(72 nodes) Regulation of protein localization to nucleus network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105931314	Leucine zipper, putative tumor suppressor family member 3b. (715 aa)
	flcn	Folliculin. (564 aa)
	ENSFHEP00000030519	RING-type domain-containing protein. (179 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC105921194	Neurofibromin 2a (merlin). (369 aa)
	nvl	Nuclear VCP like. (842 aa)
	glis2	GLIS family zinc finger 2b. (486 aa)
	LOC105920050	Apolipoprotein Da, duplicate 1; Belongs to the calycin superfamily. Lipocalin family. (187 aa)
	mcrs1	Microspherule protein 1. (455 aa)
	ENSFHEP00000025475	WW domain-containing protein. (184 aa)
	polr1a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1605 aa)
	nolc1	Nucleolar and coiled-body phosphoprotein 1. (1004 aa)
	ENSFHEP00000023942	CARD domain-containing protein. (171 aa)
	chp1	Calcineurin-like EF-hand protein 1. (187 aa)
	LOC105916734	Testis associated actin remodelling kinase 2. (632 aa)
	LOC105938715	RING-type domain-containing protein. (602 aa)
	ENSFHEP00000022657	ZPR1 zinc finger. (193 aa)
	nf1	Neurofibromin 1b. (2547 aa)
	LOC105917287	Junction plakoglobin a. (722 aa)
	LOC105937498	Nerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
	rab23	RAB23, member RAS oncogene family. (235 aa)
	LOC105928998	RING-type domain-containing protein. (192 aa)
	ENSFHEP00000020106	DTC domain-containing protein. (522 aa)
	ENSFHEP00000019580	Phorbol-ester/DAG-type domain-containing protein. (324 aa)
	ENSFHEP00000019438	Uncharacterized protein. (428 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (812 aa)
	fermt1	Fermitin family member 1. (665 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2535 aa)
	fbxo4	F-box protein 4. (390 aa)
	lats1	Large tumor suppressor kinase 1. (1065 aa)
	ect2	Epithelial cell transforming 2. (888 aa)
	pkig	Protein kinase (cAMP-dependent, catalytic) inhibitor gamma. (106 aa)
	lats2	Serine/threonine-protein kinase LATS2. (1152 aa)
	LOC105919906	7SK snRNA methylphosphate capping enzyme. (722 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (1513 aa)
	atp13a2	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1165 aa)
	LOC105915343	Calcineurin-like EF-hand protein 2. (194 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (381 aa)
	LOC105918804	Si:dkeyp-75h12.2. (685 aa)
	ENSFHEP00000009660	Leucine zipper, putative tumor suppressor 2b. (323 aa)
	LOC105937985	Doublecortin-like kinase 1b. (745 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1136 aa)
	LOC105923832	RING-type domain-containing protein. (651 aa)
	ENSFHEP00000006808	Uncharacterized protein. (159 aa)
	dmap1	DNA methyltransferase 1-associated protein 1. (486 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (515 aa)
	f2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (620 aa)
	ENSFHEP00000004332	Guanylate kinase-like domain-containing protein. (244 aa)
	LOC105917873	Neurofibromin 2b (merlin). (591 aa)
	nup58	Nucleoporin 58. (596 aa)
	nup54	Nucleoporin p54. (566 aa)
	LOC105935727	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
	LOC105935755	Apolipoprotein Db; Belongs to the calycin superfamily. Lipocalin family. (193 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (436 aa)
	sirt6	Sirtuin 6. (352 aa)
	mfhas1	Malignant fibrous histiocytoma-amplified sequence 1. (1028 aa)
	efcab7	EF-hand calcium binding domain 7. (614 aa)
	LOC105940305	Translocated promoter region a, nuclear basket protein. (2150 aa)
	dclk1	Doublecortin-like kinase 1a. (697 aa)
	LOC105921986	Si:dkey-206d17.12. (588 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (618 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (316 aa)
	ipo5	Karyopherin (importin) beta 3. (1094 aa)
	LOC105928986	Zgc:66440. (397 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (378 aa)
	LOC105939479	GLIS family zinc finger 2. (496 aa)
	ENSFHEP00000033951	Uncharacterized protein. (293 aa)
	RASSF5	Ras association domain family member 5. (245 aa)
	larp7	La ribonucleoprotein domain family, member 7. (563 aa)
	ENSFHEP00000034358	RING-type domain-containing protein. (201 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000004332	ENSFHEP00000023942	ENSFHEP00000004332	ENSFHEP00000023942	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.857
ENSFHEP00000019438	ENSFHEP00000033951	ENSFHEP00000019438	ENSFHEP00000033951	Uncharacterized protein.	Uncharacterized protein.	0.939
ENSFHEP00000019438	LOC105940305	ENSFHEP00000019438	ENSFHEP00000000653	Uncharacterized protein.	Translocated promoter region a, nuclear basket protein.	0.891
ENSFHEP00000019438	nup54	ENSFHEP00000019438	ENSFHEP00000002468	Uncharacterized protein.	Nucleoporin p54.	0.772
ENSFHEP00000019438	nup58	ENSFHEP00000019438	ENSFHEP00000003139	Uncharacterized protein.	Nucleoporin 58.	0.711
ENSFHEP00000019438	tpr	ENSFHEP00000019438	ENSFHEP00000012785	Uncharacterized protein.	Translocated promoter region b, nuclear basket protein.	0.940
ENSFHEP00000019580	RASSF5	ENSFHEP00000019580	ENSFHEP00000034029	Phorbol-ester/DAG-type domain-containing protein.	Ras association domain family member 5.	0.881
ENSFHEP00000020106	ENSFHEP00000030519	ENSFHEP00000020106	ENSFHEP00000030519	DTC domain-containing protein.	RING-type domain-containing protein.	0.463
ENSFHEP00000020106	ENSFHEP00000034358	ENSFHEP00000020106	ENSFHEP00000034358	DTC domain-containing protein.	RING-type domain-containing protein.	0.476
ENSFHEP00000022657	polr1a	ENSFHEP00000022657	ENSFHEP00000024388	ZPR1 zinc finger.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.762
ENSFHEP00000023942	ENSFHEP00000004332	ENSFHEP00000023942	ENSFHEP00000004332	CARD domain-containing protein.	Guanylate kinase-like domain-containing protein.	0.857
ENSFHEP00000025475	LOC105916734	ENSFHEP00000025475	ENSFHEP00000023461	WW domain-containing protein.	Testis associated actin remodelling kinase 2.	0.410
ENSFHEP00000025475	LOC105918804	ENSFHEP00000025475	ENSFHEP00000009764	WW domain-containing protein.	Si:dkeyp-75h12.2.	0.410
ENSFHEP00000025475	lats1	ENSFHEP00000025475	ENSFHEP00000014964	WW domain-containing protein.	Large tumor suppressor kinase 1.	0.719
ENSFHEP00000025475	lats2	ENSFHEP00000025475	ENSFHEP00000013786	WW domain-containing protein.	Serine/threonine-protein kinase LATS2.	0.719
ENSFHEP00000030519	ENSFHEP00000020106	ENSFHEP00000030519	ENSFHEP00000020106	RING-type domain-containing protein.	DTC domain-containing protein.	0.463
ENSFHEP00000033951	ENSFHEP00000019438	ENSFHEP00000033951	ENSFHEP00000019438	Uncharacterized protein.	Uncharacterized protein.	0.939
ENSFHEP00000033951	LOC105940305	ENSFHEP00000033951	ENSFHEP00000000653	Uncharacterized protein.	Translocated promoter region a, nuclear basket protein.	0.885
ENSFHEP00000033951	nup54	ENSFHEP00000033951	ENSFHEP00000002468	Uncharacterized protein.	Nucleoporin p54.	0.772
ENSFHEP00000033951	nup58	ENSFHEP00000033951	ENSFHEP00000003139	Uncharacterized protein.	Nucleoporin 58.	0.711