(18 nodes) Non-homologous end-joining network (Fundulus heteroclitus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (566 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	lrmda	Leucine rich melanocyte differentiation associated. (233 aa)
	LOC105925236	Flap endonuclease 1. (348 aa)
	gtf3c3	General transcription factor IIIC, polypeptide 3. (982 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3917 aa)
	LOC105915523	X-ray repair complementing defective repair in Chinese hamster cells 4. (278 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (693 aa)
	ENSFHEP00000025154	Uncharacterized protein. (230 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
	enkd1	Enkurin domain containing 1. (341 aa)
	polm	Polymerase (DNA directed), mu. (620 aa)
	ENSFHEP00000029061	Uncharacterized protein. (208 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	dntt	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (499 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (567 aa)
	lig4	DNA ligase. (1006 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (368 aa)

Your Current Organism:

Fundulus heteroclitus

NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSFHEP00000025154	ENSFHEP00000029061	ENSFHEP00000025154	ENSFHEP00000029061	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSFHEP00000025154	LOC105915523	ENSFHEP00000025154	ENSFHEP00000022816	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.952
ENSFHEP00000025154	LOC105925236	ENSFHEP00000025154	ENSFHEP00000015690	Uncharacterized protein.	Flap endonuclease 1.	0.416
ENSFHEP00000025154	dclre1c	ENSFHEP00000025154	ENSFHEP00000008153	Uncharacterized protein.	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae).	0.401
ENSFHEP00000025154	dntt	ENSFHEP00000025154	ENSFHEP00000033732	Uncharacterized protein.	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	0.408
ENSFHEP00000025154	enkd1	ENSFHEP00000025154	ENSFHEP00000026191	Uncharacterized protein.	Enkurin domain containing 1.	0.408
ENSFHEP00000025154	fen1	ENSFHEP00000025154	ENSFHEP00000008030	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.416
ENSFHEP00000025154	lig4	ENSFHEP00000025154	ENSFHEP00000006360	Uncharacterized protein.	DNA ligase.	0.995
ENSFHEP00000025154	poll	ENSFHEP00000025154	ENSFHEP00000035164	Uncharacterized protein.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.408
ENSFHEP00000025154	polm	ENSFHEP00000025154	ENSFHEP00000027269	Uncharacterized protein.	Polymerase (DNA directed), mu.	0.408
ENSFHEP00000025154	prkdc	ENSFHEP00000025154	ENSFHEP00000018937	Uncharacterized protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.742
ENSFHEP00000025154	xrcc5	ENSFHEP00000025154	ENSFHEP00000025953	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.964
ENSFHEP00000025154	xrcc6	ENSFHEP00000025154	ENSFHEP00000031142	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.979
ENSFHEP00000029061	ENSFHEP00000025154	ENSFHEP00000029061	ENSFHEP00000025154	Uncharacterized protein.	Uncharacterized protein.	0.814
ENSFHEP00000029061	LOC105915523	ENSFHEP00000029061	ENSFHEP00000022816	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.804
ENSFHEP00000029061	dclre1c	ENSFHEP00000029061	ENSFHEP00000008153	Uncharacterized protein.	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae).	0.847
ENSFHEP00000029061	dntt	ENSFHEP00000029061	ENSFHEP00000033732	Uncharacterized protein.	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	0.684
ENSFHEP00000029061	enkd1	ENSFHEP00000029061	ENSFHEP00000026191	Uncharacterized protein.	Enkurin domain containing 1.	0.581
ENSFHEP00000029061	lig4	ENSFHEP00000029061	ENSFHEP00000006360	Uncharacterized protein.	DNA ligase.	0.991
ENSFHEP00000029061	poll	ENSFHEP00000029061	ENSFHEP00000035164	Uncharacterized protein.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.775