(56 nodes) WW domain network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	wwc3	WWC family member 3. (1205 aa)
	yap1	Yes-associated protein 1. (429 aa)
	magi3	Membrane associated guanylate kinase, WW and PDZ domain containing 3b. (1475 aa)
	TCERG1	Transcription elongation regulator 1. (890 aa)
	wwp2	E3 ubiquitin-protein ligase. (861 aa)
	LOC110368626	Growth arrest specific 7. (461 aa)
	ENSFHEP00000032358	Dystrophin. (1216 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (716 aa)
	wwp1	WW domain containing E3 ubiquitin protein ligase 1. (966 aa)
	iqgap1	IQ motif containing GTPase activating protein 1. (1571 aa)
	mlh3	WW domain-containing protein. (374 aa)
	LOC105919829	Uncharacterized protein. (385 aa)
	drp2	Dystrophin related protein 2. (878 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2581 aa)
	wac	WW domain containing adaptor with coiled-coil a. (541 aa)
	apbb3	Amyloid beta (A4) precursor protein-binding, family B, member 3. (399 aa)
	sav1	Salvador family WW domain containing protein 1. (401 aa)
	iqgap2	IQ motif containing GTPase activating protein 2. (1521 aa)
	dgcr8	DGCR8 microprocessor complex subunit. (777 aa)
	LOC105935182	Uncharacterized protein. (1038 aa)
	LOC105935574	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1538 aa)
	LOC105937166	PRP40 pre-mRNA processing factor 40 homolog A. (764 aa)
	ARHGAP12	Rho GTPase activating protein 12. (905 aa)
	ENSFHEP00000006905	WW domain-containing protein. (496 aa)
	PLEKHA5	Pleckstrin homology domain containing A5. (1163 aa)
	apbb1	Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (686 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1112 aa)
	fnbp4	Formin binding protein 4. (876 aa)
	LOC105925884	E3 ubiquitin-protein ligase. (880 aa)
	LOC105920636	Uncharacterized protein. (362 aa)
	smurf1	E3 ubiquitin-protein ligase. (729 aa)
	LOC105929913	E3 ubiquitin-protein ligase. (770 aa)
	LOC105920558	Uncharacterized protein. (1034 aa)
	LOC105930942	Uncharacterized protein. (846 aa)
	ITCH	Itchy E3 ubiquitin protein ligase. (445 aa)
	wwc1	WW and C2 domain containing 1. (1130 aa)
	SMURF2	E3 ubiquitin-protein ligase. (785 aa)
	arhgap39	Zgc:92107. (1133 aa)
	wbp4	Uncharacterized protein. (393 aa)
	LOC105932504	Rho GTPase activating protein 27. (986 aa)
	LOC105923572	NEDD4 like E3 ubiquitin protein ligase. (440 aa)
	hecw2	Uncharacterized protein. (1546 aa)
	LOC105926237	Pleckstrin homology domain containing, family A member 7a. (1306 aa)
	wwox	WW domain containing oxidoreductase. (394 aa)
	LOC105930296	WW domain-containing protein. (529 aa)
	LOC105916280	Pleckstrin homology domain containing, family A member 7b. (1275 aa)
	pqbp1	Polyglutamine binding protein 1. (234 aa)
	LOC105939853	Uncharacterized protein. (928 aa)
	ENSFHEP00000021313	Uncharacterized protein. (598 aa)
	cmtr1	Cap methyltransferase 1. (828 aa)
	LOC105926066	Membrane associated guanylate kinase, WW and PDZ domain containing 1a. (1486 aa)
	magi1	Membrane associated guanylate kinase, WW and PDZ domain containing 1b. (1144 aa)
	pcif1	PDX1 C-terminal inhibiting factor 1. (610 aa)
	iqgap3	IQ motif containing GTPase activating protein 3. (1564 aa)
	ENSFHEP00000025475	WW domain-containing protein. (184 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP12	iqgap1	ENSFHEP00000006683	ENSFHEP00000031621	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 1.	0.564
ARHGAP12	iqgap2	ENSFHEP00000006683	ENSFHEP00000005788	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 2.	0.564
ARHGAP12	iqgap3	ENSFHEP00000006683	ENSFHEP00000025385	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 3.	0.564
ARHGAP12	yap1	ENSFHEP00000006683	ENSFHEP00000029511	Rho GTPase activating protein 12.	Yes-associated protein 1.	0.514
ENSFHEP00000025475	fnbp4	ENSFHEP00000025475	ENSFHEP00000008467	WW domain-containing protein.	Formin binding protein 4.	0.405
ENSFHEP00000025475	sav1	ENSFHEP00000025475	ENSFHEP00000002850	WW domain-containing protein.	Salvador family WW domain containing protein 1.	0.633
HECW1	ITCH	ENSFHEP00000008331	ENSFHEP00000014178	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	Itchy E3 ubiquitin protein ligase.	0.546
HECW1	LOC105925884	ENSFHEP00000008331	ENSFHEP00000008476	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	E3 ubiquitin-protein ligase.	0.546
HECW1	LOC105929913	ENSFHEP00000008331	ENSFHEP00000009714	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	E3 ubiquitin-protein ligase.	0.572
HECW1	SMURF2	ENSFHEP00000008331	ENSFHEP00000015331	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	E3 ubiquitin-protein ligase.	0.572
HECW1	sav1	ENSFHEP00000008331	ENSFHEP00000002850	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	Salvador family WW domain containing protein 1.	0.623
HECW1	smurf1	ENSFHEP00000008331	ENSFHEP00000009383	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	E3 ubiquitin-protein ligase.	0.572
HECW1	wwp1	ENSFHEP00000008331	ENSFHEP00000031986	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	WW domain containing E3 ubiquitin protein ligase 1.	0.546
HECW1	wwp2	ENSFHEP00000008331	ENSFHEP00000033372	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	E3 ubiquitin-protein ligase.	0.546
ITCH	HECW1	ENSFHEP00000014178	ENSFHEP00000008331	Itchy E3 ubiquitin protein ligase.	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1.	0.546
ITCH	LOC105923572	ENSFHEP00000014178	ENSFHEP00000017850	Itchy E3 ubiquitin protein ligase.	NEDD4 like E3 ubiquitin protein ligase.	0.743
ITCH	LOC105925884	ENSFHEP00000014178	ENSFHEP00000008476	Itchy E3 ubiquitin protein ligase.	E3 ubiquitin-protein ligase.	0.939
ITCH	NEDD4	ENSFHEP00000014178	ENSFHEP00000032344	Itchy E3 ubiquitin protein ligase.	NEDD4 E3 ubiquitin protein ligase.	0.745
ITCH	SMURF2	ENSFHEP00000014178	ENSFHEP00000015331	Itchy E3 ubiquitin protein ligase.	E3 ubiquitin-protein ligase.	0.588
ITCH	hecw2	ENSFHEP00000014178	ENSFHEP00000017888	Itchy E3 ubiquitin protein ligase.	Uncharacterized protein.	0.546