(9 nodes) Biotin-requiring enzyme network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	pcca	Propionyl-CoA carboxylase subunit alpha. (711 aa)
	LOC105927771	Acetyl-CoA carboxylase alpha. (2337 aa)
	dbt	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (404 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (590 aa)
	acacb	Acetyl-CoA carboxylase beta. (2298 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa)
	pdhx	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (446 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (698 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLST	LOC105927771	ENSFHEP00000021556	ENSFHEP00000002430	Dihydrolipoamide S-succinyltransferase.	Acetyl-CoA carboxylase alpha.	0.562
DLST	acacb	ENSFHEP00000021556	ENSFHEP00000028758	Dihydrolipoamide S-succinyltransferase.	Acetyl-CoA carboxylase beta.	0.562
DLST	dbt	ENSFHEP00000021556	ENSFHEP00000034691	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.750
DLST	dlat	ENSFHEP00000021556	ENSFHEP00000030941	Dihydrolipoamide S-succinyltransferase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.950
DLST	mccc1	ENSFHEP00000021556	ENSFHEP00000002486	Dihydrolipoamide S-succinyltransferase.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.676
DLST	pc	ENSFHEP00000021556	ENSFHEP00000027060	Dihydrolipoamide S-succinyltransferase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.787
DLST	pcca	ENSFHEP00000021556	ENSFHEP00000010428	Dihydrolipoamide S-succinyltransferase.	Propionyl-CoA carboxylase subunit alpha.	0.676
DLST	pdhx	ENSFHEP00000021556	ENSFHEP00000026771	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.951
LOC105927771	DLST	ENSFHEP00000002430	ENSFHEP00000021556	Acetyl-CoA carboxylase alpha.	Dihydrolipoamide S-succinyltransferase.	0.562
LOC105927771	acacb	ENSFHEP00000002430	ENSFHEP00000028758	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.953
LOC105927771	dbt	ENSFHEP00000002430	ENSFHEP00000034691	Acetyl-CoA carboxylase alpha.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.562
LOC105927771	dlat	ENSFHEP00000002430	ENSFHEP00000030941	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.962
LOC105927771	mccc1	ENSFHEP00000002430	ENSFHEP00000002486	Acetyl-CoA carboxylase alpha.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.839
LOC105927771	pc	ENSFHEP00000002430	ENSFHEP00000027060	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.885
LOC105927771	pcca	ENSFHEP00000002430	ENSFHEP00000010428	Acetyl-CoA carboxylase alpha.	Propionyl-CoA carboxylase subunit alpha.	0.839
LOC105927771	pdhx	ENSFHEP00000002430	ENSFHEP00000026771	Acetyl-CoA carboxylase alpha.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.741
acacb	DLST	ENSFHEP00000028758	ENSFHEP00000021556	Acetyl-CoA carboxylase beta.	Dihydrolipoamide S-succinyltransferase.	0.562
acacb	LOC105927771	ENSFHEP00000028758	ENSFHEP00000002430	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.953
acacb	dbt	ENSFHEP00000028758	ENSFHEP00000034691	Acetyl-CoA carboxylase beta.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.562
acacb	dlat	ENSFHEP00000028758	ENSFHEP00000030941	Acetyl-CoA carboxylase beta.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.958