(17 nodes) Synthesis, secretion, and deacylation of Ghrelin network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC105940210	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (589 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (773 aa)
	ENSFHEP00000030023	COesterase domain-containing protein. (275 aa)
	LOC105932808	Growth hormone 1. (213 aa)
	ENSFHEP00000024666	COesterase domain-containing protein. (163 aa)
	pla2g7	Platelet-activating factor acetylhydrolase. (483 aa)
	gcg	Glucagon b. (123 aa)
	ENSFHEP00000020440	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (55 aa)
	spcs2	Signal peptidase complex subunit 2. (232 aa)
	ENSFHEP00000019690	Signal peptidase complex subunit 2. (106 aa)
	spcs1	Signal peptidase complex subunit 1. (102 aa)
	sec11a	Signal peptidase complex catalytic subunit SEC11. (179 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (616 aa)
	ins	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
	spcs3	Signal peptidase complex subunit 3. (223 aa)
	igf1	Insulin growth factor I-like protein. (185 aa)
	ENSFHEP00000002199	Uncharacterized protein. (276 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000019690	sec11a	ENSFHEP00000019690	ENSFHEP00000010807	Signal peptidase complex subunit 2.	Signal peptidase complex catalytic subunit SEC11.	0.979
ENSFHEP00000019690	spcs1	ENSFHEP00000019690	ENSFHEP00000019060	Signal peptidase complex subunit 2.	Signal peptidase complex subunit 1.	0.994
ENSFHEP00000019690	spcs3	ENSFHEP00000019690	ENSFHEP00000003112	Signal peptidase complex subunit 2.	Signal peptidase complex subunit 3.	0.992
ENSFHEP00000020440	gcg	ENSFHEP00000020440	ENSFHEP00000020767	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.584
ENSFHEP00000020440	igf1	ENSFHEP00000020440	ENSFHEP00000002734	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin growth factor I-like protein.	0.862
ENSFHEP00000020440	pcsk1	ENSFHEP00000020440	ENSFHEP00000034923	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.739
ENSFHEP00000024666	ENSFHEP00000030023	ENSFHEP00000024666	ENSFHEP00000030023	COesterase domain-containing protein.	COesterase domain-containing protein.	0.899
ENSFHEP00000030023	ENSFHEP00000024666	ENSFHEP00000030023	ENSFHEP00000024666	COesterase domain-containing protein.	COesterase domain-containing protein.	0.899
ENSFHEP00000030023	ache	ENSFHEP00000030023	ENSFHEP00000007433	COesterase domain-containing protein.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.912
ache	ENSFHEP00000030023	ENSFHEP00000007433	ENSFHEP00000030023	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	COesterase domain-containing protein.	0.912
gcg	ENSFHEP00000020440	ENSFHEP00000020767	ENSFHEP00000020440	Glucagon b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.584
gcg	ins	ENSFHEP00000020767	ENSFHEP00000005373	Glucagon b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.584
gcg	pcsk1	ENSFHEP00000020767	ENSFHEP00000034923	Glucagon b.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.459
gcg	sec11a	ENSFHEP00000020767	ENSFHEP00000010807	Glucagon b.	Signal peptidase complex catalytic subunit SEC11.	0.615
igf1	ENSFHEP00000020440	ENSFHEP00000002734	ENSFHEP00000020440	Insulin growth factor I-like protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.862
igf1	ins	ENSFHEP00000002734	ENSFHEP00000005373	Insulin growth factor I-like protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.871
ins	gcg	ENSFHEP00000005373	ENSFHEP00000020767	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Glucagon b.	0.584
ins	igf1	ENSFHEP00000005373	ENSFHEP00000002734	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin growth factor I-like protein.	0.871
ins	pcsk1	ENSFHEP00000005373	ENSFHEP00000034923	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.739
pcsk1	ENSFHEP00000020440	ENSFHEP00000034923	ENSFHEP00000020440	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.739