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bmt2 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (388 aa) | ||||
impact | Impact RWD domain protein. (339 aa) | ||||
LOC105929477 | Si:ch211-153j24.3. (318 aa) | ||||
LOC105936921 | Doublesex and mab-3 related transcription factor 2b. (472 aa) | ||||
wdr24 | WD repeat domain 24. (706 aa) | ||||
nprl3 | Nitrogen permease regulator 3-like protein. (599 aa) | ||||
atp6v1e1 | ATPase H+ transporting V1 subunit E1b. (236 aa) | ||||
lamtor2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (165 aa) | ||||
rptor | Regulatory associated protein of MTOR, complex 1. (1250 aa) | ||||
LOC105931838 | Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (257 aa) | ||||
LOC105932227 | Crystallin, gamma N1; Belongs to the beta/gamma-crystallin family. (183 aa) | ||||
CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1. (327 aa) | ||||
dmrta2 | DMRT-like family A2. (450 aa) | ||||
gcn1 | GCN1 activator of EIF2AK4. (2578 aa) | ||||
lamtor5 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (94 aa) | ||||
LOC105939711 | Lens intrinsic membrane protein 2.3. (173 aa) | ||||
LOC105926136 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) | ||||
depdc5 | DEP domain containing 5. (883 aa) | ||||
ENSFHEP00000005917 | DM domain-containing protein. (126 aa) | ||||
LOC105927128 | Ras homolog, mTORC1 binding like 1. (184 aa) | ||||
LOC105939599 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (302 aa) | ||||
ENSFHEP00000007615 | Uncharacterized protein. (101 aa) | ||||
cunh12orf66 | Si:ch211-125a15.1. (450 aa) | ||||
mios | Missing oocyte, meiosis regulator, homolog (Drosophila). (855 aa) | ||||
sh3bp4 | SH3-domain binding protein 4. (965 aa) | ||||
ENSFHEP00000010391 | CCAAT enhancer binding protein gamma. (147 aa) | ||||
mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2495 aa) | ||||
LOC105917024 | SH3-domain binding protein 4a. (960 aa) | ||||
LOC105922498 | ATPase, H+ transporting, lysosomal, V1 subunit B, member a. (217 aa) | ||||
LOC105930439 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa) | ||||
txndc11 | Thioredoxin domain-containing protein 11. (853 aa) | ||||
macc1 | MET transcriptional regulator MACC1. (852 aa) | ||||
ATP6V1B2 | ATPase H+ transporting V1 subunit B2. (465 aa) | ||||
mlst8 | MTOR associated protein, LST8 homolog (S. cerevisiae). (334 aa) | ||||
lamtor3 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa) | ||||
atp6v1h | ATPase H+ transporting V1 subunit H. (412 aa) | ||||
sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) | ||||
ddit3 | DNA-damage-inducible transcript 3. (313 aa) | ||||
atp6v1a | Uncharacterized protein. (617 aa) | ||||
rragc | Ras-related GTP binding Ca. (262 aa) | ||||
seh1l | SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (383 aa) | ||||
tcirg1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (826 aa) | ||||
ENSFHEP00000017385 | Uncharacterized protein. (57 aa) | ||||
ENSFHEP00000017412 | Uncharacterized protein. (55 aa) | ||||
nprl2 | NPR2 like, GATOR1 complex subunit. (274 aa) | ||||
cnst | Consortin_C domain-containing protein. (799 aa) | ||||
LOC105939925 | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa) | ||||
dmrt2 | Doublesex and mab-3 related transcription factor 2a. (593 aa) | ||||
dmrt3 | Doublesex and mab-3 related transcription factor 3a. (532 aa) | ||||
mettl25 | Methyltransferase like 25. (557 aa) | ||||
CRYBB3 | Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (323 aa) | ||||
ENSFHEP00000020396 | Uncharacterized protein. (54 aa) | ||||
atp6v0d1 | ATPase H+ transporting V0 subunit d1. (320 aa) | ||||
castor2 | Cytosolic arginine sensor for mTORC1 subunit 2. (290 aa) | ||||
ppp1r3a | CBM21 domain-containing protein. (1332 aa) | ||||
sesn1 | Sestrin 1. (548 aa) | ||||
ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (255 aa) | ||||
slc38a9 | Solute carrier family 38 member 9. (558 aa) | ||||
LOC105927798 | Ras-related GTP binding A. (315 aa) | ||||
LOC105931228 | V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) | ||||
lamtor1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (160 aa) | ||||
itfg2 | Integrin alpha FG-GAP repeat containing 2. (433 aa) | ||||
atp6v1d | ATPase H+ transporting V1 subunit D. (248 aa) | ||||
rheb | Ras homolog, mTORC1 binding. (183 aa) | ||||
kptn | Kaptin (actin binding protein). (442 aa) | ||||
atf4 | Activating transcription factor 4b. (447 aa) | ||||
wdr59 | WD repeat domain 59. (941 aa) | ||||
LOC105925555 | Sestrin 2. (558 aa) | ||||
DMRTA1 | Doublesex-and mab-3-related transcription factor A1. (421 aa) | ||||
LOC105915402 | Activating transcription factor 4a. (442 aa) | ||||
atf3 | Activating transcription factor 3. (213 aa) | ||||
fnip1 | Folliculin interacting protein 1. (1223 aa) | ||||
EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1654 aa) | ||||
ATP6V1A | V-type proton ATPase catalytic subunit A. (617 aa) | ||||
LOC105925715 | Si:zfos-80g12.1. (371 aa) | ||||
LOC105929493 | CBM21 domain-containing protein. (1236 aa) | ||||
flcn | Folliculin. (564 aa) | ||||
atp6v0b | V-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (211 aa) | ||||
ENSFHEP00000031995 | Uncharacterized protein. (83 aa) | ||||
atp6v1c1 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (383 aa) | ||||
ENSFHEP00000034479 | Uncharacterized protein. (67 aa) | ||||
ENSFHEP00000034505 | Tankyrase_bdg_C domain-containing protein. (354 aa) | ||||
LOC105936990 | Consortin, connexin sorting protein b. (382 aa) | ||||
lamtor4 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (162 aa) | ||||
atp6v1f | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |