(100 nodes) Tyrosine-protein kinase, catalytic domain network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105935747	Tyrosine kinase, non-receptor, 2a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (893 aa)
	tie1	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1138 aa)
	tec	Tyrosine-protein kinase. (721 aa)
	ntrk3	Tyrosine-protein kinase receptor. (786 aa)
	LOC105916745	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (905 aa)
	LOC105937265	Tyrosine-protein kinase. (1122 aa)
	LOC105919586	Receptor protein-tyrosine kinase. (1102 aa)
	LOC105933955	Tyrosine-protein kinase receptor. (1412 aa)
	abl2	Tyrosine-protein kinase. (1188 aa)
	matk	Tyrosine-protein kinase. (459 aa)
	ENSFHEP00000004709	Tyrosine-protein kinase receptor. (560 aa)
	LOC105936814	Tyrosine-protein kinase receptor. (1329 aa)
	mertk	C-mer proto-oncogene tyrosine kinase a. (932 aa)
	LOC105918901	TYRO3 protein tyrosine kinase. (349 aa)
	LOC105925563	Tyrosine-protein kinase. (532 aa)
	erbb4	Receptor protein-tyrosine kinase. (1235 aa)
	LOC105915447	Uncharacterized protein. (934 aa)
	LOC105918256	Tyrosine-protein kinase receptor. (777 aa)
	flt4	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
	ENSFHEP00000008051	Erb-b2 receptor tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (594 aa)
	LOC105938599	Tyrosine-protein kinase. (499 aa)
	epha3	Ephrin type-A receptor 3. (994 aa)
	EPHA6	EPH receptor A6. (985 aa)
	LOC105939053	Tyrosine-protein kinase. (537 aa)
	fyn	Tyrosine-protein kinase. (588 aa)
	igf1r	Tyrosine-protein kinase receptor. (1413 aa)
	ENSFHEP00000010079	Uncharacterized protein. (897 aa)
	LOC105937088	Receptor protein-tyrosine kinase. (1173 aa)
	ephb2	Eph receptor B2b. (906 aa)
	hck	Tyrosine-protein kinase. (505 aa)
	SRC	Tyrosine-protein kinase. (548 aa)
	kit	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	LOC105918234	Tyrosine-protein kinase. (550 aa)
	btk	Tyrosine-protein kinase. (638 aa)
	tnk2	Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1208 aa)
	csf1r	Colony stimulating factor 1 receptor, a. (984 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
	ephb4	Eph receptor B4a. (987 aa)
	LOC105916945	Si:ch73-40a2.1. (840 aa)
	jak3	Tyrosine-protein kinase. (1105 aa)
	syk	Tyrosine-protein kinase. (621 aa)
	LOC105925783	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1331 aa)
	LOC105925292	Discoidin domain receptor tyrosine kinase 2b. (836 aa)
	LOC105915846	Tyrosine-protein kinase. (494 aa)
	LOC105915845	Tyrosine-protein kinase. (502 aa)
	flt1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1273 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
	CSK	Tyrosine-protein kinase. (388 aa)
	mst1r	Macrophage-stimulating protein receptor. (1375 aa)
	LOC105934221	Uncharacterized protein. (986 aa)
	LOC105920313	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
	LOC105939348	Fibroblast growth factor receptor. (899 aa)
	LOC105933677	Macrophage stimulating 1 receptor a. (1409 aa)
	epha4	Eph receptor A4, like. (989 aa)
	ENSFHEP00000019798	Tyrosine-protein kinase receptor. (564 aa)
	LOC105936452	Tyrosine-protein kinase. (511 aa)
	LOC105938148	Tyrosine-protein kinase receptor. (743 aa)
	ddr2	Discoidin domain receptor tyrosine kinase 2a. (720 aa)
	LOC105928781	Fibroblast growth factor receptor. (829 aa)
	LOC105921945	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (823 aa)
	jak1	Tyrosine-protein kinase. (1184 aa)
	tyk2	Tyrosine-protein kinase. (1159 aa)
	LOC105936962	Uncharacterized protein. (998 aa)
	tnk1	Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (510 aa)
	LOC105918495	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
	LOC105918963	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (861 aa)
	frk	Tyrosine-protein kinase. (486 aa)
	ENSFHEP00000024673	Protein kinase domain-containing protein. (129 aa)
	epha5	Uncharacterized protein. (809 aa)
	epha7	Eph receptor A7. (992 aa)
	LOC105927698	Tyrosine-protein kinase receptor. (1458 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	fgfr3	Fibroblast growth factor receptor. (838 aa)
	LOC105920095	Eph receptor B2a. (963 aa)
	LOC105935090	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1098 aa)
	insr	Insulin receptor a. (1279 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1372 aa)
	ddr1	Discoidin domain receptor tyrosine kinase 1. (1025 aa)
	LOC105917056	Fibroblast growth factor receptor. (694 aa)
	YES1	Tyrosine-protein kinase. (516 aa)
	LOC105932126	Tyrosine-protein kinase. (1129 aa)
	LOC105925890	Eph receptor A2 b. (989 aa)
	ntrk1	Tyrosine-protein kinase receptor. (742 aa)
	ret	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1039 aa)
	LOC105934940	Receptor protein-tyrosine kinase. (1004 aa)
	LOC105925188	Eph receptor B3a. (926 aa)
	ENSFHEP00000031486	Fibroblast growth factor receptor. (690 aa)
	LOC105916349	Eph receptor A6. (965 aa)
	LOC105935923	EPH receptor B1. (980 aa)
	abl1	Tyrosine-protein kinase. (1105 aa)
	LOC105920338	Tyrosine-protein kinase. (548 aa)
	ENSFHEP00000032566	Tyrosine-protein kinase. (477 aa)
	LOC105934215	Eph receptor A4b. (983 aa)
	LOC105933666	Eph receptor A2 a. (979 aa)
	AXL	AXL receptor tyrosine kinase. (579 aa)
	LOC105939312	Tyrosine-protein kinase. (606 aa)
	LOC105921597	Discoidin domain receptor family, member 2, like. (811 aa)
	itk	Tyrosine-protein kinase. (634 aa)
	LOC105921477	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (948 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	CSK	ENSFHEP00000033946	ENSFHEP00000017922	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.517
AXL	ENSFHEP00000032566	ENSFHEP00000033946	ENSFHEP00000032566	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.585
AXL	LOC105915845	ENSFHEP00000033946	ENSFHEP00000014696	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.509
AXL	LOC105915846	ENSFHEP00000033946	ENSFHEP00000014692	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.538
AXL	LOC105918234	ENSFHEP00000033946	ENSFHEP00000012505	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.586
AXL	LOC105920338	ENSFHEP00000033946	ENSFHEP00000032191	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.556
AXL	LOC105925563	ENSFHEP00000033946	ENSFHEP00000006575	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.509
AXL	LOC105932126	ENSFHEP00000033946	ENSFHEP00000028283	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.546
AXL	LOC105936452	ENSFHEP00000033946	ENSFHEP00000020263	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.579
AXL	LOC105937265	ENSFHEP00000033946	ENSFHEP00000003402	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.546
AXL	LOC105938599	ENSFHEP00000033946	ENSFHEP00000008102	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.496
AXL	LOC105939053	ENSFHEP00000033946	ENSFHEP00000008682	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.509
AXL	SRC	ENSFHEP00000033946	ENSFHEP00000011333	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.585
AXL	YES1	ENSFHEP00000033946	ENSFHEP00000028207	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.580
AXL	frk	ENSFHEP00000033946	ENSFHEP00000024123	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.509
AXL	fyn	ENSFHEP00000033946	ENSFHEP00000009805	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.509
AXL	hck	ENSFHEP00000033946	ENSFHEP00000011161	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.556
AXL	jak1	ENSFHEP00000033946	ENSFHEP00000021544	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.546
AXL	jak3	ENSFHEP00000033946	ENSFHEP00000013483	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.546
AXL	lck	ENSFHEP00000033946	ENSFHEP00000025300	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.581