(12 nodes) Insulin-like superfamily network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC105925225	IlGF domain-containing protein. (105 aa)
	igf1	Insulin growth factor I-like protein. (185 aa)
	ENSFHEP00000004915	Uncharacterized protein. (59 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
	LOC105917639	Relaxin-3. (104 aa)
	ENSFHEP00000013403	Uncharacterized protein. (79 aa)
	ENSFHEP00000020440	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (55 aa)
	LOC105924364	IlGF domain-containing protein. (139 aa)
	rln3	Relaxin 3b. (146 aa)
	LOC105918211	Insulin-like growth factor 2b. (215 aa)
	LOC105932139	Relaxin 1. (179 aa)
	RLN3	Relaxin 3a. (147 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000004915	ENSFHEP00000013403	ENSFHEP00000004915	ENSFHEP00000013403	Uncharacterized protein.	Uncharacterized protein.	0.414
ENSFHEP00000004915	LOC105917639	ENSFHEP00000004915	ENSFHEP00000009786	Uncharacterized protein.	Relaxin-3.	0.868
ENSFHEP00000004915	LOC105924364	ENSFHEP00000004915	ENSFHEP00000022357	Uncharacterized protein.	IlGF domain-containing protein.	0.519
ENSFHEP00000004915	LOC105925225	ENSFHEP00000004915	ENSFHEP00000014216	Uncharacterized protein.	IlGF domain-containing protein.	0.414
ENSFHEP00000004915	LOC105932139	ENSFHEP00000004915	ENSFHEP00000028335	Uncharacterized protein.	Relaxin 1.	0.634
ENSFHEP00000004915	RLN3	ENSFHEP00000004915	ENSFHEP00000030850	Uncharacterized protein.	Relaxin 3a.	0.750
ENSFHEP00000013403	ENSFHEP00000004915	ENSFHEP00000013403	ENSFHEP00000004915	Uncharacterized protein.	Uncharacterized protein.	0.414
ENSFHEP00000013403	LOC105932139	ENSFHEP00000013403	ENSFHEP00000028335	Uncharacterized protein.	Relaxin 1.	0.617
ENSFHEP00000020440	LOC105918211	ENSFHEP00000020440	ENSFHEP00000027489	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor 2b.	0.766
ENSFHEP00000020440	LOC105924364	ENSFHEP00000020440	ENSFHEP00000022357	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	IlGF domain-containing protein.	0.783
ENSFHEP00000020440	igf1	ENSFHEP00000020440	ENSFHEP00000002734	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin growth factor I-like protein.	0.862
LOC105917639	ENSFHEP00000004915	ENSFHEP00000009786	ENSFHEP00000004915	Relaxin-3.	Uncharacterized protein.	0.868
LOC105917639	LOC105925225	ENSFHEP00000009786	ENSFHEP00000014216	Relaxin-3.	IlGF domain-containing protein.	0.615
LOC105917639	LOC105932139	ENSFHEP00000009786	ENSFHEP00000028335	Relaxin-3.	Relaxin 1.	0.572
LOC105917639	RLN3	ENSFHEP00000009786	ENSFHEP00000030850	Relaxin-3.	Relaxin 3a.	0.932
LOC105917639	rln3	ENSFHEP00000009786	ENSFHEP00000026659	Relaxin-3.	Relaxin 3b.	0.949
LOC105918211	ENSFHEP00000020440	ENSFHEP00000027489	ENSFHEP00000020440	Insulin-like growth factor 2b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.766
LOC105918211	LOC105924364	ENSFHEP00000027489	ENSFHEP00000022357	Insulin-like growth factor 2b.	IlGF domain-containing protein.	0.456
LOC105918211	igf1	ENSFHEP00000027489	ENSFHEP00000002734	Insulin-like growth factor 2b.	Insulin growth factor I-like protein.	0.907
LOC105918211	ins	ENSFHEP00000027489	ENSFHEP00000005373	Insulin-like growth factor 2b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.766