STRINGSTRING
fan1 fan1 brip1 brip1 usp1 usp1 ENSFHEP00000001801 ENSFHEP00000001801 PTGDR2 PTGDR2 mus81 mus81 atrip atrip hes1 hes1 LOC105921368 LOC105921368 palb2 palb2 LOC105926550 LOC105926550 LOC105920752 LOC105920752 ENSFHEP00000005052 ENSFHEP00000005052 ENSFHEP00000005309 ENSFHEP00000005309 ENSFHEP00000005371 ENSFHEP00000005371 mical2 mical2 polk polk ENSFHEP00000005695 ENSFHEP00000005695 faap100 faap100 ercc1 ercc1 rad51 rad51 FANCA FANCA ENSFHEP00000008361 ENSFHEP00000008361 polq polq ENSFHEP00000009877 ENSFHEP00000009877 fancg fancg n4bp2l2 n4bp2l2 brca2 brca2 slx4 slx4 RPA1 RPA1 LOC105931509 LOC105931509 LOC105918253 LOC105918253 ENSFHEP00000013136 ENSFHEP00000013136 ercc4 ercc4 atr atr rtel1 rtel1 rad51c rad51c fancc fancc wdr48 wdr48 LOC105937671 LOC105937671 mlh1 mlh1 LOC105928579 LOC105928579 CENPS CENPS fancb fancb ENSFHEP00000020088 ENSFHEP00000020088 ENSFHEP00000020128 ENSFHEP00000020128 rmi1 rmi1 LOC105916216 LOC105916216 ENSFHEP00000021362 ENSFHEP00000021362 telo2 telo2 polh polh HES2 HES2 rpa1 rpa1 poli poli fance fance nutf2 nutf2 fancd2 fancd2 eme1 eme1 n4bp2 n4bp2 cenpx cenpx LOC105916117 LOC105916117 fanci fanci brca1 brca1 rev3l rev3l fancf fancf CNP CNP rev1 rev1 faap24 faap24 pithd1 pithd1 ENSFHEP00000030190 ENSFHEP00000030190 LOC105925220 LOC105925220 rpa3 rpa3 pms2 pms2 rmi2 rmi2 top3a top3a top3b top3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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fan1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (967 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1443 aa)
usp1Ubiquitin carboxyl-terminal hydrolase. (798 aa)
ENSFHEP00000001801Bloom syndrome, RecQ helicase. (1405 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
mus81MUS81 structure-specific endonuclease subunit. (612 aa)
atripUncharacterized protein. (774 aa)
hes1Hairy-related 6. (279 aa)
LOC105921368RING-type domain-containing protein. (233 aa)
palb2PALB2_WD40 domain-containing protein. (1269 aa)
LOC105926550Microtubule associated monooxygenase, calponin and LIM domain containing 3a. (2170 aa)
LOC105920752Ubiquitin-conjugating enzyme E2T (putative). (194 aa)
ENSFHEP00000005052Terminal nucleotidyltransferase 2. (366 aa)
ENSFHEP00000005309Uncharacterized protein. (363 aa)
ENSFHEP00000005371Uncharacterized protein. (597 aa)
mical2Microtubule associated monooxygenase, calponin and LIM domain containing 2a. (1021 aa)
polkPolymerase (DNA directed) kappa. (509 aa)
ENSFHEP00000005695Orange domain-containing protein. (187 aa)
faap100Si:dkey-57h18.1. (848 aa)
ercc1Excision repair cross-complementation group 1. (366 aa)
rad51RAD51 recombinase; Belongs to the RecA family. (142 aa)
FANCAFA complementation group A. (990 aa)
ENSFHEP00000008361FAD_binding_3 domain-containing protein. (287 aa)
polqPolymerase (DNA directed), theta. (2666 aa)
ENSFHEP00000009877POLAc domain-containing protein. (594 aa)
fancgFA complementation group G. (621 aa)
n4bp2l2NEDD4 binding protein 2-like 2. (492 aa)
brca2BRCA2 DNA repair associated. (2841 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1496 aa)
RPA1Uncharacterized protein. (253 aa)
LOC105931509Prostaglandin D2 receptor 2. (449 aa)
LOC105918253Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1256 aa)
ENSFHEP00000013136WD-3 domain-containing protein. (283 aa)
ercc4Excision repair cross-complementation group 4. (897 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2414 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1031 aa)
rad51cRAD51 paralog C. (341 aa)
fanccFA complementation group C. (633 aa)
wdr48WD repeat domain 48b. (700 aa)
LOC105937671RPA_C domain-containing protein. (247 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (715 aa)
LOC105928579NTF2 domain-containing protein. (130 aa)
CENPSCentromere protein S. (115 aa)
fancbFA complementation group B. (848 aa)
ENSFHEP00000020088FAD_binding_3 domain-containing protein. (309 aa)
ENSFHEP00000020128Calponin-homology (CH) domain-containing protein. (121 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (687 aa)
LOC105916216Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (262 aa)
ENSFHEP00000021362Replication protein A2. (267 aa)
telo2TEL2, telomere maintenance 2, homolog (S. cerevisiae). (740 aa)
polhPolymerase (DNA directed), eta. (721 aa)
HES2Hes family bHLH transcription factor 2, tandem duplicate 1. (140 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (604 aa)
poliPolymerase (DNA directed) iota. (698 aa)
fanceFA complementation group E. (562 aa)
nutf2Nuclear transport factor 2. (127 aa)
fancd2FA complementation group D2. (1376 aa)
eme1Essential meiotic structure-specific endonuclease 1. (502 aa)
n4bp2NEDD4 binding protein 2. (1664 aa)
cenpxCentromere protein X. (95 aa)
LOC105916117Hairy-related 9. (296 aa)
fanciFA complementation group I. (1308 aa)
brca1Breast cancer 1, early onset. (1357 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (3019 aa)
fancfFA complementation group F. (362 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (645 aa)
rev1REV1 DNA directed polymerase. (1353 aa)
faap24FA core complex associated protein 24. (214 aa)
pithd1PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1. (213 aa)
ENSFHEP00000030190Uncharacterized protein. (81 aa)
LOC105925220Uncharacterized protein. (243 aa)
rpa3Replication protein A3. (122 aa)
pms2PMS1 homolog 2, mismatch repair system component. (848 aa)
rmi2RecQ mediated genome instability 2. (132 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
Your Current Organism:
Fundulus heteroclitus
NCBI taxonomy Id: 8078
Other names: Atlantic killifish, F. heteroclitus, killifish, mummichog
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