(56 nodes) Cellular response to alcohol network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC105922049	Prostaglandin E receptor 2a (subtype EP2). (371 aa)
	LOC105929512	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1189 aa)
	ptgfr	Prostaglandin F receptor (FP). (364 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (564 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (649 aa)
	LOC105927766	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	ENSFHEP00000001801	Bloom syndrome, RecQ helicase. (1405 aa)
	LOC105918984	Uncharacterized protein. (354 aa)
	LOC105924112	Uncharacterized protein. (185 aa)
	LOC105935293	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1439 aa)
	ENSFHEP00000005790	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (370 aa)
	LOC105935576	Uncharacterized protein. (354 aa)
	rad51	RAD51 recombinase; Belongs to the RecA family. (142 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	CYP1C1	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (529 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1072 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1503 aa)
	adcy8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1214 aa)
	mlc1	Modulator of VRAC current 1. (376 aa)
	ENSFHEP00000011014	Golgi phosphoprotein 3. (100 aa)
	SPIDR	Scaffold protein involved in DNA repair. (790 aa)
	podn	Podocan. (587 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
	LOC105935238	Adenylate cyclase 1b. (941 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1207 aa)
	LOC105917541	Orthodenticle homeobox 2b. (296 aa)
	ENSFHEP00000015614	XRN_N domain-containing protein. (103 aa)
	ENSFHEP00000015621	Uncharacterized protein. (457 aa)
	ENSFHEP00000015847	Glycine receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	ENSFHEP00000017372	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (397 aa)
	recql5	RecQ helicase-like 5. (1014 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (812 aa)
	LOC105926177	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (546 aa)
	gramd1a	GRAM domain containing 1A. (647 aa)
	golph3	Si:dkey-27b3.2. (294 aa)
	LOC105928969	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1178 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	LOC105917287	Junction plakoglobin a. (722 aa)
	LOC105928759	Prostaglandin E receptor 4 (subtype EP4) b. (460 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	LOC105933857	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (481 aa)
	ENSFHEP00000024666	COesterase domain-containing protein. (163 aa)
	LOC105932885	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1128 aa)
	ENSFHEP00000026175	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	brca1	Breast cancer 1, early onset. (1357 aa)
	LOC105920622	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	LOC105921138	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (424 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (286 aa)
	ENSFHEP00000030023	COesterase domain-containing protein. (275 aa)
	ENSFHEP00000030190	Uncharacterized protein. (81 aa)
	gramd1b	GRAM domain containing 1Bb. (725 aa)
	ENSFHEP00000030439	Uncharacterized protein. (151 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1130 aa)
	gramd1c	GRAM domain containing 1c. (660 aa)
	glra2	Glycine receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP1C1	brca1	ENSFHEP00000007715	ENSFHEP00000026695	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.	Breast cancer 1, early onset.	0.488
ENSFHEP00000001801	ENSFHEP00000030190	ENSFHEP00000001801	ENSFHEP00000030190	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.972
ENSFHEP00000001801	SPIDR	ENSFHEP00000001801	ENSFHEP00000011358	Bloom syndrome, RecQ helicase.	Scaffold protein involved in DNA repair.	0.704
ENSFHEP00000001801	brca1	ENSFHEP00000001801	ENSFHEP00000026695	Bloom syndrome, RecQ helicase.	Breast cancer 1, early onset.	0.926
ENSFHEP00000001801	rad51	ENSFHEP00000001801	ENSFHEP00000007370	Bloom syndrome, RecQ helicase.	RAD51 recombinase; Belongs to the RecA family.	0.972
ENSFHEP00000001801	recql5	ENSFHEP00000001801	ENSFHEP00000017727	Bloom syndrome, RecQ helicase.	RecQ helicase-like 5.	0.765
ENSFHEP00000005790	LOC105918984	ENSFHEP00000005790	ENSFHEP00000002296	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.925
ENSFHEP00000005790	LOC105928969	ENSFHEP00000005790	ENSFHEP00000021010	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.608
ENSFHEP00000005790	LOC105929512	ENSFHEP00000005790	ENSFHEP00000000409	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.702
ENSFHEP00000005790	LOC105932885	ENSFHEP00000005790	ENSFHEP00000024680	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.682
ENSFHEP00000005790	LOC105935238	ENSFHEP00000005790	ENSFHEP00000013703	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 1b.	0.685
ENSFHEP00000005790	LOC105935576	ENSFHEP00000005790	ENSFHEP00000006487	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.927
ENSFHEP00000005790	adcy5	ENSFHEP00000005790	ENSFHEP00000030613	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.605
ENSFHEP00000005790	adcy6	ENSFHEP00000005790	ENSFHEP00000013789	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.607
ENSFHEP00000005790	adcy8	ENSFHEP00000005790	ENSFHEP00000010646	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.697
ENSFHEP00000011014	LOC105924112	ENSFHEP00000011014	ENSFHEP00000003637	Golgi phosphoprotein 3.	Uncharacterized protein.	0.919
ENSFHEP00000015614	ENSFHEP00000015621	ENSFHEP00000015614	ENSFHEP00000015621	XRN_N domain-containing protein.	Uncharacterized protein.	0.949
ENSFHEP00000015614	rad51	ENSFHEP00000015614	ENSFHEP00000007370	XRN_N domain-containing protein.	RAD51 recombinase; Belongs to the RecA family.	0.494
ENSFHEP00000015621	ENSFHEP00000015614	ENSFHEP00000015621	ENSFHEP00000015614	Uncharacterized protein.	XRN_N domain-containing protein.	0.949
ENSFHEP00000015621	ENSFHEP00000030190	ENSFHEP00000015621	ENSFHEP00000030190	Uncharacterized protein.	Uncharacterized protein.	0.431