(20 nodes) Sec7 domain superfamily network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	iqsec3	IQ motif and Sec7 domain 3a. (1100 aa)
	LOC105938896	Cytohesin 4a. (397 aa)
	arfgef2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited). (1759 aa)
	LOC105918714	SEC7 domain-containing protein. (1210 aa)
	fbxo8	F-box protein 8. (320 aa)
	LOC105936291	Uncharacterized protein. (652 aa)
	cyth2	Cytohesin-2. (417 aa)
	iqsec2	IQ motif and Sec7 domain 2b. (1513 aa)
	LOC105930824	Uncharacterized protein. (1122 aa)
	psd2	Pleckstrin and Sec7 domain containing 2. (896 aa)
	LOC105940050	IQ motif and Sec7 domain 1b. (921 aa)
	LOC105928215	Cytohesin 1b. (420 aa)
	LOC105936180	Cytohesin 1a. (414 aa)
	LOC105915444	Cytohesin 4b. (397 aa)
	ENSFHEP00000007495	Pleckstrin and Sec7 domain containing a. (218 aa)
	LOC105935634	Cytohesin-1. (394 aa)
	ENSFHEP00000003138	SEC7 domain-containing protein. (346 aa)
	arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited). (1727 aa)
	IQSEC1	IQ motif and Sec7 domain 1. (1239 aa)
	LOC105921960	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (752 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000003138	ENSFHEP00000007495	ENSFHEP00000003138	ENSFHEP00000007495	SEC7 domain-containing protein.	Pleckstrin and Sec7 domain containing a.	0.452
ENSFHEP00000003138	LOC105915444	ENSFHEP00000003138	ENSFHEP00000007627	SEC7 domain-containing protein.	Cytohesin 4b.	0.459
ENSFHEP00000003138	LOC105928215	ENSFHEP00000003138	ENSFHEP00000009334	SEC7 domain-containing protein.	Cytohesin 1b.	0.459
ENSFHEP00000003138	LOC105930824	ENSFHEP00000003138	ENSFHEP00000016406	SEC7 domain-containing protein.	Uncharacterized protein.	0.452
ENSFHEP00000003138	LOC105935634	ENSFHEP00000003138	ENSFHEP00000005544	SEC7 domain-containing protein.	Cytohesin-1.	0.459
ENSFHEP00000003138	LOC105936180	ENSFHEP00000003138	ENSFHEP00000007832	SEC7 domain-containing protein.	Cytohesin 1a.	0.459
ENSFHEP00000003138	LOC105936291	ENSFHEP00000003138	ENSFHEP00000023580	SEC7 domain-containing protein.	Uncharacterized protein.	0.452
ENSFHEP00000003138	LOC105938896	ENSFHEP00000003138	ENSFHEP00000030004	SEC7 domain-containing protein.	Cytohesin 4a.	0.459
ENSFHEP00000003138	cyth2	ENSFHEP00000003138	ENSFHEP00000020841	SEC7 domain-containing protein.	Cytohesin-2.	0.459
ENSFHEP00000003138	psd2	ENSFHEP00000003138	ENSFHEP00000014690	SEC7 domain-containing protein.	Pleckstrin and Sec7 domain containing 2.	0.452
ENSFHEP00000007495	ENSFHEP00000003138	ENSFHEP00000007495	ENSFHEP00000003138	Pleckstrin and Sec7 domain containing a.	SEC7 domain-containing protein.	0.452
ENSFHEP00000007495	IQSEC1	ENSFHEP00000007495	ENSFHEP00000002162	Pleckstrin and Sec7 domain containing a.	IQ motif and Sec7 domain 1.	0.470
ENSFHEP00000007495	LOC105915444	ENSFHEP00000007495	ENSFHEP00000007627	Pleckstrin and Sec7 domain containing a.	Cytohesin 4b.	0.494
ENSFHEP00000007495	LOC105918714	ENSFHEP00000007495	ENSFHEP00000029002	Pleckstrin and Sec7 domain containing a.	SEC7 domain-containing protein.	0.470
ENSFHEP00000007495	LOC105921960	ENSFHEP00000007495	ENSFHEP00000000519	Pleckstrin and Sec7 domain containing a.	Golgi brefeldin A resistant guanine nucleotide exchange factor 1.	0.485
ENSFHEP00000007495	LOC105928215	ENSFHEP00000007495	ENSFHEP00000009334	Pleckstrin and Sec7 domain containing a.	Cytohesin 1b.	0.490
ENSFHEP00000007495	LOC105935634	ENSFHEP00000007495	ENSFHEP00000005544	Pleckstrin and Sec7 domain containing a.	Cytohesin-1.	0.490
ENSFHEP00000007495	LOC105936180	ENSFHEP00000007495	ENSFHEP00000007832	Pleckstrin and Sec7 domain containing a.	Cytohesin 1a.	0.490
ENSFHEP00000007495	LOC105938896	ENSFHEP00000007495	ENSFHEP00000030004	Pleckstrin and Sec7 domain containing a.	Cytohesin 4a.	0.474
ENSFHEP00000007495	LOC105940050	ENSFHEP00000007495	ENSFHEP00000010584	Pleckstrin and Sec7 domain containing a.	IQ motif and Sec7 domain 1b.	0.470