(26 nodes) Positive regulation of DNA-templated transcription, initiation network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
	TAF4	TATA-box binding protein associated factor 4. (856 aa)
	ercc6	Excision repair cross-complementation group 6. (1336 aa)
	gtf2a1	General transcription factor IIA, 1. (384 aa)
	LOC105924010	Uncharacterized protein. (323 aa)
	LOC105924004	TAF4 domain-containing protein. (210 aa)
	LOC105926037	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (842 aa)
	taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (961 aa)
	nkx2-5	NK2 homeobox 5. (313 aa)
	ercc1	Excision repair cross-complementation group 1. (366 aa)
	med14	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1268 aa)
	taf12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (161 aa)
	taf13	TATA-box binding protein associated factor 13. (125 aa)
	ENSFHEP00000013026	JunE proto-oncogene, AP-1 transcription factor subunit. (334 aa)
	srf	Serum response factor b. (599 aa)
	fosl1	FOS-like antigen 1a. (341 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1792 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1013 aa)
	sub1	PC4 domain-containing protein. (156 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (365 aa)
	taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (637 aa)
	ENSFHEP00000023935	Si:dkey-23i12.7. (176 aa)
	gtf2a2	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (142 aa)
	LOC105929708	Transcription initiation factor TFIID subunit. (929 aa)
	LOC105919702	TAFH domain-containing protein. (805 aa)
	LOC105928914	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (324 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000013026	ENSFHEP00000023935	ENSFHEP00000013026	ENSFHEP00000023935	JunE proto-oncogene, AP-1 transcription factor subunit.	Si:dkey-23i12.7.	0.912
ENSFHEP00000013026	fosl1	ENSFHEP00000013026	ENSFHEP00000013847	JunE proto-oncogene, AP-1 transcription factor subunit.	FOS-like antigen 1a.	0.912
ENSFHEP00000013026	taf12	ENSFHEP00000013026	ENSFHEP00000010567	JunE proto-oncogene, AP-1 transcription factor subunit.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.574
ENSFHEP00000023935	ENSFHEP00000013026	ENSFHEP00000023935	ENSFHEP00000013026	Si:dkey-23i12.7.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.912
ENSFHEP00000023935	LOC105919702	ENSFHEP00000023935	ENSFHEP00000034272	Si:dkey-23i12.7.	TAFH domain-containing protein.	0.416
ENSFHEP00000023935	LOC105924004	ENSFHEP00000023935	ENSFHEP00000004730	Si:dkey-23i12.7.	TAF4 domain-containing protein.	0.416
ENSFHEP00000023935	LOC105926037	ENSFHEP00000023935	ENSFHEP00000005286	Si:dkey-23i12.7.	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.416
ENSFHEP00000023935	LOC105928914	ENSFHEP00000023935	ENSFHEP00000000219	Si:dkey-23i12.7.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.912
ENSFHEP00000023935	LOC105929708	ENSFHEP00000023935	ENSFHEP00000032828	Si:dkey-23i12.7.	Transcription initiation factor TFIID subunit.	0.416
ENSFHEP00000023935	TAF4	ENSFHEP00000023935	ENSFHEP00000002580	Si:dkey-23i12.7.	TATA-box binding protein associated factor 4.	0.416
ENSFHEP00000023935	med1	ENSFHEP00000023935	ENSFHEP00000014059	Si:dkey-23i12.7.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.444
LOC105919702	ENSFHEP00000023935	ENSFHEP00000034272	ENSFHEP00000023935	TAFH domain-containing protein.	Si:dkey-23i12.7.	0.416
LOC105919702	LOC105924004	ENSFHEP00000034272	ENSFHEP00000004730	TAFH domain-containing protein.	TAF4 domain-containing protein.	0.813
LOC105919702	LOC105926037	ENSFHEP00000034272	ENSFHEP00000005286	TAFH domain-containing protein.	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.932
LOC105919702	TAF4	ENSFHEP00000034272	ENSFHEP00000002580	TAFH domain-containing protein.	TATA-box binding protein associated factor 4.	0.810
LOC105919702	fosl1	ENSFHEP00000034272	ENSFHEP00000013847	TAFH domain-containing protein.	FOS-like antigen 1a.	0.416
LOC105919702	gtf2a1	ENSFHEP00000034272	ENSFHEP00000004113	TAFH domain-containing protein.	General transcription factor IIA, 1.	0.827
LOC105919702	gtf2a2	ENSFHEP00000034272	ENSFHEP00000030585	TAFH domain-containing protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.860
LOC105919702	med1	ENSFHEP00000034272	ENSFHEP00000014059	TAFH domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.439
LOC105919702	med14	ENSFHEP00000034272	ENSFHEP00000008722	TAFH domain-containing protein.	Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.451