(33 nodes) One carbon pool by folate network (Fundulus heteroclitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	qtrt2	Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (418 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (417 aa)
	mthfsd	Methenyltetrahydrofolate synthetase domain containing. (504 aa)
	shmt1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (512 aa)
	mthfd1l	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (974 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (681 aa)
	ENSFHEP00000021849	SHMT domain-containing protein. (169 aa)
	LOC105938509	Patatin like phospholipase domain containing 8. (820 aa)
	LOC105917737	Zgc:153031. (200 aa)
	ftcd	Zgc:153901. (336 aa)
	LOC105916055	SHMT domain-containing protein. (483 aa)
	qtrt1	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (417 aa)
	ENSFHEP00000030739	SHMT domain-containing protein. (88 aa)
	mthfd2	Uncharacterized protein. (338 aa)
	gart	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1014 aa)
	LOC105933714	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	LOC105937516	Patatin-like phospholipase domain containing 8. (728 aa)
	dhfr	Dihydrofolate reductase. (165 aa)
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1272 aa)
	LOC105926091	Uncharacterized protein. (282 aa)
	LOC105928409	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (363 aa)
	mthfs	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa)
	atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (628 aa)
	LOC105916057	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
	ENSFHEP00000009699	Uncharacterized protein. (209 aa)
	tyms	Thymidylate synthetase. (327 aa)
	ovca2	OVCA2 serine hydrolase domain containing. (225 aa)
	TSTD2	Thiosulfate sulfurtransferase/rhodanese domain-containing 2-like protein. (463 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b. (526 aa)
	aldh1l2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (847 aa)
	ENSFHEP00000013747	Aldedh domain-containing protein. (163 aa)
	ENSFHEP00000015728	SHMT domain-containing protein. (48 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000009699	ENSFHEP00000013747	ENSFHEP00000009699	ENSFHEP00000013747	Uncharacterized protein.	Aldedh domain-containing protein.	0.748
ENSFHEP00000009699	ENSFHEP00000015728	ENSFHEP00000009699	ENSFHEP00000015728	Uncharacterized protein.	SHMT domain-containing protein.	0.798
ENSFHEP00000009699	ENSFHEP00000021849	ENSFHEP00000009699	ENSFHEP00000021849	Uncharacterized protein.	SHMT domain-containing protein.	0.877
ENSFHEP00000009699	ENSFHEP00000030739	ENSFHEP00000009699	ENSFHEP00000030739	Uncharacterized protein.	SHMT domain-containing protein.	0.798
ENSFHEP00000009699	LOC105916055	ENSFHEP00000009699	ENSFHEP00000027456	Uncharacterized protein.	SHMT domain-containing protein.	0.798
ENSFHEP00000009699	LOC105916057	ENSFHEP00000009699	ENSFHEP00000009641	Uncharacterized protein.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.798
ENSFHEP00000009699	LOC105917737	ENSFHEP00000009699	ENSFHEP00000025955	Uncharacterized protein.	Zgc:153031.	0.828
ENSFHEP00000009699	LOC105928409	ENSFHEP00000009699	ENSFHEP00000004658	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like.	0.877
ENSFHEP00000009699	LOC105933714	ENSFHEP00000009699	ENSFHEP00000032018	Uncharacterized protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.784
ENSFHEP00000009699	aldh1l2	ENSFHEP00000009699	ENSFHEP00000013765	Uncharacterized protein.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.748
ENSFHEP00000009699	amt	ENSFHEP00000009699	ENSFHEP00000016897	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.878
ENSFHEP00000009699	atic	ENSFHEP00000009699	ENSFHEP00000008667	Uncharacterized protein.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.977
ENSFHEP00000009699	dhfr	ENSFHEP00000009699	ENSFHEP00000000250	Uncharacterized protein.	Dihydrofolate reductase.	0.838
ENSFHEP00000009699	ftcd	ENSFHEP00000009699	ENSFHEP00000026913	Uncharacterized protein.	Zgc:153901.	0.924
ENSFHEP00000009699	gart	ENSFHEP00000009699	ENSFHEP00000032372	Uncharacterized protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.998
ENSFHEP00000009699	mthfd1l	ENSFHEP00000009699	ENSFHEP00000021307	Uncharacterized protein.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.740
ENSFHEP00000009699	mthfd2	ENSFHEP00000009699	ENSFHEP00000031377	Uncharacterized protein.	Uncharacterized protein.	0.877
ENSFHEP00000009699	mthfr	ENSFHEP00000009699	ENSFHEP00000021448	Uncharacterized protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.870
ENSFHEP00000009699	mthfs	ENSFHEP00000009699	ENSFHEP00000008544	Uncharacterized protein.	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.	0.886
ENSFHEP00000009699	mthfsd	ENSFHEP00000009699	ENSFHEP00000019365	Uncharacterized protein.	Methenyltetrahydrofolate synthetase domain containing.	0.853