(42 nodes) PML body network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105925662	Zgc:162297. (271 aa)
	LOC105940225	Phosphatase and tensin homolog. (340 aa)
	ENSFHEP00000001801	Bloom syndrome, RecQ helicase. (1405 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	CIITA	Class II major histocompatibility complex transactivator. (930 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (643 aa)
	LOC105937167	Ubiquitin-like domain-containing protein. (133 aa)
	chek2	Checkpoint kinase 2. (458 aa)
	HSF1	Heat shock transcription factor 1. (586 aa)
	mlip	Uncharacterized protein. (859 aa)
	gcna	Germ cell nuclear acidic peptidase. (706 aa)
	LOC105939042	Small ubiquitin like modifier 3. (158 aa)
	LOC105916077	Nedd4 binding protein 1. (687 aa)
	ankrd1	Ankyrin repeat domain 1a (cardiac muscle). (314 aa)
	rdm1	Zgc:103564. (299 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1270 aa)
	RPA1	Uncharacterized protein. (253 aa)
	LOC105916434	Endo/exonuclease/phosphatase domain-containing protein. (287 aa)
	ENSFHEP00000012850	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (466 aa)
	rnf6	Ring finger protein (C3H2C3 type) 6. (709 aa)
	ENSFHEP00000016114	Uncharacterized protein. (163 aa)
	ENSFHEP00000016131	Uncharacterized protein. (133 aa)
	LOC105915784	Transmembrane phosphatase with tensin homology. (511 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (414 aa)
	LOC105919182	KH and NYN domain containing. (992 aa)
	zbtb16	Zinc finger and BTB domain containing 16a. (664 aa)
	tp53inp2	Uncharacterized protein. (291 aa)
	ENSFHEP00000022489	Morc6_S5 domain-containing protein. (306 aa)
	LOC105926537	Heat shock transcription factor 4. (414 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa)
	LOC105933585	Small ubiquitin-related modifier. (96 aa)
	klhl20	Kelch-like family member 20. (554 aa)
	LOC105938715	RING-type domain-containing protein. (602 aa)
	calcoco2	Calcium binding and coiled-coil domain 2. (598 aa)
	casp8ap2	Uncharacterized protein. (1760 aa)
	rnf4	RING-type domain-containing protein. (185 aa)
	daxx	Death-domain associated protein. (737 aa)
	LOC105930441	Tyrosyl-DNA phosphodiesterase 2b. (325 aa)
	rnf111	Ring finger protein 111. (992 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (286 aa)
	rpain	RPA interacting protein. (223 aa)
	LOC105925663	Tumor protein p53-inducible nuclear protein 1. (163 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000001801	LOC105933585	ENSFHEP00000001801	ENSFHEP00000023052	Bloom syndrome, RecQ helicase.	Small ubiquitin-related modifier.	0.814
ENSFHEP00000001801	LOC105937167	ENSFHEP00000001801	ENSFHEP00000006742	Bloom syndrome, RecQ helicase.	Ubiquitin-like domain-containing protein.	0.814
ENSFHEP00000001801	LOC105939042	ENSFHEP00000001801	ENSFHEP00000008597	Bloom syndrome, RecQ helicase.	Small ubiquitin like modifier 3.	0.814
ENSFHEP00000001801	RPA1	ENSFHEP00000001801	ENSFHEP00000011881	Bloom syndrome, RecQ helicase.	Uncharacterized protein.	0.996
ENSFHEP00000001801	chek2	ENSFHEP00000001801	ENSFHEP00000006857	Bloom syndrome, RecQ helicase.	Checkpoint kinase 2.	0.809
ENSFHEP00000001801	rnf4	ENSFHEP00000001801	ENSFHEP00000027055	Bloom syndrome, RecQ helicase.	RING-type domain-containing protein.	0.415
ENSFHEP00000001801	rpa1	ENSFHEP00000001801	ENSFHEP00000022905	Bloom syndrome, RecQ helicase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.995
ENSFHEP00000001801	sumo2	ENSFHEP00000001801	ENSFHEP00000002112	Bloom syndrome, RecQ helicase.	Small ubiquitin-related modifier.	0.814
HSF1	RPA1	ENSFHEP00000007108	ENSFHEP00000011881	Heat shock transcription factor 1.	Uncharacterized protein.	0.590
HSF1	rpa1	ENSFHEP00000007108	ENSFHEP00000022905	Heat shock transcription factor 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.590
LOC105916434	LOC105933585	ENSFHEP00000012101	ENSFHEP00000023052	Endo/exonuclease/phosphatase domain-containing protein.	Small ubiquitin-related modifier.	0.569
LOC105916434	LOC105937167	ENSFHEP00000012101	ENSFHEP00000006742	Endo/exonuclease/phosphatase domain-containing protein.	Ubiquitin-like domain-containing protein.	0.569
LOC105916434	LOC105939042	ENSFHEP00000012101	ENSFHEP00000008597	Endo/exonuclease/phosphatase domain-containing protein.	Small ubiquitin like modifier 3.	0.569
LOC105916434	sumo2	ENSFHEP00000012101	ENSFHEP00000002112	Endo/exonuclease/phosphatase domain-containing protein.	Small ubiquitin-related modifier.	0.569
LOC105926537	RPA1	ENSFHEP00000022781	ENSFHEP00000011881	Heat shock transcription factor 4.	Uncharacterized protein.	0.590
LOC105926537	rpa1	ENSFHEP00000022781	ENSFHEP00000022905	Heat shock transcription factor 4.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.590
LOC105930441	LOC105933585	ENSFHEP00000028774	ENSFHEP00000023052	Tyrosyl-DNA phosphodiesterase 2b.	Small ubiquitin-related modifier.	0.640
LOC105930441	LOC105937167	ENSFHEP00000028774	ENSFHEP00000006742	Tyrosyl-DNA phosphodiesterase 2b.	Ubiquitin-like domain-containing protein.	0.640
LOC105930441	LOC105939042	ENSFHEP00000028774	ENSFHEP00000008597	Tyrosyl-DNA phosphodiesterase 2b.	Small ubiquitin like modifier 3.	0.640
LOC105930441	sumo2	ENSFHEP00000028774	ENSFHEP00000002112	Tyrosyl-DNA phosphodiesterase 2b.	Small ubiquitin-related modifier.	0.640