(32 nodes) Negative regulation of signaling receptor activity network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	LYPD1	LY6/PLAUR domain containing 1. (86 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (674 aa)
	LOC105940217	Dickkopf WNT signaling pathway inhibitor 1a. (261 aa)
	LOC105934525	Suppressor of cytokine signaling 9. (542 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (952 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (320 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	GPRC5D	G protein-coupled receptor class C group 5 member D. (420 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3a. (276 aa)
	LYPD6	LY6/PLAUR domain containing 6. (157 aa)
	zgpat	Zinc finger, CCCH-type with G patch domain. (561 aa)
	LOC110366958	Zgc:123278. (186 aa)
	cnrip1	CB1 cannabinoid receptor-interacting protein 1. (162 aa)
	LOC105919329	Dickkopf-related protein 2. (288 aa)
	wfikkn2	Info WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2a. (568 aa)
	lrpap1	Low density lipoprotein receptor-related protein associated protein 1. (347 aa)
	LOC105927358	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b. (577 aa)
	LOC105931336	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	LOC105929026	Uncharacterized protein. (732 aa)
	fam72a	Family with sequence similarity 72, member B, putative. (149 aa)
	LOC105929638	Dickkopf WNT signaling pathway inhibitor 3b. (257 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (422 aa)
	ENSFHEP00000021949	Inhibitor_Mig-6 domain-containing protein. (368 aa)
	LOC105928709	Si:ch73-380n15.2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (339 aa)
	LOC105939656	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (555 aa)
	RAMP3	Receptor activity modifying protein 3. (165 aa)
	zfyve28	Zinc finger, FYVE domain containing 28. (1006 aa)
	LOC105916502	Uncharacterized protein. (177 aa)
	LOC105918222	Tumor susceptibility 101a. (416 aa)
	LOC105919312	Cannabinoid receptor interacting protein 1a. (162 aa)
	ENSFHEP00000033530	Suppressor of cytokine signaling 5b. (617 aa)
	wfikkn1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (589 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105919329	LOC105929638	ENSFHEP00000012676	ENSFHEP00000020065	Dickkopf-related protein 2.	Dickkopf WNT signaling pathway inhibitor 3b.	0.412
LOC105919329	LOC105940217	ENSFHEP00000012676	ENSFHEP00000001212	Dickkopf-related protein 2.	Dickkopf WNT signaling pathway inhibitor 1a.	0.932
LOC105919329	dkk2	ENSFHEP00000012676	ENSFHEP00000005193	Dickkopf-related protein 2.	Dickkopf WNT signaling pathway inhibitor 2.	0.902
LOC105919329	dkk3	ENSFHEP00000012676	ENSFHEP00000005528	Dickkopf-related protein 2.	Dickkopf WNT signaling pathway inhibitor 3a.	0.412
LOC105929026	LOC105939656	ENSFHEP00000019459	ENSFHEP00000024806	Uncharacterized protein.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.949
LOC105929026	cbl	ENSFHEP00000019459	ENSFHEP00000004854	Uncharacterized protein.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.944
LOC105929638	LOC105919329	ENSFHEP00000020065	ENSFHEP00000012676	Dickkopf WNT signaling pathway inhibitor 3b.	Dickkopf-related protein 2.	0.412
LOC105929638	LOC105940217	ENSFHEP00000020065	ENSFHEP00000001212	Dickkopf WNT signaling pathway inhibitor 3b.	Dickkopf WNT signaling pathway inhibitor 1a.	0.511
LOC105929638	dkk2	ENSFHEP00000020065	ENSFHEP00000005193	Dickkopf WNT signaling pathway inhibitor 3b.	Dickkopf WNT signaling pathway inhibitor 2.	0.412
LOC105939656	LOC105929026	ENSFHEP00000024806	ENSFHEP00000019459	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	Uncharacterized protein.	0.949
LOC105939656	cbl	ENSFHEP00000024806	ENSFHEP00000004854	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	Cbl proto-oncogene, E3 ubiquitin protein ligase.	0.944
LOC105940217	LOC105919329	ENSFHEP00000001212	ENSFHEP00000012676	Dickkopf WNT signaling pathway inhibitor 1a.	Dickkopf-related protein 2.	0.932
LOC105940217	LOC105929638	ENSFHEP00000001212	ENSFHEP00000020065	Dickkopf WNT signaling pathway inhibitor 1a.	Dickkopf WNT signaling pathway inhibitor 3b.	0.511
LOC105940217	dkk2	ENSFHEP00000001212	ENSFHEP00000005193	Dickkopf WNT signaling pathway inhibitor 1a.	Dickkopf WNT signaling pathway inhibitor 2.	0.948
LOC105940217	dkk3	ENSFHEP00000001212	ENSFHEP00000005528	Dickkopf WNT signaling pathway inhibitor 1a.	Dickkopf WNT signaling pathway inhibitor 3a.	0.511
cbl	LOC105929026	ENSFHEP00000004854	ENSFHEP00000019459	Cbl proto-oncogene, E3 ubiquitin protein ligase.	Uncharacterized protein.	0.944
cbl	LOC105939656	ENSFHEP00000004854	ENSFHEP00000024806	Cbl proto-oncogene, E3 ubiquitin protein ligase.	Cbl proto-oncogene C, E3 ubiquitin protein ligase.	0.944
dkk2	LOC105919329	ENSFHEP00000005193	ENSFHEP00000012676	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf-related protein 2.	0.902
dkk2	LOC105929638	ENSFHEP00000005193	ENSFHEP00000020065	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 3b.	0.412
dkk2	LOC105940217	ENSFHEP00000005193	ENSFHEP00000001212	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 1a.	0.948