(43 nodes) Regulation of TP53 Expression and Degradation network (Fundulus heteroclitus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (334 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (407 aa)
	LOC105934647	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (352 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1227 aa)
	LOC105930061	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	SGK1	Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (439 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	chek2	Checkpoint kinase 2. (458 aa)
	LOC105921936	Serine/threonine-protein phosphatase. (309 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (297 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
	ENSFHEP00000011508	Uncharacterized protein. (97 aa)
	LOC105915319	Ring finger protein 34b. (405 aa)
	txndc11	Thioredoxin domain-containing protein 11. (853 aa)
	ENSFHEP00000015671	CRIM domain-containing protein. (137 aa)
	LOC105920955	Serine/threonine-protein phosphatase. (309 aa)
	LOC105916443	Uncharacterized protein. (490 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC105927955	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	ENSFHEP00000018793	Uncharacterized protein. (82 aa)
	usp2	Ubiquitin carboxyl-terminal hydrolase. (606 aa)
	mdm4	MDM4 regulator of p53. (511 aa)
	LOC105929577	Uncharacterized protein. (787 aa)
	ENSFHEP00000020833	Uncharacterized protein. (136 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (563 aa)
	LOC105940337	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
	LOC105928804	Ring finger protein 34a. (380 aa)
	LOC105931232	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC105936652	PR domain containing 1a, with ZNF domain. (837 aa)
	mdm2	MDM2 proto-oncogene. (559 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1659 aa)
	daxx	Death-domain associated protein. (737 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (300 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSFHEP00000031550	MAPK associated protein 1. (441 aa)
	LOC105922510	PHD finger protein 20, a. (1001 aa)
	LOC105917391	PR domain containing 1b, with ZNF domain. (623 aa)
	LOC105929038	Ubiquitin carboxyl-terminal hydrolase. (400 aa)
	ENSFHEP00000034851	TAN domain-containing protein. (173 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000011508	LOC105927955	ENSFHEP00000011508	ENSFHEP00000018158	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.600
ENSFHEP00000011508	LOC105931232	ENSFHEP00000011508	ENSFHEP00000022260	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.600
ENSFHEP00000011508	LOC105934647	ENSFHEP00000011508	ENSFHEP00000001063	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.809
ENSFHEP00000011508	LOC105940337	ENSFHEP00000011508	ENSFHEP00000021435	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.600
ENSFHEP00000011508	akt1	ENSFHEP00000011508	ENSFHEP00000025994	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.600
ENSFHEP00000015671	ENSFHEP00000031550	ENSFHEP00000015671	ENSFHEP00000031550	CRIM domain-containing protein.	MAPK associated protein 1.	0.550
ENSFHEP00000015671	LOC105916443	ENSFHEP00000015671	ENSFHEP00000017854	CRIM domain-containing protein.	Uncharacterized protein.	0.858
ENSFHEP00000015671	LOC105927955	ENSFHEP00000015671	ENSFHEP00000018158	CRIM domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.753
ENSFHEP00000015671	LOC105931232	ENSFHEP00000015671	ENSFHEP00000022260	CRIM domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.753
ENSFHEP00000015671	LOC105940337	ENSFHEP00000015671	ENSFHEP00000021435	CRIM domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.753
ENSFHEP00000015671	SGK1	ENSFHEP00000015671	ENSFHEP00000005880	CRIM domain-containing protein.	Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.803
ENSFHEP00000015671	akt1	ENSFHEP00000015671	ENSFHEP00000025994	CRIM domain-containing protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.753
ENSFHEP00000015671	mlst8	ENSFHEP00000015671	ENSFHEP00000014128	CRIM domain-containing protein.	MTOR associated protein, LST8 homolog (S. cerevisiae).	0.992
ENSFHEP00000015671	mtor	ENSFHEP00000015671	ENSFHEP00000010587	CRIM domain-containing protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.992
ENSFHEP00000015671	pdpk1	ENSFHEP00000015671	ENSFHEP00000021118	CRIM domain-containing protein.	3-phosphoinositide dependent protein kinase 1b.	0.400
ENSFHEP00000015671	rictor	ENSFHEP00000015671	ENSFHEP00000027330	CRIM domain-containing protein.	RPTOR independent companion of MTOR, complex 2 a.	0.997
ENSFHEP00000018793	LOC105934647	ENSFHEP00000018793	ENSFHEP00000001063	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.436
ENSFHEP00000020833	ENSFHEP00000034851	ENSFHEP00000020833	ENSFHEP00000034851	Uncharacterized protein.	TAN domain-containing protein.	0.923
ENSFHEP00000020833	LOC105927955	ENSFHEP00000020833	ENSFHEP00000018158	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.422
ENSFHEP00000020833	LOC105931232	ENSFHEP00000020833	ENSFHEP00000022260	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.422