(30 nodes) (2022) Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. network (Fundulus heteroclitus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	LOC105933186	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC105933185	Histone H3; Belongs to the histone H3 family. (137 aa)
	ESRRB	Estrogen-related receptor beta. (480 aa)
	rpl7	Ribosomal protein L7. (174 aa)
	bdnf	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (303 aa)
	pax6	Paired box 6b. (417 aa)
	LOC105917931	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	ENSFHEP00000022956	SRY-box transcription factor 2. (306 aa)
	LOC105917193	Uncharacterized protein. (816 aa)
	LOC105922608	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1080 aa)
	ENSFHEP00000028662	Histone H3; Belongs to the histone H3 family. (97 aa)
	ENSFHEP00000028777	Histone H3; Belongs to the histone H3 family. (122 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (300 aa)
	dsp	Desmoplakin a. (2264 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (905 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (254 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	LOC105929935	JunB proto-oncogene, AP-1 transcription factor subunit b. (329 aa)
	ENSFHEP00000009414	Histone H3; Belongs to the histone H3 family. (120 aa)
	LOC105932118	POU domain protein. (496 aa)
	ENSFHEP00000005886	Histone H3; Belongs to the histone H3 family. (90 aa)
	PKP1	Plakophilin-1. (698 aa)
	LOC105930101	Histone H3; Belongs to the histone H3 family. (136 aa)
	klf4	Kruppel-like factor 4. (445 aa)
	hes1	Hairy-related 6. (279 aa)
	zeb1	Zinc finger E-box binding homeobox 1b. (1071 aa)
	egf	Epidermal growth factor. (999 aa)
	LOC105929247	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	foxa2	Forkhead box A2. (426 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000022956	LOC105932118	ENSFHEP00000022956	ENSFHEP00000009716	SRY-box transcription factor 2.	POU domain protein.	0.878
ENSFHEP00000022956	klf4	ENSFHEP00000022956	ENSFHEP00000003197	SRY-box transcription factor 2.	Kruppel-like factor 4.	0.757
ENSFHEP00000022956	pax6	ENSFHEP00000022956	ENSFHEP00000018522	SRY-box transcription factor 2.	Paired box 6b.	0.612
ESRRB	LOC105932118	ENSFHEP00000016068	ENSFHEP00000009716	Estrogen-related receptor beta.	POU domain protein.	0.669
ESRRB	klf4	ENSFHEP00000016068	ENSFHEP00000003197	Estrogen-related receptor beta.	Kruppel-like factor 4.	0.500
LOC105922608	PKP1	ENSFHEP00000027292	ENSFHEP00000004910	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-1.	0.811
LOC105922608	dsp	ENSFHEP00000027292	ENSFHEP00000030247	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoplakin a.	0.661
LOC105929935	cdk1	ENSFHEP00000008727	ENSFHEP00000028823	JunB proto-oncogene, AP-1 transcription factor subunit b.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.528
LOC105932118	ENSFHEP00000022956	ENSFHEP00000009716	ENSFHEP00000022956	POU domain protein.	SRY-box transcription factor 2.	0.878
LOC105932118	ESRRB	ENSFHEP00000009716	ENSFHEP00000016068	POU domain protein.	Estrogen-related receptor beta.	0.669
LOC105932118	egf	ENSFHEP00000009716	ENSFHEP00000006835	POU domain protein.	Epidermal growth factor.	0.436
LOC105932118	foxa2	ENSFHEP00000009716	ENSFHEP00000007056	POU domain protein.	Forkhead box A2.	0.500
LOC105932118	klf4	ENSFHEP00000009716	ENSFHEP00000003197	POU domain protein.	Kruppel-like factor 4.	0.524
PKP1	LOC105922608	ENSFHEP00000004910	ENSFHEP00000027292	Plakophilin-1.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.811
PKP1	dsp	ENSFHEP00000004910	ENSFHEP00000030247	Plakophilin-1.	Desmoplakin a.	0.673
bdnf	egf	ENSFHEP00000017236	ENSFHEP00000006835	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Epidermal growth factor.	0.544
bdnf	fgf2	ENSFHEP00000017236	ENSFHEP00000031514	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.583
bdnf	gdnf	ENSFHEP00000017236	ENSFHEP00000033333	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake.	0.637
cdk1	LOC105929935	ENSFHEP00000028823	ENSFHEP00000008727	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	JunB proto-oncogene, AP-1 transcription factor subunit b.	0.528
dsp	LOC105922608	ENSFHEP00000030247	ENSFHEP00000027292	Desmoplakin a.	Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.661