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bmt2 bmt2 impact impact LOC105929477 LOC105929477 LOC105936921 LOC105936921 wdr24 wdr24 nprl3 nprl3 atp6v1e1 atp6v1e1 lamtor2 lamtor2 rptor rptor LOC105931838 LOC105931838 LOC105932227 LOC105932227 CASTOR1 CASTOR1 dmrta2 dmrta2 gcn1 gcn1 lamtor5 lamtor5 LOC105939711 LOC105939711 LOC105926136 LOC105926136 depdc5 depdc5 ENSFHEP00000005917 ENSFHEP00000005917 LOC105927128 LOC105927128 LOC105939599 LOC105939599 ENSFHEP00000007615 ENSFHEP00000007615 cunh12orf66 cunh12orf66 mios mios sh3bp4 sh3bp4 ENSFHEP00000010391 ENSFHEP00000010391 mtor mtor LOC105917024 LOC105917024 LOC105922498 LOC105922498 LOC105930439 LOC105930439 txndc11 txndc11 macc1 macc1 ATP6V1B2 ATP6V1B2 mlst8 mlst8 lamtor3 lamtor3 atp6v1h atp6v1h sec13 sec13 ddit3 ddit3 atp6v1a atp6v1a rragc rragc seh1l seh1l tcirg1 tcirg1 ENSFHEP00000017385 ENSFHEP00000017385 ENSFHEP00000017412 ENSFHEP00000017412 nprl2 nprl2 cnst cnst LOC105939925 LOC105939925 dmrt2 dmrt2 dmrt3 dmrt3 mettl25 mettl25 CRYBB3 CRYBB3 ENSFHEP00000020396 ENSFHEP00000020396 atp6v0d1 atp6v0d1 castor2 castor2 ppp1r3a ppp1r3a sesn1 sesn1 ATP6V0C ATP6V0C slc38a9 slc38a9 LOC105927798 LOC105927798 LOC105931228 LOC105931228 lamtor1 lamtor1 itfg2 itfg2 atp6v1d atp6v1d rheb rheb kptn kptn atf4 atf4 wdr59 wdr59 LOC105925555 LOC105925555 DMRTA1 DMRTA1 LOC105915402 LOC105915402 atf3 atf3 fnip1 fnip1 EIF2AK4 EIF2AK4 ATP6V1A ATP6V1A LOC105925715 LOC105925715 LOC105929493 LOC105929493 flcn flcn atp6v0b atp6v0b ENSFHEP00000031995 ENSFHEP00000031995 atp6v1c1 atp6v1c1 ENSFHEP00000034479 ENSFHEP00000034479 ENSFHEP00000034505 ENSFHEP00000034505 LOC105936990 LOC105936990 lamtor4 lamtor4 atp6v1f atp6v1f
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
bmt2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (388 aa)
impactImpact RWD domain protein. (339 aa)
LOC105929477Si:ch211-153j24.3. (318 aa)
LOC105936921Doublesex and mab-3 related transcription factor 2b. (472 aa)
wdr24WD repeat domain 24. (706 aa)
nprl3Nitrogen permease regulator 3-like protein. (599 aa)
atp6v1e1ATPase H+ transporting V1 subunit E1b. (236 aa)
lamtor2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (165 aa)
rptorRegulatory associated protein of MTOR, complex 1. (1250 aa)
LOC105931838Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (257 aa)
LOC105932227Crystallin, gamma N1; Belongs to the beta/gamma-crystallin family. (183 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (327 aa)
dmrta2DMRT-like family A2. (450 aa)
gcn1GCN1 activator of EIF2AK4. (2578 aa)
lamtor5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (94 aa)
LOC105939711Lens intrinsic membrane protein 2.3. (173 aa)
LOC105926136V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
depdc5DEP domain containing 5. (883 aa)
ENSFHEP00000005917DM domain-containing protein. (126 aa)
LOC105927128Ras homolog, mTORC1 binding like 1. (184 aa)
LOC105939599V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (302 aa)
ENSFHEP00000007615Uncharacterized protein. (101 aa)
cunh12orf66Si:ch211-125a15.1. (450 aa)
miosMissing oocyte, meiosis regulator, homolog (Drosophila). (855 aa)
sh3bp4SH3-domain binding protein 4. (965 aa)
ENSFHEP00000010391CCAAT enhancer binding protein gamma. (147 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa)
LOC105917024SH3-domain binding protein 4a. (960 aa)
LOC105922498ATPase, H+ transporting, lysosomal, V1 subunit B, member a. (217 aa)
LOC105930439V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
txndc11Thioredoxin domain-containing protein 11. (853 aa)
macc1MET transcriptional regulator MACC1. (852 aa)
ATP6V1B2ATPase H+ transporting V1 subunit B2. (465 aa)
mlst8MTOR associated protein, LST8 homolog (S. cerevisiae). (334 aa)
lamtor3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
atp6v1hATPase H+ transporting V1 subunit H. (412 aa)
sec13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
ddit3DNA-damage-inducible transcript 3. (313 aa)
atp6v1aUncharacterized protein. (617 aa)
rragcRas-related GTP binding Ca. (262 aa)
seh1lSEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa)
tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (826 aa)
ENSFHEP00000017385Uncharacterized protein. (57 aa)
ENSFHEP00000017412Uncharacterized protein. (55 aa)
nprl2NPR2 like, GATOR1 complex subunit. (274 aa)
cnstConsortin_C domain-containing protein. (799 aa)
LOC105939925V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
dmrt2Doublesex and mab-3 related transcription factor 2a. (593 aa)
dmrt3Doublesex and mab-3 related transcription factor 3a. (532 aa)
mettl25Methyltransferase like 25. (557 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (323 aa)
ENSFHEP00000020396Uncharacterized protein. (54 aa)
atp6v0d1ATPase H+ transporting V0 subunit d1. (320 aa)
castor2Cytosolic arginine sensor for mTORC1 subunit 2. (290 aa)
ppp1r3aCBM21 domain-containing protein. (1332 aa)
sesn1Sestrin 1. (548 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (255 aa)
slc38a9Solute carrier family 38 member 9. (558 aa)
LOC105927798Ras-related GTP binding A. (315 aa)
LOC105931228V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
lamtor1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa)
itfg2Integrin alpha FG-GAP repeat containing 2. (433 aa)
atp6v1dATPase H+ transporting V1 subunit D. (248 aa)
rhebRas homolog, mTORC1 binding. (183 aa)
kptnKaptin (actin binding protein). (442 aa)
atf4Activating transcription factor 4b. (447 aa)
wdr59WD repeat domain 59. (941 aa)
LOC105925555Sestrin 2. (558 aa)
DMRTA1Doublesex-and mab-3-related transcription factor A1. (421 aa)
LOC105915402Activating transcription factor 4a. (442 aa)
atf3Activating transcription factor 3. (213 aa)
fnip1Folliculin interacting protein 1. (1223 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1654 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (617 aa)
LOC105925715Si:zfos-80g12.1. (371 aa)
LOC105929493CBM21 domain-containing protein. (1236 aa)
flcnFolliculin. (564 aa)
atp6v0bV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (211 aa)
ENSFHEP00000031995Uncharacterized protein. (83 aa)
atp6v1c1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (383 aa)
ENSFHEP00000034479Uncharacterized protein. (67 aa)
ENSFHEP00000034505Tankyrase_bdg_C domain-containing protein. (354 aa)
LOC105936990Consortin, connexin sorting protein b. (382 aa)
lamtor4Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (162 aa)
atp6v1fV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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