(33 nodes) Guanine-nucleotide dissociation stimulator, CDC24, conserved site network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105939804	Si:dkey-91m11.5. (1292 aa)
	arhgef12	Rho guanine nucleotide exchange factor (GEF) 12a. (1411 aa)
	ABR	ABR activator of RhoGEF and GTPase. (1097 aa)
	arhgef1	Rho guanine nucleotide exchange factor (GEF) 1b. (1042 aa)
	NET1	Neuroepithelial cell-transforming gene 1 protein. (574 aa)
	tiam1	T cell lymphoma invasion and metastasis 1b. (1588 aa)
	LOC105920702	Intersectin 2b. (1844 aa)
	tiam2	T cell lymphoma invasion and metastasis 2a. (1729 aa)
	prex1	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1550 aa)
	arhgef11	Rho guanine nucleotide exchange factor (GEF) 11. (1372 aa)
	LOC105932130	BCR activator of RhoGEF and GTPase. (1374 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (790 aa)
	itsn1	Intersectin 1 (SH3 domain protein). (1580 aa)
	LOC105927585	Mcf.2 cell line derived transforming sequence-like b. (1085 aa)
	LOC105927556	Rho guanine nucleotide exchange factor (GEF) 7a. (787 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (803 aa)
	LOC105934939	Uncharacterized protein. (1453 aa)
	ect2	Epithelial cell transforming 2. (888 aa)
	mcf2	MCF.2 cell line derived transforming sequence a. (947 aa)
	LOC105922655	T cell lymphoma invasion and metastasis 1a. (1587 aa)
	arhgef3	Rho guanine nucleotide exchange factor (GEF) 3. (656 aa)
	LOC105935876	Rho guanine nucleotide exchange factor (GEF) 3, like. (499 aa)
	ENSFHEP00000019422	Uncharacterized protein. (845 aa)
	PLEKHG1	Pleckstrin homology and RhoGEF domain containing G1. (1564 aa)
	LOC105932314	Uncharacterized protein. (1163 aa)
	ENSFHEP00000025972	Uncharacterized protein. (512 aa)
	dnmbp	Dynamin binding protein. (1685 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1197 aa)
	LOC105929815	Neuroepithelial cell transforming 1. (634 aa)
	prex2	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1582 aa)
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (517 aa)
	arhgef38	Rho guanine nucleotide exchange factor (GEF) 38. (783 aa)
	LOC105927499	Uncharacterized protein. (1229 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF4	ENSFHEP00000025972	ENSFHEP00000033021	ENSFHEP00000025972	Rho guanine nucleotide exchange factor 4.	Uncharacterized protein.	0.610
ARHGEF4	LOC105920702	ENSFHEP00000033021	ENSFHEP00000007082	Rho guanine nucleotide exchange factor 4.	Intersectin 2b.	0.610
ARHGEF4	itsn1	ENSFHEP00000033021	ENSFHEP00000010978	Rho guanine nucleotide exchange factor 4.	Intersectin 1 (SH3 domain protein).	0.609
ENSFHEP00000025972	ARHGEF4	ENSFHEP00000025972	ENSFHEP00000033021	Uncharacterized protein.	Rho guanine nucleotide exchange factor 4.	0.610
ENSFHEP00000025972	LOC105920702	ENSFHEP00000025972	ENSFHEP00000007082	Uncharacterized protein.	Intersectin 2b.	0.985
ENSFHEP00000025972	LOC105922655	ENSFHEP00000025972	ENSFHEP00000016226	Uncharacterized protein.	T cell lymphoma invasion and metastasis 1a.	0.610
ENSFHEP00000025972	LOC105927499	ENSFHEP00000025972	ENSFHEP00000034819	Uncharacterized protein.	Uncharacterized protein.	0.610
ENSFHEP00000025972	LOC105927556	ENSFHEP00000025972	ENSFHEP00000011162	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 7a.	0.723
ENSFHEP00000025972	LOC105929815	ENSFHEP00000025972	ENSFHEP00000029942	Uncharacterized protein.	Neuroepithelial cell transforming 1.	0.627
ENSFHEP00000025972	LOC105932314	ENSFHEP00000025972	ENSFHEP00000022346	Uncharacterized protein.	Uncharacterized protein.	0.415
ENSFHEP00000025972	LOC105935876	ENSFHEP00000025972	ENSFHEP00000019302	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 3, like.	0.627
ENSFHEP00000025972	NET1	ENSFHEP00000025972	ENSFHEP00000005945	Uncharacterized protein.	Neuroepithelial cell-transforming gene 1 protein.	0.627
ENSFHEP00000025972	RASGRF1	ENSFHEP00000025972	ENSFHEP00000028114	Uncharacterized protein.	Ras protein specific guanine nucleotide releasing factor 1.	0.415
ENSFHEP00000025972	arhgef1	ENSFHEP00000025972	ENSFHEP00000005918	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 1b.	0.610
ENSFHEP00000025972	arhgef11	ENSFHEP00000025972	ENSFHEP00000009429	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 11.	0.610
ENSFHEP00000025972	arhgef12	ENSFHEP00000025972	ENSFHEP00000004952	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 12a.	0.610
ENSFHEP00000025972	arhgef3	ENSFHEP00000025972	ENSFHEP00000018018	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 3.	0.627
ENSFHEP00000025972	arhgef38	ENSFHEP00000025972	ENSFHEP00000034280	Uncharacterized protein.	Rho guanine nucleotide exchange factor (GEF) 38.	0.610
ENSFHEP00000025972	dnmbp	ENSFHEP00000025972	ENSFHEP00000026571	Uncharacterized protein.	Dynamin binding protein.	0.610
ENSFHEP00000025972	itsn1	ENSFHEP00000025972	ENSFHEP00000010978	Uncharacterized protein.	Intersectin 1 (SH3 domain protein).	0.983