(46 nodes) Glycosaminoglycan degradation network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	get4	Guided entry of tail-anchored proteins factor 4. (323 aa)
	ENSFHEP00000031353	Uncharacterized protein. (1078 aa)
	sulf1	Sulfatase 1. (1146 aa)
	galns	Galactosamine (N-acetyl)-6-sulfatase. (524 aa)
	ENSFHEP00000030208	Uncharacterized protein. (180 aa)
	hpse	Heparanase. (532 aa)
	LOC105920139	Arylsulfatase family, member Ia. (572 aa)
	gns	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (542 aa)
	hexb	Beta-hexosaminidase. (546 aa)
	LOC105925576	Arylsulfatase family, member J. (560 aa)
	LOC105916694	Hexosaminidase A (alpha polypeptide). (330 aa)
	naglu	N-acetylglucosaminidase, alpha. (783 aa)
	hpse2	Heparanase 2. (592 aa)
	LOC105917264	Uncharacterized protein. (859 aa)
	fam149b1	Family with sequence similarity 149 member B1. (707 aa)
	idua	Iduronidase alpha-L-. (633 aa)
	LOC105927765	Iduronate 2-sulfatase. (506 aa)
	LOC105939873	Beta-galactosidase. (651 aa)
	ENSFHEP00000018468	Stanniocalcin 2b. (308 aa)
	LOC105934786	Hyaluronidase. (470 aa)
	SPAM1-2	Hyaluronidase. (441 aa)
	LOC105934783	Hyaluronidase. (514 aa)
	SPAM1	Hyaluronidase. (429 aa)
	HYAL2	Hyaluronidase. (503 aa)
	LOC105929105	N(alpha)-acetyltransferase 80, NatH catalytic subunit. (320 aa)
	arsk	Arylsulfatase family, member K. (524 aa)
	LOC105929212	Beta-galactosidase. (601 aa)
	LOC105929202	Beta-galactosidase. (641 aa)
	LOC105924990	Uncharacterized protein. (158 aa)
	LOC105921709	Uncharacterized protein. (118 aa)
	ENSFHEP00000013063	Si:dkey-192p21.6. (328 aa)
	LOC105930939	Sulfatase domain-containing protein. (739 aa)
	ENSFHEP00000012506	Uncharacterized protein; Belongs to the glycosyl hydrolase 35 family. (599 aa)
	ARSB	Arylsulfatase B. (515 aa)
	ENSFHEP00000033272	Biorientation of chromosomes in cell division 1. (162 aa)
	ENSFHEP00000033218	Uncharacterized protein. (132 aa)
	LOC105933671	Hyaluronidase. (438 aa)
	gusb	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (639 aa)
	LOC105937176	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (639 aa)
	rabggtb	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (338 aa)
	LOC105937193	Si:dkey-174i8.1. (523 aa)
	LOC105915602	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (484 aa)
	HYAL2-2	Hyaluronidase. (471 aa)
	LOC105922455	Extracellular sulfatase. (921 aa)
	sgsh	N-sulfoglucosamine sulfohydrolase (sulfamidase). (555 aa)
	LOC105929106	Hyaluronidase. (446 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	ENSFHEP00000013063	ENSFHEP00000010879	ENSFHEP00000013063	Arylsulfatase B.	Si:dkey-192p21.6.	0.505
ARSB	ENSFHEP00000030208	ENSFHEP00000010879	ENSFHEP00000030208	Arylsulfatase B.	Uncharacterized protein.	0.505
ARSB	HYAL2	ENSFHEP00000010879	ENSFHEP00000017463	Arylsulfatase B.	Hyaluronidase.	0.946
ARSB	HYAL2-2	ENSFHEP00000010879	ENSFHEP00000032630	Arylsulfatase B.	Hyaluronidase.	0.943
ARSB	LOC105915602	ENSFHEP00000010879	ENSFHEP00000001406	Arylsulfatase B.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.445
ARSB	LOC105916694	ENSFHEP00000010879	ENSFHEP00000023700	Arylsulfatase B.	Hexosaminidase A (alpha polypeptide).	0.435
ARSB	LOC105917264	ENSFHEP00000010879	ENSFHEP00000021952	Arylsulfatase B.	Uncharacterized protein.	0.439
ARSB	LOC105922455	ENSFHEP00000010879	ENSFHEP00000032479	Arylsulfatase B.	Extracellular sulfatase.	0.431
ARSB	LOC105927765	ENSFHEP00000010879	ENSFHEP00000020050	Arylsulfatase B.	Iduronate 2-sulfatase.	0.609
ARSB	LOC105934783	ENSFHEP00000010879	ENSFHEP00000018305	Arylsulfatase B.	Hyaluronidase.	0.947
ARSB	LOC105937176	ENSFHEP00000010879	ENSFHEP00000006953	Arylsulfatase B.	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	0.443
ARSB	LOC105939873	ENSFHEP00000010879	ENSFHEP00000019537	Arylsulfatase B.	Beta-galactosidase.	0.443
ARSB	arsk	ENSFHEP00000010879	ENSFHEP00000016399	Arylsulfatase B.	Arylsulfatase family, member K.	0.710
ARSB	fam149b1	ENSFHEP00000010879	ENSFHEP00000021008	Arylsulfatase B.	Family with sequence similarity 149 member B1.	0.444
ARSB	gns	ENSFHEP00000010879	ENSFHEP00000024790	Arylsulfatase B.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.446
ARSB	gusb	ENSFHEP00000010879	ENSFHEP00000008112	Arylsulfatase B.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.677
ARSB	hexb	ENSFHEP00000010879	ENSFHEP00000024513	Arylsulfatase B.	Beta-hexosaminidase.	0.490
ARSB	idua	ENSFHEP00000010879	ENSFHEP00000020174	Arylsulfatase B.	Iduronidase alpha-L-.	0.960
ARSB	sulf1	ENSFHEP00000010879	ENSFHEP00000031641	Arylsulfatase B.	Sulfatase 1.	0.432
ENSFHEP00000012506	LOC105915602	ENSFHEP00000012506	ENSFHEP00000001406	Uncharacterized protein; Belongs to the glycosyl hydrolase 35 family.	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family.	0.403