(45 nodes) PMP-22/EMP/MP20/Claudin family network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSFHEP00000033709	Uncharacterized protein. (147 aa)
	LOC105933626	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	LOC105915686	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	ENSFHEP00000033636	Uncharacterized protein. (181 aa)
	perp	P53 apoptosis effector PMP-22-like protein. (184 aa)
	LOC105935377	Claudin 11a. (219 aa)
	LOC105933685	Si:dkey-264d12.4. (165 aa)
	LOC105933166	Lens fiber membrane intrinsic protein. (174 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (229 aa)
	ENSFHEP00000029513	Uncharacterized protein. (197 aa)
	LOC105935446	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	LOC105935477	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
	LOC105932083	Peripheral myelin protein 22a. (175 aa)
	LOC105936686	Epithelial membrane protein 1. (160 aa)
	LOC105916654	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
	LOC105927636	Si:dkey-221l4.11. (242 aa)
	EMP1	Epithelial membrane protein 2. (158 aa)
	LOC105932684	Claudin i. (207 aa)
	LOC105924040	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
	ENSFHEP00000023684	Uncharacterized protein. (195 aa)
	CLDN3	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (162 aa)
	ENSFHEP00000023608	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (120 aa)
	LOC105917866	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (201 aa)
	LOC105929336	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
	LOC105934091	Calcium channel, voltage-dependent, gamma subunit 6a. (287 aa)
	ENSFHEP00000020413	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (132 aa)
	ENSFHEP00000019001	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (183 aa)
	LOC105916806	Uncharacterized protein. (706 aa)
	LOC105924639	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	cldn12	Claudin 12. (371 aa)
	LOC105917459	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (223 aa)
	cldn15	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	LOC105931461	Uncharacterized protein. (316 aa)
	LOC105933776	Epithelial membrane protein 3b. (165 aa)
	LOC105935476	Si:busm1-52i16.2. (333 aa)
	ENSFHEP00000011388	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (269 aa)
	LOC105925330	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	LOC105930963	Claudin 23a. (286 aa)
	CLDN14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (189 aa)
	ENSFHEP00000006316	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
	ENSFHEP00000006282	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (252 aa)
	CLDN4	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ENSFHEP00000003779	Zgc:136892. (316 aa)
	emp2	Epithelial membrane protein 2. (141 aa)
	ENSFHEP00000000928	Si:ch211-232m10.6. (295 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNG1	LOC105934091	ENSFHEP00000030998	ENSFHEP00000021764	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.	Calcium channel, voltage-dependent, gamma subunit 6a.	0.474
CLDN14	CLDN3	ENSFHEP00000008405	ENSFHEP00000023677	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
CLDN14	CLDN4	ENSFHEP00000008405	ENSFHEP00000003908	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.639
CLDN14	ENSFHEP00000003779	ENSFHEP00000008405	ENSFHEP00000003779	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Zgc:136892.	0.908
CLDN14	ENSFHEP00000006282	ENSFHEP00000008405	ENSFHEP00000006282	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.912
CLDN14	ENSFHEP00000006316	ENSFHEP00000008405	ENSFHEP00000006316	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.900
CLDN14	ENSFHEP00000019001	ENSFHEP00000008405	ENSFHEP00000019001	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.904
CLDN14	ENSFHEP00000023608	ENSFHEP00000008405	ENSFHEP00000023608	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.606
CLDN14	ENSFHEP00000023684	ENSFHEP00000008405	ENSFHEP00000023684	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.639
CLDN14	ENSFHEP00000033636	ENSFHEP00000008405	ENSFHEP00000033636	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.925
CLDN14	ENSFHEP00000033709	ENSFHEP00000008405	ENSFHEP00000033709	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.647
CLDN14	LOC105915686	ENSFHEP00000008405	ENSFHEP00000033713	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.907
CLDN14	LOC105916654	ENSFHEP00000008405	ENSFHEP00000024982	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.906
CLDN14	LOC105917459	ENSFHEP00000008405	ENSFHEP00000016345	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.943
CLDN14	LOC105924639	ENSFHEP00000008405	ENSFHEP00000017098	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.639
CLDN14	LOC105932684	ENSFHEP00000008405	ENSFHEP00000024119	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin i.	0.896
CLDN14	LOC105935377	ENSFHEP00000008405	ENSFHEP00000032209	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin 11a.	0.925
CLDN3	CLDN14	ENSFHEP00000023677	ENSFHEP00000008405	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
CLDN3	CLDN4	ENSFHEP00000023677	ENSFHEP00000003908	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.507
CLDN3	ENSFHEP00000003779	ENSFHEP00000023677	ENSFHEP00000003779	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Zgc:136892.	0.731