenetic protein 2b. (419 aa)
	LOC105921518	Lysine (K)-specific demethylase 6A, like. (1475 aa)
	ENSFHEP00000019104	Uncharacterized protein. (105 aa)
	mks1	MKS transition zone complex subunit 1. (506 aa)
	dvl1	Dishevelled segment polarity protein 1a. (718 aa)
	ENSFHEP00000019326	Coiled-coil domain containing 88C. (1157 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC105917348	Uncharacterized protein; Belongs to the MAGUK family. (538 aa)
	chrd	Chordin; Belongs to the chordin family. (1031 aa)
	wnt8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	pax2	Paired box 2a. (391 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (974 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (681 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	mpp5	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (650 aa)
	VANGL2	Vang-like protein. (525 aa)
	LOC105926495	Heparan sulfate 2-O-sulfotransferase 1b. (357 aa)
	LOC105927709	Cordon-bleu WH2 repeat protein. (1020 aa)
	LOC105927718	Iroquois homeobox 1a. (497 aa)
	LOC105926542	Bromo domain-containing protein. (1492 aa)
	LOC105919484	Mothers against decapentaplegic homolog. (412 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	deaf1	DEAF1 transcription factor. (558 aa)
	tctn3	DUF1619 domain-containing protein. (602 aa)
	ENSFHEP00000027038	Uncharacterized protein. (362 aa)
	ENSFHEP00000028686	Uncharacterized protein. (448 aa)
	LOC105920490	Homeobox domain-containing protein. (170 aa)
	LOC105935432	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (153 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1039 aa)
	LOC105932051	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	podxl	Podocalyxin. (449 aa)
	ccdc85b	Coiled-coil domain containing 85B. (200 aa)
	ENSFHEP00000030437	Paired domain-containing protein. (153 aa)
	dlx6	Distal-less homeobox 6a. (246 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2581 aa)
	ift52	Intraflagellar transport 52 homolog (Chlamydomonas). (434 aa)
	LOC105931948	Homeobox domain-containing protein. (440 aa)
	pax8	Paired box 8. (387 aa)
	abl1	Tyrosine-protein kinase. (1105 aa)
	ENSFHEP00000032666	Uncharacterized protein. (64 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heart and neural crest derivatives expressed 2.	0.491
ENSFHEP00000000835	LOC105933078	ENSFHEP00000000835	ENSFHEP00000019375	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.512
ENSFHEP00000000835	chrd	ENSFHEP00000000835	ENSFHEP00000019696	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Chordin; Belongs to the chordin family.	0.525
ENSFHEP00000000835	dlx3	ENSFHEP00000000835	ENSFHEP00000017641	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 3b.	0.424
ENSFHEP00000000835	dlx5	ENSFHEP00000000835	ENSFHEP00000014533	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 5a.	0.420
ENSFHEP00000000835	fgf3	ENSFHEP00000000835	ENSFHEP00000033502	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.844
ENSFHEP00000000835	fst	ENSFHEP00000000835	ENSFHEP00000004871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin a.	0.448
ENSFHEP00000000835	pax2	ENSFHEP00000000835	ENSFHEP00000020115	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 2a.	0.477
ENSFHEP00000000835	ret	ENSFHEP00000000835	ENSFHEP00000029667	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.807
ENSFHEP00000003392	ENSFHEP00000000835	ENSFHEP00000003392	ENSFHEP00000000835	Heart and neural crest derivatives expressed 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
ENSFHEP00000003392	dlx5	ENSFHEP00000003392	ENSFHEP00000014533	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 5a.	0.424
ENSFHEP00000003392	dlx6	ENSFHEP00000003392	ENSFHEP00000030677	Heart and neural crest derivatives expressed 2.	Distal-less homeobox 6a.	0.426
ENSFHEP00000003392	gata3	ENSFHEP00000003392	ENSFHEP00000007630	Heart and neural crest derivatives expressed 2.	Trans-acting T-cell-specific transcription factor GATA-3.	0.452
ENSFHEP00000007623	LOC105917348	ENSFHEP00000007623	ENSFHEP00000019674	Uncharacterized protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.432
ENSFHEP00000007623	LOC105917680	ENSFHEP00000007623	ENSFHEP00000009517	Uncharacterized protein.	Vang-like protein.	0.663
ENSFHEP00000007623	PTK7	ENSFHEP00000007623	ENSFHEP00000013652	Uncharacterized protein.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.501
ENSFHEP00000007623	VANGL2	ENSFHEP00000007623	ENSFHEP00000023454	Uncharacterized protein.	Vang-like protein.	0.663
ENSFHEP00000007623	mpp5	ENSFHEP00000007623	ENSFHEP00000022897	Uncharacterized protein.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.432
ENSFHEP00000009082	ENSFHEP00000027038	ENSFHEP00000009082	ENSFHEP00000027038	Uncharacterized protein.	Uncharacterized protein.	0.777
ENSFHEP00000009699	mthfd1l	ENSFHEP00000009699	ENSFHEP00000021307	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.740