62 items (Fundulus heteroclitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (463 aa)
	msx1	Muscle segment homeobox 1a. (281 aa)
	faf1	Fas (TNFRSF6) associated factor 1. (674 aa)
	bax	Uncharacterized protein. (240 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	ctsh	Uncharacterized protein; Belongs to the peptidase C1 family. (357 aa)
	LOC105933971	Uncharacterized protein. (305 aa)
	LOC105916681	Integral membrane protein 2Cb. (256 aa)
	ptprc	Uncharacterized protein. (989 aa)
	traf7	TNF receptor-associated factor 7. (637 aa)
	fadd	Uncharacterized protein. (195 aa)
	LOC105919183	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (498 aa)
	nkx3-1	NK3 homeobox 1. (187 aa)
	LOC105935372	Non-specific serine/threonine protein kinase. (513 aa)
	LOC105935999	RanBP-type and C3HC4-type zinc finger-containing protein 1. (510 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	flcn	Folliculin. (564 aa)
	srpx	Sushi-repeat containing protein X-linked. (430 aa)
	LOC105917085	Mitogen-activated protein kinase. (420 aa)
	LOC105931540	Uncharacterized protein. (304 aa)
	atf3	Activating transcription factor 3. (213 aa)
	LOC105921852	TGFb_propeptide domain-containing protein. (373 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (713 aa)
	ENSFHEP00000026343	SKI-like proto-oncogene a. (264 aa)
	zswim2	Zinc finger, SWIM-type containing 2. (497 aa)
	sirt1	Sirtuin 1. (719 aa)
	fbh1	F-box DNA helicase 1. (1099 aa)
	ENSFHEP00000023885	Muscle segment homeobox 3. (247 aa)
	bad	BCL2 associated agonist of cell death b. (209 aa)
	nfatc4	Nuclear factor of activated T cells 4. (897 aa)
	eef1e1	Eukaryotic translation elongation factor 1 epsilon 1. (173 aa)
	nf1	Neurofibromin 1b. (2547 aa)
	LOC105938713	Receptor-interacting serine-threonine kinase 3. (436 aa)
	LOC105940240	Uncharacterized protein. (314 aa)
	LOC105937498	Nerve growth factor receptor a (TNFR superfamily, member 16). (313 aa)
	ENSFHEP00000019671	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (184 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (503 aa)
	styxl1	Serine/threonine/tyrosine interacting-like 1. (296 aa)
	LOC105919181	Uncharacterized protein. (975 aa)
	pea15	Proliferation and apoptosis adaptor protein 15. (200 aa)
	LOC105929623	Uncharacterized protein. (268 aa)
	LOC105922614	Cylindromatosis (turban tumor syndrome), b. (734 aa)
	LOC105919212	Interleukin 20 receptor, alpha. (621 aa)
	LOC105922275	Inhibin subunit beta B. (394 aa)
	LOC105935349	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
	LOC105918599	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (769 aa)
	ddit3	DNA-damage-inducible transcript 3. (313 aa)
	LOC105922368	Inhibin subunit beta Ab. (396 aa)
	gsdme	Gasdermin Eb. (468 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (510 aa)
	LOC105929179	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	ENSFHEP00000012256	Gasdermin domain-containing protein. (140 aa)
	nck1	Cytoplasmic protein. (396 aa)
	ENSFHEP00000012082	Uncharacterized protein. (51 aa)
	ITM2C	Integral membrane protein 2C. (290 aa)
	nck2	Cytoplasmic protein. (395 aa)
	ENSFHEP00000011407	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (525 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (950 aa)
	dedd2	Death effector domain containing 2. (280 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	tpd52l1	Tpd52 like 1. (294 aa)
	LOC105930061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000011407	LOC105917085	ENSFHEP00000011407	ENSFHEP00000028879	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Mitogen-activated protein kinase.	0.769
ENSFHEP00000011407	LOC105929623	ENSFHEP00000011407	ENSFHEP00000017618	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.573
ENSFHEP00000011407	LOC105933971	ENSFHEP00000011407	ENSFHEP00000002054	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.573
ENSFHEP00000011407	bax	ENSFHEP00000011407	ENSFHEP00000004805	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Uncharacterized protein.	0.573
ENSFHEP00000011407	casp2	ENSFHEP00000011407	ENSFHEP00000012975	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.414
ENSFHEP00000011407	pea15	ENSFHEP00000011407	ENSFHEP00000018212	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Proliferation and apoptosis adaptor protein 15.	0.414
ENSFHEP00000011407	sirt1	ENSFHEP00000011407	ENSFHEP00000025372	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Sirtuin 1.	0.850
ENSFHEP00000012256	casp2	ENSFHEP00000012256	ENSFHEP00000012975	Gasdermin domain-containing protein.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.598
LOC105917085	ENSFHEP00000011407	ENSFHEP00000028879	ENSFHEP00000011407	Mitogen-activated protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.769
LOC105917085	LOC105919183	ENSFHEP00000028879	ENSFHEP00000033309	Mitogen-activated protein kinase.	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily.	0.558
LOC105917085	LOC105929623	ENSFHEP00000028879	ENSFHEP00000017618	Mitogen-activated protein kinase.	Uncharacterized protein.	0.485
LOC105917085	LOC105933971	ENSFHEP00000028879	ENSFHEP00000002054	Mitogen-activated protein kinase.	Uncharacterized protein.	0.485
LOC105917085	LOC105935372	ENSFHEP00000028879	ENSFHEP00000031369	Mitogen-activated protein kinase.	Non-specific serine/threonine protein kinase.	0.453
LOC105917085	LOC105938713	ENSFHEP00000028879	ENSFHEP00000022143	Mitogen-activated protein kinase.	Receptor-interacting serine-threonine kinase 3.	0.574
LOC105917085	LOC105940240	ENSFHEP00000028879	ENSFHEP00000021980	Mitogen-activated protein kinase.	Uncharacterized protein.	0.431
LOC105917085	atf3	ENSFHEP00000028879	ENSFHEP00000027984	Mitogen-activated protein kinase.	Activating transcription factor 3.	0.748
LOC105917085	bad	ENSFHEP00000028879	ENSFHEP00000023862	Mitogen-activated protein kinase.	BCL2 associated agonist of cell death b.	0.957
LOC105917085	bax	ENSFHEP00000028879	ENSFHEP00000004805	Mitogen-activated protein kinase.	Uncharacterized protein.	0.502
LOC105917085	fadd	ENSFHEP00000028879	ENSFHEP00000033591	Mitogen-activated protein kinase.	Uncharacterized protein.	0.494
LOC105917085	pak2	ENSFHEP00000028879	ENSFHEP00000000333	Mitogen-activated protein kinase.	Non-specific serine/threonine protein kinase.	0.452