(95 nodes) Regulation of muscle system process network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105927271	Alpha-2A adrenergic receptor. (399 aa)
	LOC105915710	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (504 aa)
	ENSFHEP00000017780	Kelch repeat and BTB (POZ) domain containing 13. (467 aa)
	mtpn	Uncharacterized protein. (50 aa)
	tbxa2r	Thromboxane A2 receptor. (375 aa)
	LOC105938259	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (434 aa)
	LOC105928077	Troponin T type 2b (cardiac). (248 aa)
	LOC105922967	Insulin-like growth factor binding protein 5a. (249 aa)
	LOC105928078	Troponin I type 1b (skeletal, slow). (189 aa)
	LOC105916876	Tachykinin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (416 aa)
	ctdp1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1. (1031 aa)
	srf	Serum response factor b. (599 aa)
	LOC105935457	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
	ENSFHEP00000012928	Adrenoceptor alpha 2C. (443 aa)
	LOC105923875	ANK_REP_REGION domain-containing protein. (187 aa)
	LOC105937849	Si:rp71-17i16.4. (172 aa)
	LOC105938942	Insulin-like growth factor binding protein 5a. (267 aa)
	LOC105920529	Mothers against decapentaplegic homolog. (520 aa)
	ENSFHEP00000011452	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (405 aa)
	GCA	Grancalcin. (278 aa)
	LOC105918962	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (624 aa)
	tacr2	Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	LOC105916514	Myostatin b. (420 aa)
	ucn	Urotensin 1. (144 aa)
	LOC105915427	Uncharacterized protein. (296 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	gsk3a	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
	LOC105916552	Uncharacterized protein. (2218 aa)
	mlip	Uncharacterized protein. (859 aa)
	LOC105927028	Kelch repeat and BTB domain-containing protein 13. (481 aa)
	anxa6	Annexin. (672 aa)
	LOC105920712	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (418 aa)
	LOC105936765	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	nkx2-5	NK2 homeobox 5. (313 aa)
	LOC105920780	Troponin T type 1 (skeletal, slow). (325 aa)
	LOC105938514	Troponin I4a. (256 aa)
	LOC105938517	Troponin I4b, tandem duplicate 2. (186 aa)
	LOC105931131	Zgc:171965; Belongs to the G-protein coupled receptor 1 family. (441 aa)
	pde9a	Phosphodiesterase 9A like; Belongs to the cyclic nucleotide phosphodiesterase family. (486 aa)
	LOC105925448	Cardiomyopathy associated 5. (1648 aa)
	tnni1	Troponin I type 1a (skeletal, slow). (170 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	igf1	Insulin growth factor I-like protein. (185 aa)
	RNF207	Ring finger protein 207. (631 aa)
	LOC105932975	Ankyrin repeat domain 66. (168 aa)
	TNNC1	Troponin C type 1a (slow). (180 aa)
	TNNT1	Troponin T1, slow skeletal type. (260 aa)
	EIF4EBP3	Eukaryotic translation initiation factor 4E binding protein 3, like. (114 aa)
	ADRA2C	Adrenoceptor alpha 2C. (407 aa)
	LOC105935773	ANK_REP_REGION domain-containing protein. (900 aa)
	LOC105921986	Si:dkey-206d17.12. (588 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (618 aa)
	dock4	Dedicator of cytokinesis 4b; Belongs to the DOCK family. (1969 aa)
	LOC105915366	Tachykinin receptor 1a; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	parp2	Poly [ADP-ribose] polymerase. (675 aa)
	LOC105921341	MH2 domain-containing protein. (222 aa)
	ENSFHEP00000034755	MH1 domain-containing protein. (154 aa)
	LOC105915629	Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	mymk	Myomaker, myoblast fusion factor. (235 aa)
	myog	Myogenin. (250 aa)
	LOC105930774	Mothers against decapentaplegic homolog. (393 aa)
	ENSFHEP00000032421	Spexin hormone. (179 aa)
	pkd2	Polycystic kidney disease 2. (890 aa)
	gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (380 aa)
	LOC105930303	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (507 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (425 aa)
	ankrd28	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A. (1051 aa)
	sri	Uncharacterized protein. (210 aa)
	LOC105923645	Endothelin 1. (218 aa)
	ENSFHEP00000029378	NMU domain-containing protein. (158 aa)
	tnfrsf1a	Tumor necrosis factor receptor superfamily, member 1a. (385 aa)
	tomm70	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). (578 aa)
	zdhhc21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	ENSFHEP00000026556	Uncharacterized protein. (135 aa)
	LOC105927076	Troponin T type 3a (skeletal, fast). (263 aa)
	LOC105920118	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (436 aa)
	LOC105920093	Troponin C type 1b (slow). (161 aa)
	LOC105938516	Troponin I4b, tandem duplicate 2. (179 aa)
	LOC105938515	Uncharacterized protein. (183 aa)
	LOC105938512	Uncharacterized protein. (240 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	ENSFHEP00000024528	GTF2I repeat domain containing 1. (832 aa)
	LOC105920803	LIM and cysteine-rich domains 1. (355 aa)
	KBTBD13	Kelch repeat and BTB domain containing 13. (455 aa)
	ENSFHEP00000024261	Troponin T type 2a (cardiac). (249 aa)
	LOC105933906	Endothelin 2. (161 aa)
	ENSFHEP00000022976	Troponin T2c, cardiac. (236 aa)
	pln	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (53 aa)
	ENSFHEP00000022273	Uncharacterized protein; Belongs to the potassium channel family. (590 aa)
	LOC105917287	Junction plakoglobin a. (722 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (422 aa)
	LOC105939294	Tumor necrosis factor receptor superfamily, member 1B. (454 aa)
	ENSFHEP00000019671	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (184 aa)
	pawr	PRKC apoptosis WT1 regulator protein. (337 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2C	LOC105923645	ENSFHEP00000001133	ENSFHEP00000029605	Adrenoceptor alpha 2C.	Endothelin 1.	0.582
ENSFHEP00000011452	nkx2-5	ENSFHEP00000011452	ENSFHEP00000006401	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.431
ENSFHEP00000012928	LOC105923645	ENSFHEP00000012928	ENSFHEP00000029605	Adrenoceptor alpha 2C.	Endothelin 1.	0.582
ENSFHEP00000019671	LOC105917287	ENSFHEP00000019671	ENSFHEP00000021792	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Junction plakoglobin a.	0.501
ENSFHEP00000019671	LOC105920118	ENSFHEP00000019671	ENSFHEP00000025674	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.401
ENSFHEP00000019671	cav3	ENSFHEP00000019671	ENSFHEP00000024588	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.961
ENSFHEP00000019671	gsk3a	ENSFHEP00000019671	ENSFHEP00000008832	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily.	0.401
ENSFHEP00000019671	gsk3b	ENSFHEP00000019671	ENSFHEP00000031022	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily.	0.401
ENSFHEP00000022273	LOC105918962	ENSFHEP00000022273	ENSFHEP00000010295	Uncharacterized protein; Belongs to the potassium channel family.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.909
ENSFHEP00000022273	dock4	ENSFHEP00000022273	ENSFHEP00000000052	Uncharacterized protein; Belongs to the potassium channel family.	Dedicator of cytokinesis 4b; Belongs to the DOCK family.	0.564
ENSFHEP00000022976	ENSFHEP00000024261	ENSFHEP00000022976	ENSFHEP00000024261	Troponin T2c, cardiac.	Troponin T type 2a (cardiac).	0.816
ENSFHEP00000022976	ENSFHEP00000026556	ENSFHEP00000022976	ENSFHEP00000026556	Troponin T2c, cardiac.	Uncharacterized protein.	0.738
ENSFHEP00000022976	LOC105920093	ENSFHEP00000022976	ENSFHEP00000025637	Troponin T2c, cardiac.	Troponin C type 1b (slow).	0.885
ENSFHEP00000022976	LOC105928077	ENSFHEP00000022976	ENSFHEP00000015741	Troponin T2c, cardiac.	Troponin T type 2b (cardiac).	0.815
ENSFHEP00000022976	LOC105928078	ENSFHEP00000022976	ENSFHEP00000015716	Troponin T2c, cardiac.	Troponin I type 1b (skeletal, slow).	0.916
ENSFHEP00000022976	LOC105937849	ENSFHEP00000022976	ENSFHEP00000012399	Troponin T2c, cardiac.	Si:rp71-17i16.4.	0.863
ENSFHEP00000022976	LOC105938512	ENSFHEP00000022976	ENSFHEP00000024627	Troponin T2c, cardiac.	Uncharacterized protein.	0.741
ENSFHEP00000022976	LOC105938514	ENSFHEP00000022976	ENSFHEP00000005457	Troponin T2c, cardiac.	Troponin I4a.	0.858
ENSFHEP00000022976	LOC105938515	ENSFHEP00000022976	ENSFHEP00000024665	Troponin T2c, cardiac.	Uncharacterized protein.	0.858
ENSFHEP00000022976	LOC105938516	ENSFHEP00000022976	ENSFHEP00000024683	Troponin T2c, cardiac.	Troponin I4b, tandem duplicate 2.	0.858