(52 nodes) Pyridoxal phosphate-dependent transferase, major domain network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	alas1	5-aminolevulinate synthase. (619 aa)
	ENSFHEP00000015728	SHMT domain-containing protein. (48 aa)
	LOC105940129	Aminotran_1_2 domain-containing protein. (516 aa)
	ENSFHEP00000016229	Aminotran_1_2 domain-containing protein. (181 aa)
	LOC105930239	Glutamate decarboxylase 1b. (564 aa)
	LOC105937577	Serine--pyruvate aminotransferase. (429 aa)
	sptlc3	Serine palmitoyltransferase, long chain base subunit 3. (549 aa)
	etnppl	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	MOCOS	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (834 aa)
	LOC105924849	Serine palmitoyltransferase, long chain base subunit 1. (230 aa)
	LOC105933755	5-aminolevulinate synthase. (554 aa)
	oat	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa)
	LOC105916055	SHMT domain-containing protein. (483 aa)
	gcat	Glycine C-acetyltransferase. (427 aa)
	accs	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional). (995 aa)
	tat	Tyrosine aminotransferase. (573 aa)
	pdxdc1	Pyridoxal-dependent decarboxylase domain containing 1. (747 aa)
	ENSFHEP00000025794	Alanine--glyoxylate and serine--pyruvate aminotransferase a. (256 aa)
	LOC105932871	Aminotran_1_2 domain-containing protein. (446 aa)
	ddc	Dopa decarboxylase. (432 aa)
	gpt	Si:ch211-217a12.1. (543 aa)
	gad2	Glutamate decarboxylase 2. (529 aa)
	kyat3	Kynurenine aminotransferase 3. (470 aa)
	psat1	Phosphoserine aminotransferase. (373 aa)
	agxt2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
	cth	Cystathionase (cystathionine gamma-lyase), like. (408 aa)
	nfs1	NFS1 cysteine desulfurase. (449 aa)
	GOT1	Aspartate aminotransferase. (410 aa)
	got1	Aspartate aminotransferase. (410 aa)
	kyat1	Kynurenine aminotransferase 1. (445 aa)
	abat	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	ENSFHEP00000021849	SHMT domain-containing protein. (169 aa)
	csad	Cysteine sulfinic acid decarboxylase. (512 aa)
	sepsecs	O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (486 aa)
	aadat	Aminoadipate aminotransferase. (434 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (512 aa)
	LOC105930627	Serine palmitoyltransferase, long chain base subunit 2b. (571 aa)
	got2	Aspartate aminotransferase. (428 aa)
	LOC105932857	Aminotran_1_2 domain-containing protein. (565 aa)
	LOC105920782	Glutamate decarboxylase 1a. (444 aa)
	hdc	Histidine decarboxylase. (630 aa)
	kynu	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (454 aa)
	sptlc1	Serine palmitoyltransferase, long chain base subunit 1. (251 aa)
	LOC105916057	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
	LOC105928263	Threonine aldolase 1. (425 aa)
	scly	Selenocysteine lyase. (407 aa)
	gadl1	Uncharacterized protein. (492 aa)
	GADL1	Glutamate decarboxylase like 1. (451 aa)
	phykpl	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
	LOC105935391	Aminotran_1_2 domain-containing protein. (532 aa)
	sgpl1	Sphingosine-1-phosphate lyase 1. (565 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000015728	ENSFHEP00000016229	ENSFHEP00000015728	ENSFHEP00000016229	SHMT domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.906
ENSFHEP00000015728	ENSFHEP00000025794	ENSFHEP00000015728	ENSFHEP00000025794	SHMT domain-containing protein.	Alanine--glyoxylate and serine--pyruvate aminotransferase a.	0.933
ENSFHEP00000015728	GADL1	ENSFHEP00000015728	ENSFHEP00000007130	SHMT domain-containing protein.	Glutamate decarboxylase like 1.	0.416
ENSFHEP00000015728	LOC105920782	ENSFHEP00000015728	ENSFHEP00000005548	SHMT domain-containing protein.	Glutamate decarboxylase 1a.	0.416
ENSFHEP00000015728	LOC105924849	ENSFHEP00000015728	ENSFHEP00000031893	SHMT domain-containing protein.	Serine palmitoyltransferase, long chain base subunit 1.	0.904
ENSFHEP00000015728	LOC105928263	ENSFHEP00000015728	ENSFHEP00000009297	SHMT domain-containing protein.	Threonine aldolase 1.	0.942
ENSFHEP00000015728	LOC105930239	ENSFHEP00000015728	ENSFHEP00000017419	SHMT domain-containing protein.	Glutamate decarboxylase 1b.	0.416
ENSFHEP00000015728	LOC105930627	ENSFHEP00000015728	ENSFHEP00000004346	SHMT domain-containing protein.	Serine palmitoyltransferase, long chain base subunit 2b.	0.912
ENSFHEP00000015728	LOC105932857	ENSFHEP00000015728	ENSFHEP00000004879	SHMT domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.498
ENSFHEP00000015728	LOC105932871	ENSFHEP00000015728	ENSFHEP00000024432	SHMT domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.498
ENSFHEP00000015728	LOC105933755	ENSFHEP00000015728	ENSFHEP00000030596	SHMT domain-containing protein.	5-aminolevulinate synthase.	0.912
ENSFHEP00000015728	LOC105935391	ENSFHEP00000015728	ENSFHEP00000012121	SHMT domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.498
ENSFHEP00000015728	LOC105937577	ENSFHEP00000015728	ENSFHEP00000034786	SHMT domain-containing protein.	Serine--pyruvate aminotransferase.	0.933
ENSFHEP00000015728	LOC105940129	ENSFHEP00000015728	ENSFHEP00000016184	SHMT domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.526
ENSFHEP00000015728	MOCOS	ENSFHEP00000015728	ENSFHEP00000032243	SHMT domain-containing protein.	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.	0.715
ENSFHEP00000015728	abat	ENSFHEP00000015728	ENSFHEP00000001140	SHMT domain-containing protein.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.512
ENSFHEP00000015728	accs	ENSFHEP00000015728	ENSFHEP00000026673	SHMT domain-containing protein.	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional).	0.441
ENSFHEP00000015728	agxt2	ENSFHEP00000015728	ENSFHEP00000003628	SHMT domain-containing protein.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.917
ENSFHEP00000015728	alas1	ENSFHEP00000015728	ENSFHEP00000013985	SHMT domain-containing protein.	5-aminolevulinate synthase.	0.906
ENSFHEP00000015728	csad	ENSFHEP00000015728	ENSFHEP00000021250	SHMT domain-containing protein.	Cysteine sulfinic acid decarboxylase.	0.416