(102 nodes) Regulation of leukocyte differentiation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105935283	CCAAT enhancer binding protein beta. (288 aa)
	xbp1	X-box binding protein 1. (312 aa)
	bad	BCL2 associated agonist of cell death b. (209 aa)
	ENSFHEP00000023349	Suppressor of cytokine signaling 1a. (205 aa)
	LOC105926065	Colony stimulating factor 1b (macrophage). (299 aa)
	LOC105936849	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (823 aa)
	pglyrp2	Uncharacterized protein. (482 aa)
	LOC105935791	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (269 aa)
	LOC105937422	Uncharacterized protein. (258 aa)
	dusp10	Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	LOC105929577	Uncharacterized protein. (787 aa)
	LOC105939874	PRELI domain-containing protein 1, mitochondrial. (212 aa)
	il10	Interleukin 10. (268 aa)
	fstl3	Follistatin-like 3 (secreted glycoprotein). (150 aa)
	LOC105933078	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	ppp2r3c	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (457 aa)
	tfe3	Transcription factor binding to IGHM enhancer 3b. (457 aa)
	tcf7	Transcription factor 7. (422 aa)
	ENSFHEP00000017807	Uncharacterized protein. (517 aa)
	LOC105938255	Complement C1q C chain. (240 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (769 aa)
	LOC105930243	Uncharacterized protein; Belongs to the peptidase C14A family. (499 aa)
	LOC105938266	Immunoglobulin superfamily, member 3. (1059 aa)
	LOC105934402	Melanocyte inducing transcription factor a. (417 aa)
	LOC105919260	Transcription factor E3. (493 aa)
	ENSFHEP00000015842	SAP domain-containing protein. (1130 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (578 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (576 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B. (416 aa)
	ENSFHEP00000014652	Transmembrane protein 178. (280 aa)
	syk	Tyrosine-protein kinase. (621 aa)
	LOC105915293	Tescalcin b. (238 aa)
	nfkbid	ANK_REP_REGION domain-containing protein. (403 aa)
	LOC105937891	Interferon regulatory factor. (295 aa)
	LOC105931538	Uncharacterized protein. (461 aa)
	slc46a2	Solute carrier family 46 member 2. (445 aa)
	kat2a	K(lysine) acetyltransferase 2A. (729 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	hax1	HCLS1 associated protein X-1. (299 aa)
	crtam	Uncharacterized protein. (353 aa)
	card11	Caspase recruitment domain-containing protein 11. (1152 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (773 aa)
	gas6	Uncharacterized protein. (650 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (477 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1085 aa)
	FANCA	FA complementation group A. (990 aa)
	gata3	Trans-acting T-cell-specific transcription factor GATA-3. (441 aa)
	LOC105932162	NACHT, LRR and PYD domains-containing protein 14. (930 aa)
	ENSFHEP00000006195	Uncharacterized protein; Belongs to the peptidase C14A family. (284 aa)
	GATA2	Endothelial transcription factor GATA-2. (460 aa)
	LOC105927108	Angiopoietin-related protein. (424 aa)
	MITF	Melanocyte inducing transcription factor b. (483 aa)
	tbx21	T-box transcription factor 21. (614 aa)
	LOC105932178	Si:dkey-175m17.7. (862 aa)
	LOC105926046	Endothelial transcription factor GATA-2. (462 aa)
	tesc	Tescalcin a. (233 aa)
	malt1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (830 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)
	drosha	Drosha ribonuclease III. (1183 aa)
	LOC105932356	MALT paracaspase 3. (653 aa)
	rb1	Retinoblastoma-associated protein. (913 aa)
	tmem131l	Transmembrane 131 like. (1512 aa)
	LOC105929581	Si:ch211-203k16.3. (346 aa)
	LOC105921986	Si:dkey-206d17.12. (588 aa)
	zc3h12a	Zinc finger CCCH-type containing 12A. (618 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (394 aa)
	ptprc	Uncharacterized protein. (989 aa)
	LOC105939312	Tyrosine-protein kinase. (606 aa)
	ENSFHEP00000033938	TB domain-containing protein. (111 aa)
	fadd	Uncharacterized protein. (195 aa)
	foxn1	Forkhead box N1. (486 aa)
	LOC105917391	PR domain containing 1b, with ZNF domain. (623 aa)
	vsir	V-set immunoregulatory receptor. (295 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1168 aa)
	LOC105938267	Uncharacterized protein. (986 aa)
	ENSFHEP00000032115	Ig-like domain-containing protein. (319 aa)
	il34	Interleukin 34. (225 aa)
	cbfb	Core-binding factor subunit beta. (174 aa)
	ENSFHEP00000031539	Apoptotic chromatin condensation inducer 1a. (573 aa)
	sash3	SAM and SH3 domain containing 3. (399 aa)
	LOC105922347	Son of sevenless homolog 1 (Drosophila). (1175 aa)
	ENSFHEP00000030656	KRAP_IP3R_bind domain-containing protein. (492 aa)
	cd83	Ig-like domain-containing protein. (242 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (927 aa)
	sh3rf1	SH3 domain containing ring finger 1. (852 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (268 aa)
	tmem64	Transmembrane protein 64. (349 aa)
	LOC105928170	SCY domain-containing protein. (110 aa)
	rc3h2	Ring finger and CCCH-type domains 2. (1122 aa)
	ENSFHEP00000028182	Bromo domain-containing protein. (84 aa)
	cd28	CD28 molecule. (243 aa)
	prelid1	PRELI domain containing 1a. (210 aa)
	LOC105936652	PR domain containing 1a, with ZNF domain. (837 aa)
	fgl2	Fibrinogen-like 2a. (502 aa)
	ctnnbip1	Catenin, beta interacting protein 1. (81 aa)
	LOC105918304	Leucine rich repeat containing 17. (445 aa)
	myb	V-myb avian myeloblastosis viral oncogene homolog. (588 aa)
	fbxo7	F-box only protein 7. (468 aa)
	lef1	Lymphoid enhancer-binding factor 1. (424 aa)
	fancd2	FA complementation group D2. (1376 aa)
	ENSFHEP00000024326	Osteoclast stimulatory transmembrane protein. (463 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCSTAMP	ENSFHEP00000024326	ENSFHEP00000008835	ENSFHEP00000024326	Dendrocyte expressed seven transmembrane protein.	Osteoclast stimulatory transmembrane protein.	0.609
DCSTAMP	LOC105935791	ENSFHEP00000008835	ENSFHEP00000021869	Dendrocyte expressed seven transmembrane protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.526
ENSFHEP00000006195	LOC105930243	ENSFHEP00000006195	ENSFHEP00000017119	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.924
ENSFHEP00000006195	LOC105932356	ENSFHEP00000006195	ENSFHEP00000001732	Uncharacterized protein; Belongs to the peptidase C14A family.	MALT paracaspase 3.	0.961
ENSFHEP00000006195	LOC105936849	ENSFHEP00000006195	ENSFHEP00000023309	Uncharacterized protein; Belongs to the peptidase C14A family.	Mucosa-associated lymphoid tissue lymphoma translocation protein 1.	0.966
ENSFHEP00000006195	LOC105937422	ENSFHEP00000006195	ENSFHEP00000021380	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.502
ENSFHEP00000006195	LOC105939312	ENSFHEP00000006195	ENSFHEP00000034292	Uncharacterized protein; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.562
ENSFHEP00000006195	card11	ENSFHEP00000006195	ENSFHEP00000009241	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase recruitment domain-containing protein 11.	0.613
ENSFHEP00000006195	fadd	ENSFHEP00000006195	ENSFHEP00000033591	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.995
ENSFHEP00000006195	malt1	ENSFHEP00000006195	ENSFHEP00000003226	Uncharacterized protein; Belongs to the peptidase C14A family.	Mucosa-associated lymphoid tissue lymphoma translocation protein 1.	0.961
ENSFHEP00000006195	ripk2	ENSFHEP00000006195	ENSFHEP00000015251	Uncharacterized protein; Belongs to the peptidase C14A family.	Receptor-interacting serine-threonine kinase 2.	0.638
ENSFHEP00000006195	syk	ENSFHEP00000006195	ENSFHEP00000013734	Uncharacterized protein; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.554
ENSFHEP00000015842	ENSFHEP00000017807	ENSFHEP00000015842	ENSFHEP00000017807	SAP domain-containing protein.	Uncharacterized protein.	0.994
ENSFHEP00000015842	ENSFHEP00000031539	ENSFHEP00000015842	ENSFHEP00000031539	SAP domain-containing protein.	Apoptotic chromatin condensation inducer 1a.	0.900
ENSFHEP00000017807	ENSFHEP00000015842	ENSFHEP00000017807	ENSFHEP00000015842	Uncharacterized protein.	SAP domain-containing protein.	0.994
ENSFHEP00000017807	ENSFHEP00000031539	ENSFHEP00000017807	ENSFHEP00000031539	Uncharacterized protein.	Apoptotic chromatin condensation inducer 1a.	0.903
ENSFHEP00000023349	LOC105937891	ENSFHEP00000023349	ENSFHEP00000011715	Suppressor of cytokine signaling 1a.	Interferon regulatory factor.	0.652
ENSFHEP00000023349	LOC105939312	ENSFHEP00000023349	ENSFHEP00000034292	Suppressor of cytokine signaling 1a.	Tyrosine-protein kinase.	0.592
ENSFHEP00000023349	il10	ENSFHEP00000023349	ENSFHEP00000019709	Suppressor of cytokine signaling 1a.	Interleukin 10.	0.530
ENSFHEP00000023349	syk	ENSFHEP00000023349	ENSFHEP00000013734	Suppressor of cytokine signaling 1a.	Tyrosine-protein kinase.	0.569