STRINGSTRING
brip1 brip1 ENSFHEP00000034851 ENSFHEP00000034851 LOC105932436 LOC105932436 babam1 babam1 top3b top3b top3a top3a pold1 pold1 mcfd2 mcfd2 rad52 rad52 ENSFHEP00000032334 ENSFHEP00000032334 nbn nbn rpa3 rpa3 pif1 pif1 ddx52 ddx52 meiob meiob abraxas1 abraxas1 helq helq ENSFHEP00000030190 ENSFHEP00000030190 pithd1 pithd1 pold3 pold3 ENSFHEP00000029560 ENSFHEP00000029560 CNP CNP ENSFHEP00000027913 ENSFHEP00000027913 ENSFHEP00000026960 ENSFHEP00000026960 recql4 recql4 pold2 pold2 brca1 brca1 ENSFHEP00000026441 ENSFHEP00000026441 n4bp2 n4bp2 slc4a1ap slc4a1ap MPHOSPH9 MPHOSPH9 eme1 eme1 mre11 mre11 topbp1 topbp1 rpa1 rpa1 ssbp1 ssbp1 SUGP1 SUGP1 ENSFHEP00000021488 ENSFHEP00000021488 ENSFHEP00000021362 ENSFHEP00000021362 ENSFHEP00000021011 ENSFHEP00000021011 ENSFHEP00000020833 ENSFHEP00000020833 uimc1 uimc1 LOC105922837 LOC105922837 abraxas2 abraxas2 ppil3 ppil3 rbbp8 rbbp8 LOC105924718 LOC105924718 recql5 recql5 LOC105937671 LOC105937671 sycp3 sycp3 rad51c rad51c rtel1 rtel1 dmc1 dmc1 ficd ficd stn1 stn1 rad54b rad54b LOC105925219 LOC105925219 LOC105931509 LOC105931509 unc93b1 unc93b1 RPA1 RPA1 pold4 pold4 sem1 sem1 xrcc3 xrcc3 atrx atrx brca2 brca2 n4bp2l2 n4bp2l2 rad50 rad50 XRCC2 XRCC2 LOC105917713 LOC105917713 yju2 yju2 cunh12orf66 cunh12orf66 LOC105922669 LOC105922669 sap130 sap130 rad51 rad51 mcph1 mcph1 slf1 slf1 brcc3 brcc3 rad51d rad51d unc93a unc93a ENSFHEP00000005055 ENSFHEP00000005055 palb2 palb2 ENSFHEP00000003442 ENSFHEP00000003442 mus81 mus81 PTGDR2 PTGDR2 ENSFHEP00000001801 ENSFHEP00000001801 ENSFHEP00000001303 ENSFHEP00000001303
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
brip1BRCA1 interacting protein C-terminal helicase 1. (1443 aa)
ENSFHEP00000034851TAN domain-containing protein. (173 aa)
LOC105932436Transmembrane 6 superfamily member 2. (380 aa)
babam1BRISC and BRCA1 A complex member 1. (417 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
pold1DNA polymerase. (1152 aa)
mcfd2Multiple coagulation factor deficiency 2. (198 aa)
rad52RAD52 homolog, DNA repair protein. (419 aa)
ENSFHEP00000032334Uncharacterized protein. (314 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (820 aa)
rpa3Replication protein A3. (122 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (631 aa)
ddx52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52. (655 aa)
meiobMethionine sulfoxide reductase B1b. (385 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (349 aa)
helqHelicase, POLQ like. (1022 aa)
ENSFHEP00000030190Uncharacterized protein. (81 aa)
pithd1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (213 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (290 aa)
ENSFHEP00000029560Uncharacterized protein. (74 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (645 aa)
ENSFHEP00000027913Uncharacterized protein. (101 aa)
ENSFHEP00000026960Uncharacterized protein. (271 aa)
recql4RecQ helicase-like 4. (1523 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
brca1Breast cancer 1, early onset. (1357 aa)
ENSFHEP00000026441BRISC and BRCA1 A complex member 2. (267 aa)
n4bp2NEDD4 binding protein 2. (1664 aa)
slc4a1apSolute carrier family 4 member 1 adaptor protein. (749 aa)
MPHOSPH9M-phase phosphoprotein 9. (1263 aa)
eme1Essential meiotic structure-specific endonuclease 1. (502 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (693 aa)
topbp1DNA topoisomerase II binding protein 1. (1256 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa)
ssbp1Single-stranded DNA-binding protein, mitochondrial. (147 aa)
SUGP1SURP and G-patch domain containing 1. (636 aa)
ENSFHEP00000021488Leucine rich adaptor protein 1. (165 aa)
ENSFHEP00000021362Replication protein A2. (267 aa)
ENSFHEP00000021011PRKR interacting protein 1. (135 aa)
ENSFHEP00000020833Uncharacterized protein. (136 aa)
uimc1Uncharacterized protein. (942 aa)
LOC105922837BRCT domain-containing protein. (146 aa)
abraxas2Abraxas 2, BRISC complex subunit. (455 aa)
ppil3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
rbbp8Uncharacterized protein. (663 aa)
LOC105924718Uncharacterized protein. (381 aa)
recql5RecQ helicase-like 5. (1014 aa)
LOC105937671RPA_C domain-containing protein. (247 aa)
sycp3Synaptonemal complex protein 3. (239 aa)
rad51cRAD51 paralog C. (341 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1031 aa)
dmc1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
ficdFIC domain containing. (451 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (357 aa)
rad54bRAD54 homolog B. (881 aa)
LOC105925219Uncharacterized protein. (314 aa)
LOC105931509Prostaglandin D2 receptor 2. (449 aa)
unc93b1Unc-93 homolog B1, TLR signaling regulator. (625 aa)
RPA1Uncharacterized protein. (253 aa)
pold4Uncharacterized protein. (124 aa)
sem1SEM1 26S proteasome complex subunit. (118 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (344 aa)
atrxATRX chromatin remodeler. (1852 aa)
brca2BRCA2 DNA repair associated. (2841 aa)
n4bp2l2NEDD4 binding protein 2-like 2. (492 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
XRCC2X-ray repair cross complementing 2. (235 aa)
LOC105917713Src homology 2 domain containing transforming protein D, a. (416 aa)
yju2YJU2 splicing factor homolog. (348 aa)
cunh12orf66Si:ch211-125a15.1. (450 aa)
LOC105922669RAD54 like. (592 aa)
sap130Sin3A-associated protein a. (1044 aa)
rad51RAD51 recombinase; Belongs to the RecA family. (142 aa)
mcph1Microcephalin 1. (809 aa)
slf1Ankyrin repeat domain-containing protein 16. (887 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (239 aa)
rad51dRAD51 paralog D. (334 aa)
unc93aUnc-93 homolog A. (463 aa)
ENSFHEP00000005055Reverse transcriptase domain-containing protein. (385 aa)
palb2PALB2_WD40 domain-containing protein. (1269 aa)
ENSFHEP00000003442Uncharacterized protein. (127 aa)
mus81MUS81 structure-specific endonuclease subunit. (612 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
ENSFHEP00000001801Bloom syndrome, RecQ helicase. (1405 aa)
ENSFHEP00000001303Uncharacterized protein. (1401 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.