(14 nodes) Epithelial cell-cell adhesion network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tie1	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1138 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	LOC105923947	Uncharacterized protein. (353 aa)
	LOC105936874	Vinculin a. (1126 aa)
	ctnna2	Catenin (cadherin-associated protein), alpha 2. (896 aa)
	CYP1C1	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (529 aa)
	cldn7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	srf	Serum response factor b. (599 aa)
	LOC105926237	Pleckstrin homology domain containing, family A member 7a. (1306 aa)
	LOC105916280	Pleckstrin homology domain containing, family A member 7b. (1275 aa)
	LOC105926177	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (546 aa)
	ctnna1	Catenin (cadherin-associated protein), alpha 1. (907 aa)
	ENSFHEP00000026175	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	LOC105928223	Vinculin b. (1066 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105924010	srf	ENSFHEP00000004618	ENSFHEP00000013718	Uncharacterized protein.	Serum response factor b.	0.933
LOC105928223	LOC105936874	ENSFHEP00000027510	ENSFHEP00000006685	Vinculin b.	Vinculin a.	0.940
LOC105928223	ctnna1	ENSFHEP00000027510	ENSFHEP00000025516	Vinculin b.	Catenin (cadherin-associated protein), alpha 1.	0.988
LOC105928223	ctnna2	ENSFHEP00000027510	ENSFHEP00000006767	Vinculin b.	Catenin (cadherin-associated protein), alpha 2.	0.986
LOC105936874	LOC105928223	ENSFHEP00000006685	ENSFHEP00000027510	Vinculin a.	Vinculin b.	0.940
LOC105936874	ctnna1	ENSFHEP00000006685	ENSFHEP00000025516	Vinculin a.	Catenin (cadherin-associated protein), alpha 1.	0.983
LOC105936874	ctnna2	ENSFHEP00000006685	ENSFHEP00000006767	Vinculin a.	Catenin (cadherin-associated protein), alpha 2.	0.985
ctnna1	LOC105928223	ENSFHEP00000025516	ENSFHEP00000027510	Catenin (cadherin-associated protein), alpha 1.	Vinculin b.	0.988
ctnna1	LOC105936874	ENSFHEP00000025516	ENSFHEP00000006685	Catenin (cadherin-associated protein), alpha 1.	Vinculin a.	0.983
ctnna1	ctnna2	ENSFHEP00000025516	ENSFHEP00000006767	Catenin (cadherin-associated protein), alpha 1.	Catenin (cadherin-associated protein), alpha 2.	0.943
ctnna2	LOC105928223	ENSFHEP00000006767	ENSFHEP00000027510	Catenin (cadherin-associated protein), alpha 2.	Vinculin b.	0.986
ctnna2	LOC105936874	ENSFHEP00000006767	ENSFHEP00000006685	Catenin (cadherin-associated protein), alpha 2.	Vinculin a.	0.985
ctnna2	ctnna1	ENSFHEP00000006767	ENSFHEP00000025516	Catenin (cadherin-associated protein), alpha 2.	Catenin (cadherin-associated protein), alpha 1.	0.943
srf	LOC105924010	ENSFHEP00000013718	ENSFHEP00000004618	Serum response factor b.	Uncharacterized protein.	0.933