(23 nodes) Cellular response to virus network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (390 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (618 aa)
	LOC105921986	Si:dkey-206d17.12. (588 aa)
	LOC105921960	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (752 aa)
	LOC105926671	Interferon regulatory factor 3. (465 aa)
	WDFY4	WDFY family member 4. (2575 aa)
	pou2af1	Uncharacterized protein. (299 aa)
	bax	Uncharacterized protein. (240 aa)
	ENSFHEP00000005380	Uncharacterized protein. (74 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	ENSFHEP00000012256	Gasdermin domain-containing protein. (140 aa)
	gsdme	Gasdermin Eb. (468 aa)
	sting1	Stimulator of interferon genes protein. (400 aa)
	adar	Adenosine deaminase RNA specific. (1356 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC105922142	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (724 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (544 aa)
	tomm70	Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae). (578 aa)
	LOC105928170	SCY domain-containing protein. (110 aa)
	phb	Prohibitin. (271 aa)
	LOC105929715	LSM14A mRNA processing body assembly factor a. (486 aa)
	LOC105919714	LSM14A mRNA processing body assembly factor b. (440 aa)
	ifih1	Interferon induced with helicase C domain 1. (973 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	phb	ENSFHEP00000002138	ENSFHEP00000028873	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Prohibitin.	0.512
LOC105921960	LOC105922142	ENSFHEP00000000519	ENSFHEP00000020342	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.927
LOC105922142	LOC105921960	ENSFHEP00000020342	ENSFHEP00000000519	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.927
LOC105926671	bax	ENSFHEP00000002063	ENSFHEP00000004805	Interferon regulatory factor 3.	Uncharacterized protein.	0.570
LOC105926671	dhx58	ENSFHEP00000002063	ENSFHEP00000010836	Interferon regulatory factor 3.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.735
LOC105926671	ifih1	ENSFHEP00000002063	ENSFHEP00000034810	Interferon regulatory factor 3.	Interferon induced with helicase C domain 1.	0.771
LOC105926671	sting1	ENSFHEP00000002063	ENSFHEP00000014549	Interferon regulatory factor 3.	Stimulator of interferon genes protein.	0.988
WDFY4	dhx58	ENSFHEP00000003730	ENSFHEP00000010836	WDFY family member 4.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.524
WDFY4	ifih1	ENSFHEP00000003730	ENSFHEP00000034810	WDFY family member 4.	Interferon induced with helicase C domain 1.	0.524
adar	dhx58	ENSFHEP00000019192	ENSFHEP00000010836	Adenosine deaminase RNA specific.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.425
adar	ifih1	ENSFHEP00000019192	ENSFHEP00000034810	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.577
bax	LOC105926671	ENSFHEP00000004805	ENSFHEP00000002063	Uncharacterized protein.	Interferon regulatory factor 3.	0.570
dhx58	LOC105926671	ENSFHEP00000010836	ENSFHEP00000002063	DEXH (Asp-Glu-X-His) box polypeptide 58.	Interferon regulatory factor 3.	0.735
dhx58	WDFY4	ENSFHEP00000010836	ENSFHEP00000003730	DEXH (Asp-Glu-X-His) box polypeptide 58.	WDFY family member 4.	0.524
dhx58	adar	ENSFHEP00000010836	ENSFHEP00000019192	DEXH (Asp-Glu-X-His) box polypeptide 58.	Adenosine deaminase RNA specific.	0.425
dhx58	ifih1	ENSFHEP00000010836	ENSFHEP00000034810	DEXH (Asp-Glu-X-His) box polypeptide 58.	Interferon induced with helicase C domain 1.	0.991
dhx58	sting1	ENSFHEP00000010836	ENSFHEP00000014549	DEXH (Asp-Glu-X-His) box polypeptide 58.	Stimulator of interferon genes protein.	0.444
ifih1	LOC105926671	ENSFHEP00000034810	ENSFHEP00000002063	Interferon induced with helicase C domain 1.	Interferon regulatory factor 3.	0.771
ifih1	WDFY4	ENSFHEP00000034810	ENSFHEP00000003730	Interferon induced with helicase C domain 1.	WDFY family member 4.	0.524
ifih1	adar	ENSFHEP00000034810	ENSFHEP00000019192	Interferon induced with helicase C domain 1.	Adenosine deaminase RNA specific.	0.577